655 results about "Ethylene imine" patented technology

One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneamine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneamine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

Polymeric anti-microbial agents produced by substituting the nitrogen atoms in the backbone of ethylenimine polymers are provided. The agents are believed to have low human toxicity while being effective against a variety of pathogens and are useful in applications involving human contact, such as cosmetics, hair care products and textiles, as well as in applications with much less human contact, such as coatings.

A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

The invention belongs to the technical field of semiconductor film preparation, and particularly relates to a preparation method of a zinc-oxide nanorod array film. The technical scheme adopted by the invention is as follows: the preparation method comprises the following steps of: (1) on the basis of adopting height (001)-oriented ZnO as a seed layer, putting the ZnO seed layer into an aqueous solution of zinc nitrate (Zn(NO3)2), polyethyleneimine (PEI) and hexamethylenetetramine (HMT) for epitaxial growth to obtain a (001) preferred-orientation ultralong ZnO nanorod array film; (2) carrying out fast annealing treatment on the film, and improving the photoluminescence performance of the ZnO array film. The technology has the advantages that the continuous growth of the ZnO nanorod at the temperature higher than 100 DEG C can be realized; due to the high-temperature growth condition, the crystallization quality of the nanorod is improved, the internal defects are obviously reduced; the zinc-oxide nanorod array film has excellent photoelectric performance, and is more conductive to being applied in photoelectric devices such as dye-sensitized solar batteries, ultraviolet detectors, field-effect transistors, light-emitting diodes and nanogenerators.

The invention discloses a hydrophobically-modified polyethyleneimine foaming agent capable of releasing carbon dioxide. The hydrophobically-modified polyethyleneimine foaming agent is prepared by reacting polyethyleneimine subjected to hydrophobic modification by a glycidyl ether compound or an alkyl carboxylic compound or a halogenated alkane compound with 0-31% of distilled water at the pressure of 0.1-1 MPa in carbon dioxide at the room temperature for 1-3 days; a 5-40.4 mol% hydrophobic chain is grafted on N atoms in a polyethyleneimine molecular chain of the foaming agent, and a carbamic acid anion (-NCOO-) characteristic absorption peak or a bicarbonate (HCO3-) characteristic absorption peak exists at the range of 159-165 ppm of a C Nuclear magnetic resonance of the foaming agent, and the foaming agent can release carbon dioxide CO2 at the temperature of 50-150 to prepare a polyurethane foam material. The foaming agent provided by the invention can be uniformly dispersed in a preparation raw material of hydrophobic polyurethane foam, can solve a series of problems caused by the fact that non-modified polyethyleneimine is used as a foaming agent, and is climate-friendly.

There are provided amphiphilic biodegradable block copolymers comprising polyethylenimine (PEI) as a hydrophilic block and aliphatic polyesters as a hydrophobic block, which can form various size of polymer aggregates and have very low critical micelle concentration, approximately 10-3 g/l in comparison with low-molecular-weight micelle, and self-assembled polymer aggregates formed from the block copolymers in aqueous milieu, which can be applied to solubilization of insoluble drug and a delivery system of proteins, genes or drugs.

The invention discloses a magnetic nano-adsorbent and a preparation method thereof. The method comprises the following steps: (1) preparing magnetic nano-ferroferric oxide through a coprecipitation method; (2) according to a certain mass proportion, adding the ferroferric oxide, dopamine and polymine into a buffer solution, stirring and reacting for a certain period of time, and after a reaction is finished, cleaning and drying to obtain the magnetic nano-adsorbent. The magnetic nano-adsorbent prepared by the method of the invention has an excellent adsorption effect for anionic dyes, and meanwhile, the magnetic nano-adsorbent has relatively higher alkali resistance and cyclic regeneration capacity. At the same time, the magnetic nano-adsorbent prepared by the invention is capable of selectively adsorbing anionic fractions in a mixed solution.

Methods of applying a sorbent coating on a substrate, a support, and/or a substrate coated with a support are described. One of the methods comprises: (i) optionally, preparing the substrate coated with the support by pre-treating the substrate with a slurry, wherein the slurry comprises: a. solvent, b. a binder, c. the support, and d. optional dispersant; and (ii) treating the substrate, the support, and/or the substrate coated with the support, with a sorbent; wherein the substrate is (a) a monolithic or honeycomb structure made of ceramic, metal, or plastic; (b) a polyurethane foam, a polypropylene foam, a polyester foam, a metal foam, or a ceramic foam; or (c) woven or non-woven plastic or cellulosic fibers, wherein the support is alumina, silica, silica-alumina, titania, zirconia, carbon, zeolite, metal-organic framework (MOF), or combinations thereof, and wherein the sorbent adsorbs carbon dioxide and the sorbent is selected from the group consisting of amines; monoethanolamine; diethanolamine; polyethylenimine (PEI); aminopropyltrimethoxysilane; polyethyleneimine-trimethoxysilane; amide or amine containing polymers including nylon, polyurethane, polyvinylamine, or melamine; and combinations thereof.

