Preparation method and uses of biodegradable high mechanical strength organic/inorganic composite hydrogel

An inorganic composite, hydrogel technology, applied in the field of biomedical composite materials, can solve the problems of lack of cell affinity and hydrophilicity, difficult to obtain hydrogel system, poor tissue compatibility, etc., to achieve improved mechanical properties, The effect of improving osteoinductive activity and osteogenic ability, and enhancing mechanical properties

Active Publication Date: 2013-05-08
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metal prostheses have problems such as looseness, fracture, poor tissue compatibility, and non-degradability
Some degradable polymers have the following problems as bone repair materials: lack of good cell affinity and hydrophilicity, low mechanical strength, etc.
However, this method is still difficult to obtain a practical hydrogel system

Method used

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  • Preparation method and uses of biodegradable high mechanical strength organic/inorganic composite hydrogel
  • Preparation method and uses of biodegradable high mechanical strength organic/inorganic composite hydrogel
  • Preparation method and uses of biodegradable high mechanical strength organic/inorganic composite hydrogel

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preparation example Construction

[0052] In the first embodiment of the preparation method of the present invention, step (1) preparation of peroxidized micellar polyacrylamide hydrogel includes the following sub-steps:

[0053] ① prepare polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer micellar aqueous solution, transfer it to a glass container, the container can be a large cylindrical glass test tube, under the condition of ventilation, pass the pre- Radiation methods, such as using 60 Co gamma-ray irradiation obtains a peroxidized surfactant solution, wherein the concentration of the aqueous solution of block copolymer micelles is preferably 5 to 15 g / L, also preferably 6 to 14 g / L, even more preferably 8 to 12 g / L L, most preferably 10g / L, described block copolymer can be EO for example 106 PO 70 EO 106 ;

[0054] ②Preparing acrylamide monomer or aqueous solution, it is preferably prepared into a solution of 3-10M, preferably 4-8M, more preferably 5-7M;

[0055] ③Mix the peroxidized su...

Embodiment 1

[0092] (1) Preparation of peroxidized micellar polyacrylamide hydrogel

[0093] ① Prepare 100mL of PF 127 aqueous solution with a concentration of 10g / L, transfer it to a large cylindrical glass test tube of 150mL, and use 60 Co gamma-ray irradiation for 8 hours, the irradiation dose rate was 2.5kGy / h, and a peroxidized surfactant solution was obtained;

[0094] ② Prepare 7M aqueous solution of acrylamide monomer solution;

[0095] ③Take 50mL of peroxidized surfactant solution and 100mL of monomer solution and mix evenly, take 12mL of the mixed solution and transfer it to a glass plate mold, place it in a vacuum desiccator, vacuumize the container and pass nitrogen gas into it, and cycle 3 times ;

[0096] ④Place the reaction container in an environment of 50°C for reaction. The peroxide decomposes under heating conditions to generate free radicals, which initiates monomer polymerization. The reaction time is 36 hours, and a hydrogel is obtained. The appearance photos and ...

Embodiment 2

[0105] (1) Preparation of peroxidized micellar acrylamide hydrogel

[0106] ① Prepare 100mL of PF 127 aqueous solution with a concentration of 10g / L, transfer it to a large cylindrical glass test tube of 150mL, and use 60 Co gamma-ray irradiation for 8 hours, the irradiation dose rate was 2.5kGy / h, and a peroxidized surfactant solution was obtained;

[0107] ②Take 50mL of peroxidized surfactant solution to dissolve acrylamide monomer, add monomer and water to prepare 150mL of 6M acrylamide solution, transfer 12mL of the solution to a glass plate mold, and place it in a vacuum desiccator , after vacuumizing the container, nitrogen gas was introduced, and the cycle was repeated 3 times;

[0108] ③Put the reaction container in an environment of 50°C for reaction, the peroxide decomposes under heating conditions to generate free radicals, trigger monomer polymerization, and the reaction time is 36 hours to obtain a hydrogel.

[0109] (2) Cycle freeze-thaw treatment of peroxi...

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Abstract

The present invention relates to a preparation method and uses of a composite hydrogel containing hydroxyapatite (HAP) nanoparticles, wherein an inorganic component in the composite hydrogel is HAP nanoparticles prepared in an in situ manner, an organic matrix in the composite hydrogel is an overoxidation micelle (pMIC) polyacrylamide gel prepared by using a pre-irradiation method, an overoxidation linear polymer chain polyacrylamide gel or a polyvinyl alcohol gel, and a mass ratio of the HAP to the polymer in the composite hydrogen is 1:5-1:3. According to the present invention, a freezing-defrosting circulation method is adopted to treat a gel, and an electrophoresis method is adopted to generate HAP nanoparticles inside the gel in an in situ manner, such that the HAP nanoparticles are uniformly dispersed in the gel, and HAP having a hollow sphere structure is obtained so as to enhance mechanical property and improve biological activity, such that potential application values in articular cartilage repair and tissue engineering materials are provided.

Description

technical field [0001] The present invention relates to a biodegradable high mechanical strength organic / inorganic composite hydrogel, which contains hydroxyapatite (HAP) nanoparticles. The present invention also relates to the preparation method and application of the composite hydrogel, belonging to biological field of medical composite materials. Background technique [0002] Artificial bone repair and replacement materials mainly include three types: metal materials (including medical metal materials such as titanium-based alloys and cobalt-based alloys); polymer materials (including polyethylene, polylactic acid, etc.); glass ceramics, calcium phosphate-based bioceramics, etc.). Metal prostheses have problems such as loosening, fracture, poor tissue compatibility, and non-degradability. Some degradable polymers have the following problems as bone repair materials: lack of good cell affinity and hydrophilicity, low mechanical strength and other shortcomings. Scaffolds...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L51/08C08L29/04C08K3/32C08F283/06C08F220/56C08F271/02C08J3/075C25D15/00
Inventor 李志勇贺昌城汪辉亮苏允兰王笃金
Owner INST OF CHEM CHINESE ACAD OF SCI
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