Stimuli-responsive composite material made from bacterial nano cellulose as well as preparation method and application of stimuli-responsive composite material

A technology of nanocellulose and bacterial cellulose, which is applied in non-active ingredients medical preparations, pharmaceutical formulations, pharmaceutical sciences, etc., can solve high biological toxicity, low biodegradability, surface chemical properties and hydroxyl-rich properties changes, etc. problem, to achieve the effect of low drug permeability and low swelling rate

Active Publication Date: 2014-03-26
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface chemical properties and hydroxyl-rich properties of the bacterial cellulose material obtained in this way will change. In addition, copolymerized monomers such as acrylic acid, acrylamide, and acrylonitrile for grafting have high biological toxicity and low toxicity. The biodegradation performance is not conducive to the use of such composite materials in the field of biomedicine

Method used

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  • Stimuli-responsive composite material made from bacterial nano cellulose as well as preparation method and application of stimuli-responsive composite material
  • Stimuli-responsive composite material made from bacterial nano cellulose as well as preparation method and application of stimuli-responsive composite material
  • Stimuli-responsive composite material made from bacterial nano cellulose as well as preparation method and application of stimuli-responsive composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) The selected chitosan has a characteristic viscosity of 50-800mPa·S, a degree of deacetylation of 92.0%, and its isoelectric point pI is 4.9. When the pH is lower than 4.9, the -NH on chitosan 2 Convert to -NH 3 + The ionization balance of is biased toward -NH3 + , zata potential measurement, as the pH decreases, the charging performance of chitosan increases, when the pH is lower than 3.5, the zeta potential exceeds 80mv, the electrostatic repulsion between molecules is larger, and the response swelling pH is pH lower than 3.5.

[0055] (2) The bacterial cellulose hydrogel membrane with a thickness of 2 mm and a water content ratio of 523.9 g / g (water content: material dry weight) was removed by alkali boiling and water boiling to remove bacterial cells and culture medium. The purified bacterial cellulose membrane was dissolved with an appropriate amount of acetic acid to prepare a 2% (w / v) chitosan solution (pH 5.0), soaked at 50°C for 5 days. Rinse the impregn...

Embodiment 2

[0061] (1) According to Example 1, the bacterial cellulose / chitosan hydrogel prepared in steps (1)-(2) was soaked in 2% (w / v) citric acid buffer for 1 hour, so that chitosan Cross-linking with percitrate ions. Then wash off the residual cross-linking solution on the surface with deionized water.

[0062] (2) The obtained bacterial cellulose / chitosan hydrogel was placed on a polyethylene film, and air-dried in a blast drying oven at 25°C to obtain the bacterial cellulose / chitosan interpenetrating composite dry film B.

[0063] (3) According to the method described in step (4) of Example 1, the rehydration swelling performance test was carried out.

[0064] pH-responsive rehydration characteristics of composite dry film B: (see instructions for swelling rate image 3 , see the physical picture Figure 8 ) After measurement, the composite dry film B, for the composite dry film B between pH 4.0-7.0, does not absorb water and swell, and cannot return to the hydrogel state, and i...

Embodiment 3

[0066] (1) The bacterial cellulose / chitosan hydrogel prepared according to the steps (1)-(2) of Example 1 was soaked in absolute ethanol for 1 hour, so that the chitosan was deposited in the bacterial cellulose network. After the soaked BC was re-soaked in deionized water for 4 hours to replace the ethanol in the hydrogel, the obtained bacterial cellulose / chitosan hydrogel was placed on a polyethylene film and placed in a 25°C blast oven or vacuum Air-dried in a drying oven to obtain a bacterial cellulose / chitosan semi-interpenetrating composite dry film C.

[0067] (2) According to the method described in Example 1, step 4, the rehydration swelling performance test was carried out.

[0068] pH-responsive rehydration characteristics of composite dry film C: (See image 3 ) After testing, the composite dry film C and the composite dry film B between pH 4.0-7.0 do not swell upon water absorption and cannot return to the hydrogel state, and the swelling rates are (2.60, 2.05, 2....

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Abstract

The invention relates to a stimuli-responsive composite material made from bacterial nano cellulose as well as a preparation method and application of the stimuli-responsive composite material. A bacterial nano cellulose base material in a hydrogel state is combined with polyelectrolyte macromolecules in an interpenetrating or semi-interpenetrating manner, and then is wholly or partially dehydrated to obtain the composite material. The composite material is high in rehydration and swelling capacities under the condition of a particular Ph, and keeps the characteristics of low swelling capacity and difficulty in rehydration under the condition of an off-design Ph value. The composite material has the characteristics of temperature response; the pore size of network of the composite material can be controlled, and the penetration rate of solute molecules can be controlled to release a drug in a control manner. Meanwhile, the composite material has the characteristics of high strength, high biocompatibility and the like of the bacterial nano cellulose, and can be applied to smart wound dressings, smart drug carriers, sensors, chemical valves and the like. The composite material has the advantages that the preparation process is simple, the cost is low, and a good application prospect is achieved.

Description

technical field [0001] The invention belongs to the field of bacterial cellulose composite materials, and in particular relates to a bacterial nanocellulose composite material with environmental response and its preparation method and application. Background technique [0002] Bacterial cellulose (BC) is a kind of cellulose secreted by certain bacteria, the most widely used of which is Gluconacetobacter xylinus (also known as Acetobacter xylinus). The bacterial cellulose microstructure is composed of cellulose strips with a width of 30 to 100 nanometers and a thickness of 3 to 8 nanometers interwoven into a random nano-network structure. Compared with plant cellulose, bacterial cellulose has high chemical purity (no lignin, hemicellulose), fine nanostructure, high Young's modulus, high water holding capacity, high crystallinity, good biocompatibility, etc. characteristics, it is regarded as a biomaterial with broad application prospects. [0003] The bacterial cellulose hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/02C08L5/08C08L33/02C08J3/075C08J3/24C08J5/18C08F220/06C08F222/38C08F220/56A61K47/38A61K47/30A61L15/28A61L15/22
CPCA61K9/7092A61K47/38C08L1/02C08L2205/04C08L5/08C08L1/286C08L33/02C08L33/26C08L33/24
Inventor 洪枫张鹏周倩郭香张青松洪特嘉陈琳
Owner DONGHUA UNIV
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