The invention relates to a preparation method of pegylation modified hyperbranched poly(ethylene imine) (PEI) coated nano-gold particles, which comprises the following steps: modifying PEI by using mPEG (polyethylene glycol)-COOH, and sequentially carrying out dialysis and freeze-drying on the obtained product so as to obtain PEI-mPEG; taking the solid, dissolving the solid by using water, adding a HAuCl4 solution into the dissolved solid, stirring the obtained product, adding a NaBH4 solution into the obtained product, and carrying out reaction on the obtained mixture at room temperature; and adding triethylamine and acetic anhydride into the obtained object, and after the reaction is completed, carrying out dialysis and freezing on the obtained product so as to obtain pegylation modified hyperbranched polymine coated nano-gold particles. According to the invention, the cheap and easily-obtained PEI is taken as a carrier, so that the cost of materials is reduced; the surface of PEI is modified by using mPEG-COOH, so that the biocompatibility of materials and the colloidal stability of nano-gold particles are improved, and the nano-gold particles are successfully applied to vivo CT (computed tomography) imaging. The method disclosed by the invention is simple in design, mild in reaction conditions and easy to operate, and has an industrialized implementation prospect.

The invention relates to water-soluble fullerene and preparing method thereof, can effectively solve the problems of poor solubility, low photosensitive activity and poor biocompatibility of the conventional fullerene, and adopts the technical scheme that water-soluble polymer polyethylene imine is connected to a fullerene molecule through chemical bonds to obtain water-soluble fullerene; and theweight ratio of polyethylene imine to fullerene is 0.08 to 0.12 : 1. The method comprises the following steps: the fullerene is reacted with an ammoniation reagent to obtain amino fullerene; amino fullerene is reacted with aziridine in such a manner that under the existence of protonated hydrogen ions, aziridine is grafted on amino groups continuously; and finally, the polymer of fullerene and polyethylene imine (namely water-soluble fullerene) is obtained. The water-soluble fullerene prepared according to the invention has the advantages that the characteristics of fullerene are not damaged;the water dispersibility is high; the toxicity is low; the stability is favorable; the preparation method is simple; the cost is low; and the water-soluble fullerene serves as a photosensitizer or a medicine carrier during the preparation of medicines curing cancers.

A novel nano polycation transgenic vector relates to a nano polycation transgenic vector of a cyclodextrin-polyethyleneimine-folacin ternary assembly structure which takes the cyclodextrin as a skeleton material and polymerizes the cyclodextrin after activated with small molecular polyethyleneimine(PEI) as well as couples the decorative folacin on the cyclodextrin-polyethyleneimine to manufacture the nano polycation transgenic vector with tumor targeting. The material composing method of the vector is simple and effective with a high recycling rate; the material is shown to have the characteristics of low poison and high transfecting efficiency by the filtering of a plurality of tumor cell strains and experiences in the body of a rat.

The invention relates to preparation of a magnetic graphene oxide nano-silver composite material with glycopeptide specifically enriched. According to the covalence reaction between graphene oxide and amino ferroferric oxide, magnetic graphene oxide is prepared. The magnetic graphene oxide is used as a carrier, polyethyleneimine is used as a reducing agent and a stabilizer, and nano-silver particles are generated in situ and fixed on the surface of the magnetic graphene oxide. The magnetic graphene oxide nano-silver composite material is used as a hydrophilic stationary phase to be used for specific enrichment of glycopeptide. By means of the preparation method, the magnetic graphene oxide nano-silver composite material is successfully used for hydrophilic enrichment of glycopeptide. The magnetic graphene oxide nano-silver composite material has good application prospects and practical value in the proteomics.

The invention discloses a preparation method and application of a polyethyleneimine modified original ecological positively charged nanofiltration membrane. The preparation method is carried out according to the following steps: (1) using an ultrafiltration membrane as a support membrane, a piperazine and diaminodipropylamine mixed aqueous solution as an aqueous phase and a trimesoyl chloride n-hexane solution as an organic phase to form an active separation layer on the support membrane by interfacial polymerization to obtain an original ecological polyethyleneimine nanofiltration membrane; (2) mixedly dissolving active agent 2-chloro-1-methyliodopyridine, sodium hydroxide and polyethyleneimine in deionized water to obtain a grafted aqueous solution; and (3) pouring the grafted aqueous solution into the surface of the original ecological polyethyleneimine nanofiltration membrane obtained in the step (1) for grafting reaction, then removing excess surface solution, washing with water,and drying to obtain the positively charged nanofiltration membrane. The application of the polyethyleneimine modified original ecological positively charged nanofiltration membrane in removal of dyes, toxic metal ions and monovalent and divalent cations can be provided, and the polyethyleneimine modified original ecological positively charged nanofiltration membrane has good rejection rate and stability.

