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Process for preparing O-2'-hydroxypropyl trimethyl ammonium chloride chitosan

The technology of hydroxypropyltrimethylammonium chloride and glycidyltrimethylammonium chloride is applied in the field of quaternary ammonium salting of chitosan, can solve the problems of complex synthesis method and the like, achieves high reactivity, The effect of reducing the degree of degradation reaction and easy adjustment

Inactive Publication Date: 2009-01-14
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The synthesis method is very complex

Method used

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  • Process for preparing O-2'-hydroxypropyl trimethyl ammonium chloride chitosan
  • Process for preparing O-2'-hydroxypropyl trimethyl ammonium chloride chitosan
  • Process for preparing O-2'-hydroxypropyl trimethyl ammonium chloride chitosan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-9

[0030] Examples 1-9 prepared O-2'-HTACCt according to the above-mentioned step a, and prepared O-2'-HTACCts according to the above-mentioned step b. In Examples 1-9, different β-chitin particle sizes, modifiers, modifier / β-chitin molar ratios, substitution reaction temperatures, substitution reaction times, and dispersion solvents were used. The conditions for preparing O-2'-HTACCt and the degree of substitution of the product are shown in Table 1. The molar ratio in Table 1 refers to the modifier / β-chitin molar ratio. A in the modifier is 2,3-GTAC, and B is 3-Cl-2-HTAC.

[0031] Table 1 Relevant parameters of the substitution reaction

[0032] Example

Particle size μm

modifier

Dispersion solvent

temperature °C

The molar ratio of

time h

Degree of substitution%

1

5

A

Isopropanol

20

0.5∶1

12

33.30

2

10

B

Isopropanol

40

4∶1

6

71.06

3

300

A+B

...

Embodiment 9

[0054] In Example 9, O-2'-HTACCt was prepared by deacetylation, and the degree of deacetylation of the O-2'-HTACCts sample was 65.32%.

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PUM

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Abstract

The invention provides an O-2`-Hydroxypropyltrimethyl ammonium chloride chitosan preparation method, which comprises the following steps: firstly, Beta-Chitin is reacted with modifying agent to synthesize O-2`-Hydroxypropyltrimethyl ammonium chloride Chitin; secondly, acetyl of C2 digit on O-2`-HTACCt sugar ring is divested through reaction to obtain O-2`-HTACCts. Quaternary ammonium salt derivatives displacement reaction positioning in the invention occurs on hydroxyl of Beta-Chitin sugar ring, Chitin and chitosan quaternary ammonium salt derivatives of the hydroxyl positioning displacement are obtained, thus the method is simple and reliable. The degree of substitution (DS) of the intermediate product O-2`-HTACCt is more easily adjusted. The deacetylating reaction conditions are mild, the chitosan trunk chain degradation reaction degree is reduced, therefore O-2`-HTACCts with the high deacetylation degree (DD) and the high degree of substitution (DS) are obtained.

Description

【Technical field】 [0001] The invention relates to the technical field of quaternary ammonium saltation of chitosan, in particular to a simple method for quaternary ammonium saltation of chitosan by positioning and replacing it. 【Background technique】 [0002] The functional modification of biopolymer chitin / chitosan has always been the most cutting-edge and most vital research direction in chitin chemistry, especially through the chemical modification of chitin / chitosan molecular side chains to introduce other functional functional groups , to obtain new functional chitin / chitosan derivatives, which plays a very important role in enhancing the application value of chitin / chitosan. [0003] The purpose of chitosan quaternization is to chemically bond quaternary ammonium salt groups into chitosan molecules (mainly on the side chain) to obtain derivatives that can be dissolved in water at any pH value and have stronger cationic properties. Expand the function and application r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 吴奕光
Owner SHENZHEN UNIV
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