Double-photoresponse type zinc oxide, preparation method thereof and photosensitive coating with antibacterial osteogenesis

A photosensitive coating and photoresponsive technology, applied in zinc oxide/zinc hydroxide, coating, medical science, etc., can solve the problems of implant falling off, poor bonding of surrounding bone tissue, and no antibacterial performance, etc., and achieve good adsorption , antibacterial properties and good light and heat stability, the effect of improving antibacterial ability

Inactive Publication Date: 2020-09-11
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Bacterial infection is most closely related to PIDs of implants, which will lead to weak osseointegration around implants, implant detachment, and eventually implant failure, so that edentulous patients not only need more additional operations for PIDs, sometimes even It is necessary to undergo a second implant surgery

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  • Double-photoresponse type zinc oxide, preparation method thereof and photosensitive coating with antibacterial osteogenesis
  • Double-photoresponse type zinc oxide, preparation method thereof and photosensitive coating with antibacterial osteogenesis
  • Double-photoresponse type zinc oxide, preparation method thereof and photosensitive coating with antibacterial osteogenesis

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preparation example Construction

[0039] The invention provides a preparation method of dual-photoresponsive zinc oxide, comprising the following steps:

[0040] (1) Mix soluble zinc salt, hexamethylenetetramine and water for the first hydrothermal reaction, then mix the reaction feed liquid with sodium citrate, hydroxypropyl methylcellulose, photothermal conversion material and lignin Carrying out the second hydrothermal reaction to obtain a hydrothermal product;

[0041] (2) The hydrothermal product is subjected to freeze-drying and microwave irradiation in sequence to obtain a dual-photoresponsive zinc oxide.

[0042] Unless otherwise specified, the water used in the present invention is deionized water.

[0043] The present invention mixes soluble zinc salt, hexamethylenetetramine (HMT) and water to carry out the first hydrothermal reaction. In the present invention, the soluble zinc salt is preferably zinc nitrate, specifically zinc nitrate hexahydrate; the water is preferably deionized water; the tempe...

Embodiment 1

[0057] 50mmol (1.4875g) Zn (NO 3 ) 2 ·6H 2 O. 25 mmol (0.3505 g) of HMT was dissolved in 100 mL of deionized water, and stirred for 10 min under a sealed seal. After heating in a water bath at 65°C for 15min, add 0.14g Na 3 C 6 h 5 o 7 , 0.1g HPMC, 0.025g activated carbon and 0.1g lignin, keep the water bath at 85°C for 10h. Wash twice with absolute ethanol and twice with deionized water, all of which are centrifugally washed at a speed of 7000rpm, and the washing time is 15min, and then pre-frozen at -80°C and then vacuum freeze-dried for 12h, and the resulting product is subjected to microwave irradiation. The power of microwave irradiation is 800W, and the time is 15min to obtain double photoresponsive ZnO powder. Subsequent tests were carried out with the ZnO prepared in Example 1.

Embodiment 2

[0059] 1. Preparation of Ti-ZC: Add the ZnO powder and type I collagen powder prepared in Example 1 into phosphate-buffered saline solution (PBS buffer) according to the mass ratio of 1:1, and stir at 75rpm for 2h to obtain a suspension , the concentration of ZnO powder in the suspension is 200 μg / mL, the suspension is added dropwise on the surface of a titanium sample (a titanium sheet with a diameter of 10 mm and a thickness of 1 mm), dried at room temperature, and the coated titanium sample is designated as Ti-ZC.

[0060] 2. Preparation of Ti-ZnO: Others are the same as in 1, except that type 1 collagen powder is not added, the concentration of ZnO in the suspension is 200 μg / mL, and the obtained sample is recorded as Ti-ZnO.

[0061] 3. Preparation of ZnO-Col-I: Using PBS buffer, mix ZnO and Col-I with the same concentration (200μg / ml) and shake in a shaker at a speed of 75-80rpm for 2-3 hours to prepare ZnO-Col-I. Col-I suspension, the obtained sample is recorded as ZnO-...

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Abstract

The invention relates to the technical field of surgical implants, and provides double-photoresponse type zinc oxide, a preparation method thereof, and a photosensitive coating with antibacterial osteogenesis. In the preparation process of zinc oxide, sodium citrate and hydroxypropyl methyl cellulose are added to control the morphology, a photothermal conversion material is added to enable zinc oxide to have photothermal conversion capacity, and lignin is added to reduce the energy band gap of zinc oxide; and the freeze-dried hydrothermal product is carbonized through microwave irradiation, and the energy band gap is further reduced, so that the material has response capability to yellow light. The zinc oxide prepared by the invention is of a tremella-shaped wrinkle structure, has dual response to yellow light and near-infrared light, has good adsorbability, antibacterial property and photo-thermal stability, and has photo-thermal conversion capability. The zinc oxide has antibacterialproperty and osteogenesis property, can effectively improve the antibacterial and osteogenesis capacity of the implant when being applied to the surface of the implant, and can realize the light-operated effect and on-demand effect of the antibacterial and osteogenesis functions of the implant due to the special photosensitivity of the coating.

Description

technical field [0001] The invention relates to the technical field of surgical implants, in particular to a dual-photoresponsive zinc oxide, a preparation method thereof, and a photosensitive coating with antibacterial and osteogenic properties. Background technique [0002] Oral implant surgery is one of the most common implant procedures performed in humans, and at the same time, the number of patients affected by peri-implant diseases (PIDs) is also increasing. Different from the conventional fully closed implant system, the incidence of oral implant surrounding diseases is as high as about 40%. This is due to the partial exposure of the implant to the oral microenvironment, which can easily cause bacterial invasion and peri-implant mucositis (PIM); further spread of inflammation can lead to a gradual loss of supporting bone around the implant, which in turn leads to peri-implantitis (PI) happened. Bacterial infection is most closely related to PIDs of implants, which ...

Claims

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Application Information

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IPC IPC(8): C01G9/02A61L27/30A61L27/54A61L27/06
CPCC01G9/02A61L27/306A61L27/54A61L27/06A61L2300/102A61L2300/404A61L2430/12A61L2420/02A61L2300/412C01P2004/61C01P2006/16C01P2006/14C01P2006/12C01P2004/03C01P2002/72C01P2002/84C01P2002/82
Inventor 廖岚王小磊赵思语
Owner NANCHANG UNIV
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