The invention aims to provide a preparation method of a heavy metal ion absorbent namely polyethyleneimine modified sodium lignin sulfonate. The heavy metal ion absorbent is prepared by grafting polyethyleneimine to sodium lignin sulfonate through static electricity or a chemical crosslinking method, and the property of the absorbent is stable. The surface of the absorbing material synthesized by the provided method is rich in active absorbing groups such as hydroxyl group, sulfonic acid group, amino group, and the like. The heavy metal ion absorbent has the advantages of simple preparation technology, low cost, and good stability, and is easy to promote and use. The provided absorbent has a strong absorbing performance on harmful metal ions such as Pb2+, Cd2+, Cu2+, Ni2+, and the like, and can be used to treat and purify wastewater containing heavy metal ions.

The invention belongs to technology field of carrier material for non-viral gene transfection, and relates to a carrier material for non-viral gene transfection, plasmid DNA compound particle and preparation method and administration. The weight ratio of polyethylene imine and hydrophobic unit containing benzene ring is 1:9-4:6.The polyethylene imine is superbranched polyethylene imine (PEI) with average molecular weight of 1.8K-25K.The hydrophobic unit containing benzene ring is one or more of gamma -benzyl-L-glutamic acid, epsi -carbobenzoxy lysine and phenylalanine at any ratio. The water soluble polyethylene imine modified substance of hydrophobic unit containing benzene ring can compound with genic material to form a particle with positive charge on surface and particle diameter of 50-300nm.The compound particle can transfer loaded genic material into cell to realize expression of genic material and complete transfection process. The invention prepared non-gene transfection carrier material has the advantages of low toxicity and high up transfection efficiency; and can be used as transfection agent in vivo and in vitro.

The invention discloses a nanometer particulate matter modified compound proton exchange membrane and a preparation method thereof. The membrane is compounded by 0.5 to 50 mass percent of surface modified nanometer particles and the balance of proton exchange resin. The preparation method comprises the following steps of: performing surface chemical modification on one of nanometer particles TiO2, SiO2 and TiO2-SiO2 with the particle diameter of 10 to 1,000nm by using a silane coupling agent RSiX3; then coupling with one of naphthalene acid derivatives, benzene sulfonic acid derivatives, NH2CH2(XCH2)mNH2 and ethylenimine; adding the modified nanometer particles into a resin solution to cast a membrane; sequentially soaking in an H2SO4 solution (or H3PO4 solution) and deionized water for 2 hours; and taking out and wiping to obtain the compound membrane.

The invention provides an ion exchange composite film with selectivity on a single cation as well as a preparation method and an application thereof. The composite film comprises a cation ion exchange base film and a polyethyleneimine modified layer, wherein the depositing amount of polyethyleneimine on the cation ion exchange base film is 2.0-200.0 g/m<2>; and the thickness of the ion exchange composite film is 50-500 microns. The single cation is Cu<2+>, Zn<2+>, Ni<2+>, Hg<2+>, Ag<2+>, Pt<2+>, Co<2+> and Cr<3+> and the ion exchange composite film can replace the common ion exchange composite films to be mounted in an electrodialyzer. The ion exchange composite film disclosed by the invention has the advantages of simple operation of a preparation method, green and non-toxic preparation process and adaptation to large-scale industrial production.

The invention discloses a cationic polymer gene vector having low cytotoxicity and high transfection efficiency, which takes multi aldehydesodium alginate (MASA) as a framework and Poly(ethylene imine) PEI as lateral chain, wherein the molecule amount of the PEI is smaller than 2K. The invention further discloses a preparation method and use of the cationic polymer gene vector. The graft copolymer has low cost, low cytotoxicity, low biodegradability, and high transfection efficiency not affected by serum, and is a cationic polymer gene vector having wide application range and good prospect.

The invention relates to a method for preparing gold-silver alloy nanoparticles in a polyelectrolyte multilayer film, which comprises the following steps of: preparing a multilayer film which contains a branched polyethyleneimine or a linear polyethyleneimine and a polyacrylic acid or a polymethylacrylic acid through self-assembly of connecting one layer by one layer; sequentially soaking the multilayer film in aqueous solutions of a chloroauric acid and a silver nitrate; heating the multilayer film absorbed with gold and silver ions in an oven for reduction; and obtaining the gold-silver alloy nanoparticles. The obtained gold-silver alloy nanoparticles have characteristic surface plasmas which resonate to absorb signals, and have very high application value in the fields of catalyst, photics and the like.

The invention discloses a biodegradable film packaging material and a preparation method thereof. The biodegradable film packaging material is prepared from the following components in parts by weight: 45-66 parts of polylactic acid, 20-30 parts of starch, 10-18 parts of polyvinyl alcohol, 8-10 parts of lignin, 0.5-2 parts of sodium humate, 0.5-1 part of poly(ethylene imine) and 4-6 parts of glutaraldehyde. The biodegradable film packaging material prepared by using the method disclosed by the invention is favorable in crystallinity, mechanical strength and elongation at break, free of special treatment on the surface, good in film surface tension and capable of favorably bonding ink and the film packaging material.