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Chitosan quaternary ammonium salt, preparing method and application of the same

The technology of chitosan quaternary ammonium salt and quaternary ammonium salt is applied in the field of chitosan quaternary ammonium salt and its preparation, which can solve the problems of skin irritation, product viscosity decrease, limited application and the like, and achieves significant bacteriostatic activity, Low cost, delayed cell damage effect

Inactive Publication Date: 2008-02-27
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, chitosan can only be dissolved in dilute acid solution, making its product slightly acidic, which not only has an irritating effect on the skin, but also slowly degrades over time, reducing the viscosity of the product.
This instability of chitosan solution also limits its application in cosmetics and food industry to a certain extent.

Method used

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  • Chitosan quaternary ammonium salt, preparing method and application of the same
  • Chitosan quaternary ammonium salt, preparing method and application of the same
  • Chitosan quaternary ammonium salt, preparing method and application of the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation method of chitosan quaternary ammonium salt (HHACC) and chitosan quaternary ammonium salt (LHACC):

[0045] 1) Weigh 5g molecular weight as 5.0×10 5 The chitosan powder of D (see Figure 1) or 5 g of chitosan powder with a molecular weight of 8000D; wherein: the chitosan oligosaccharide (see Figure 2) is prepared by the microwave action method, see the microwave-degraded chitosan compound and its preparation The patent of the method, the patent number is 03138817.5.

[0046] 2) adding distilled water to the weighed chitosan, the amount of which is 10 times the weight and volume of the chitosan, and heating to 60° C. under stirring;

[0047] 3) to the solution of step 2), add the isopropanol of 4g and the glycidyl trimethyl ammonium chloride of 3 times the molar weight of chitosan powder, react after 3 hours for standby, the product is white, soluble small particles;

[0048] 4) Adjust the reaction solution in step 3) with HCl to make its pH value 5.5;

[0...

Embodiment 2

[0080] 1) Weigh 5g molecular weight as 5.0×10 5 D chitosan powder or 5g molecular weight 8000D oligosaccharide powder;

[0081] 2) adding distilled water to the weighed chitosan, the amount of the distilled water being 12 times the weight and volume of the chitosan, and heating up to 65°C under stirring;

[0082] 3) to the solution of step 2), add isopropanol with 3 times of chitosan powder volume weight and glycidyl trimethyl ammonium chloride with 4 times of chitosan powder molar weight, react after 5 hours for standby, the product is white, Insoluble cotton wool;

[0083] 4) Adjust the reaction solution in step 3) with HCl to make its pH value 5.5;

[0084] 5) using distilled water for the reaction solution with a pH value of 5.5 in step 4), dialysis by a dialysis bag with a molecular weight cut-off of 8000, and concentrating after the dialysis;

[0085] 6) Precipitate the concentrated solution with acetone after concentration, separate out white and / or yellow precipitat...

Embodiment 3

[0089] 1) Weigh 5g molecular weight as 5.0×10 5 D chitosan powder or 5g molecular weight 8000D oligosaccharide powder;

[0090] 2) adding distilled water to the weighed chitosan, the amount of the distilled water being 12 times the weight and volume of the chitosan, and heating up to 70°C under stirring;

[0091] 3) to the solution of step 2), add isopropanol with 3 times of chitosan powder volume weight and glycidyl trimethylammonium chloride with 4 times of chitosan powder molar weight, react after 4 hours for standby, the product is white, Insoluble cotton wool;

[0092] 4) Adjust the reaction solution in step 3) with HCl to make its pH value 5.5;

[0093] 5) using distilled water for the reaction solution with a pH value of 5.5 in step 4), dialysis by a dialysis bag with a molecular weight cut-off of 8000, and concentrating after the dialysis;

[0094] 6) Precipitate the concentrated solution with acetone after concentration, separate out white and / or yellow precipitate...

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Abstract

The invention discloses a preparing method and application of polyose quaternary ammonium salt in oceanography engineering technique domain, which comprises the following steps: modify for high and low molecular weight chitose with glycidyl trimethyl ammonium chloride; adopting different condition; preparing hydroxypropyl trimethyl amchlor chitose; proceeding simulation for the structure with infrared spectrum; analyzing for IR spectrogram; replacing with N upper; possessing oxidation resistance desiccating moisture keeping active; setting the active stronger than chitose quaternary ammonium salt. This invention can increase oxidation resistance and desiccating moisture keeping property of the chitose, which can be used as antioxidant and humectant for food and cosmetic product.

Description

technical field [0001] The invention relates to the technical field of marine chemical engineering, in particular to a chitosan quaternary ammonium salt and a preparation method and application thereof. Background technique [0002] Fast-paced work and mental fatigue during the day can easily make the face look haggard and lethargic. In addition, the erosion of harmful substances such as dust and sulfide in the air, as well as the effect of oil and sweat secreted by the skin itself, lead to damage to skin cells and physiological functions. decline. Therefore, applying cosmetics with active ingredients that are easily absorbed by the skin is the best way to maintain and protect the skin. [0003] The trend of advocating nature for cosmetic raw materials continues unabated, and moisturizing agent is an indispensable and important ingredient in cosmetics, which plays a role in moisturizing the skin in cosmetics. There are many types of humectants, among which hyaluronic acid ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A61K8/73A61Q1/00A23L3/3562
Inventor 邢荣娥李鹏程刘松
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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