Adsorbent-containing hemostatic devices

A technology of adsorbents and products, applied in the field of inorganic materials and adsorbents, compositions and materials for treating or preventing hemorrhage

Inactive Publication Date: 2009-03-18
UOP LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Introducing the active ingredient into a porous carrier solves a problem encountered with zeolite-containing products such as Z-Medica's QuikClot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] The efficacy of the hemostatic articles of the present invention was tested as shown in the following examples of calcium-exchanged zeolites. Paper sheets were prepared from a mixture (mixed very well) of 4.84 grams of aramid pulp mixed with several liters of water. Then 5.09 grams of calcium ZB-100 zeolite (UOP LLC, Des Plaines, IL) was added and mixed well. Add 0.4526 grams of DADMAC (diallyl-dimethyl ammonium chloride) for further mixing. The mixture was diluted to 3.0 liters with water and fed to the Techpap paper machine. A 100-fold diluted Percol E38 solution containing 0.325 wt-% solids was also added. The sheets are cast, rolled and dried. The hemostatic ability of the paper was then tested according to the following method.

[0043] Blood samples were tested using the following protocol.

[0044] The instrument used was Haemoscope, Morton Grove, Illinois Analyzer. The instrument measures the time until initial fibrin is formed, the kinetics of the initi...

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PUM

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Abstract

The present invention utilizes a combination of a porous carrier and an adsorbent such as a molecular sieve or an inorganic material selected from the group consisting of diatomaceous earth, glass powder or fibers, precipitated or fumed silica, kaolin and montmorillonite clays, and Ca exchanged permutites to make a more effective hemostatic device to treat wounds in mammalian animals. These hemostatic devices provide a lower heat rise to the skin as compared to direct application of zeolites to the skin.

Description

Background of the invention [0001] The present invention generally relates to the hemostatic use of inorganic materials and adsorbents. In particular, the present invention relates to inorganic materials and adsorbents incorporated into an adsorbent medium, such as a nonwoven or film, in which these adsorbents are present in sufficient quantities to prevent blood loss while reducing the amount of water due to adsorption of the adsorbent. The resulting temperature rise is minimized. [0002] Wounds are usually classified as acute or chronic, depending on the treatment orientation. Acute wounds resulting from trauma or surgery include wounds such as actively bleeding wound sites, eg, wounds with detectable, unclotted blood. Rapid control of local bleeding from active bleeding wound sites is important in wound management, especially in the management of trauma, such as that caused by military exercises or surgery. [0003] Conventional methods of hemostasis, such as manual pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00A61M27/00
CPCA61L15/18A61F2013/00255A61F2013/00744A61F13/00034A61F2013/00863A61L2400/04A61L15/425A61F2013/00472A61F2013/00697A61F13/0206A61F2013/00927
Inventor S·A·威尔赫尔R·L·贝达德
Owner UOP LLC
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