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A kind of hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide compound salt and its preparation method and application

A technology of hydroxypropyltrimethylammonium chloride and carboxypolysaccharide, which is applied in cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve the problems of poor moisture absorption and moisturizing activity, and achieve low material cost, wide application prospects, and wide application Effect

Active Publication Date: 2019-07-23
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan has some hygroscopic and moisturizing activity, but its hygroscopic and moisturizing activity is poor compared with hyaluronic acid, which is not enough to be developed as a hygroscopic humectant substitute

Method used

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  • A kind of hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide compound salt and its preparation method and application
  • A kind of hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide compound salt and its preparation method and application
  • A kind of hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide compound salt and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In this example, the target compound hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide complex salt was synthesized according to the above synthetic route.

[0041]1) Preparation of hydroxypropyltrimethylammonium chloride chitosan: Weigh 4.83 g chitosan and disperse it in 20mL isopropanol to swell at room temperature, add 2,3-epoxypropyltrimethylammonium chloride 13.59 g, reacted at 55-65°C for 9 hours; then added 60mL of methanol for alcohol precipitation, the resulting precipitate was washed with 85% ethanol and suction filtered to obtain a filter cake, and dried to constant weight to obtain hydroxypropyltrimethyl chloride ammonium chitosan;

[0042] 2) Preparation of hydroxypropyltrimethylammonium chloride chitosan-carboxymethyl chitosan sodium salt: Dissolve 3.42 g of hydroxypropyltrimethylammonium chloride chitosan obtained above in 20 mL deionized water, Then take by weighing 3.72 g carboxymethyl chitosan sodium and be dissolved in 74mL deion...

Embodiment 2

[0044] The difference from Example 1 is:

[0045] 1) Preparation of hydroxypropyltrimethylammonium chloride chitosan: Weigh 4.83 g chitosan and disperse it in 30mL isopropanol to swell at room temperature, add 2,3-epoxypropyltrimethylammonium chloride 19.32 g, reacted at 55-65°C for 12 hours; then added 70mL of methanol for alcohol precipitation, the resulting precipitate was washed with 85% ethanol and suction filtered to obtain a filter cake, and dried to constant weight to obtain hydroxypropyltrimethyl chloride ammonium chitosan;

[0046] 2) Preparation of hydroxypropyltrimethylammonium chloride chitosan-carboxymethyl inulin sodium salt: 3.42 g of hydroxypropyltrimethylammonium chloride chitosan obtained above was dissolved in 30 mL deionized water, and then Weigh 3.73 g of sodium carboxymethyl inulin and dissolve it in 37 mL of deionized water, then slowly add the aqueous solution of sodium carboxymethyl inulin to the former, react at room temperature for 18 hours, and th...

Embodiment 3

[0048] The difference from Example 1 is:

[0049] 1) Preparation of hydroxypropyltrimethylammonium chloride chitosan: Weigh 4.83 g chitosan and disperse it in 40mL isopropanol to swell at room temperature, add 2,3-epoxypropyltrimethylammonium chloride 24.15 g, reacted at 55-65°C for 12 hours; then added 80mL of methanol for alcohol precipitation, the resulting precipitate was washed with 85% ethanol and suction filtered to obtain a filter cake, and dried to constant weight to obtain hydroxypropyltrimethyl chloride ammonium chitosan;

[0050] 2) Preparation of hydroxypropyltrimethylammonium chloride chitosan-hyaluronic acid sodium salt: Dissolve 3.42 g of hydroxypropyltrimethylammonium chloride chitosan obtained above in 40 mL of deionized water, and then weigh 4.08 g of sodium hyaluronate was dissolved in 27 mL of deionized water, and then the sodium hyaluronate aqueous solution was slowly added dropwise to the former at room temperature to react for 24 hours, and then the mi...

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Abstract

The invention relates to the food and biomedicine industries, in particular to a hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide composite salt and a preparation method and application thereof. The hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide composite salt is shown in formula (1): the advantages of the present invention are that the reaction process is simple, the conditions are mild, the reaction materials are cheap and easy to obtain, and it is easy to promote industrial application, and Studies have shown that hydroxypropyl trimethyl ammonium chloride chitosan-carboxy polysaccharide complex salt has good water solubility and excellent moisture absorption and moisturizing activity, which can be widely used in the field of cosmetics and the pharmaceutical industry. Formula (1) in formula (1)

Description

technical field [0001] The invention relates to food and biomedicine industries, in particular to a hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide compound salt and a preparation method and application thereof. Background technique [0002] Hygroscopic humectants are a class of hygroscopic compounds that can absorb moisture from humid air, and achieve moisturizing, moisturizing and other effects by absorbing and retaining moisture. Hygroscopic moisturizers are mainly used in food and daily chemical fields. Moisturizer is an indispensable and important ingredient in cosmetics. Hyaluronic acid derived from organisms is an excellent moisturizer. It is used in high-end cosmetics to make the skin elastic and smooth, and delay skin aging. However, its raw materials are limited, the preparation process is complicated, and the cost is high, which restricts the wide application of hyaluronic acid. For this reason, people continue to research and develop the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A23L29/30A61K8/73A61K47/36A61Q19/00
Inventor 郭占勇宓英其谭文强张晶晶陈源董方李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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