The invention discloses a dry
granulation process of fatty oil-containing
traditional Chinese medicine decoction piece extract
powder, which comprises the following steps: uniformly mixing the extract
powder of fatty oil-containing
traditional Chinese medicine decoction pieces with the total fatty
oil content of 1-200mgg <-1 > and a filler, then pressing the uniformly mixed
powder into strips by using a dry
granulation machine, and crushing and sieving, thereby obtaining the fatty oil-containing
traditional Chinese medicine decoction piece extract powder, the filling agent comprises
cyclodextrin; the technological parameters of the dry
granulation are as follows: the using amount of the filler is 10-80% of the total material
mass, the pressure of a roller is 30-200bar, and the rotating speed of the roller is 2-10rpm. According to the method, the
caking strength, the particle forming rate, the particle
friability, the particle
bulk density, the particle repose angle and the particle dissolubility of the extract powder after the filler is added are taken as evaluation indexes, the process parameters of dry granulation of the fatty oil-containing traditional Chinese
medicine decoction piece extract powder are optimized by adopting a single-factor test and an orthogonal test, the process is stable and feasible, and the obtained particles are high in
drug loading capacity and good in stability. The flowability is good, the
hardness is moderate, and a reference is provided for large-scale application of a dry granulation process of the fatty oil-containing traditional Chinese
medicine decoction piece extract powder.