34results about How to "Strong light-to-heat conversion ability" patented technology

The invention provides a single light-activated nano particle and a preparation method and application thereof, and belongs to the technical field of medicine. The single light-activated nano particlecomprises a hollow bismuth selenide nano particle, a phase-change material and a radical initiator, wherein the phase-change material and the radical initiator are loaded in the hollow bismuth selenide nano particle. The single light-activated nano particle is in laser radiation, absorbed light energy is converted to hyperthermia, cancer cells are directly killed, the phase-change material further can be prompted to melt, so that the radical initiator is released and split, generated free radical can cause cell membrane lipid peroxidation, glutathione is consumed, DNA is damaged, and thus thecancer cells are removed further. By detecting in vitro cytotoxicity and in vivo anti-cancer function, it is proved that the single light-activated nano particle has superior tumor killing capacity,and efficient photo-thermal and photodynamic combined therapy is realized through the hyperthermia and hyperthermia cascade activated free radical.

The invention provides a core-shell gold nano-particle capable of intensifying the photo-thermal transformation effect. The novel core-shell structure gold nano-particle is composed by using gold as a shell and medicines as a core and loading acid radical medicines in the hollow structure of the hollow gold nano-particle, and is absorbed by a characteristic peak in a near infrared region with the wavelength of 700-900nm, wherein the particle diameter is 30-200nm. In the photo-thermal action, the structure of the gold nano-particle becomes loose to trigger release of medicines and play the effect of chemotherapy. The core-shell gold nano-particle shows an intensified photo-thermal transformation capability under near infrared light (wavelength of 700-900nm) radiation to generate a thermal-therapy effect on a tumor site, and can generate double effects of thermal therapy and chemo therapy; and the two treatment modes synergetically act, and are conductive to killing tumor cells comprehensively and completely. The core-shell gold nano-particle is capable of remarkably improving the effect for treating tumors, and can be applied to preparation of tumor treatment medicaments.

The invention provides a conjugated polymer material that regulates carbon dioxide adsorption based on the photothermal effect. The structural formula of the conjugated polymer material is shown in formula 1. Wherein R is a functional group containing guanidine group, azido group and polyethyleneimine (PEI), A is a six-membered aromatic ring containing 0-3 N atoms, and the number of structural units n is 4-60. The conjugated polymer has high surface energy and large specific surface area, and the adsorption capacity for carbon dioxide reaches 0.8mmol / g. The polymer has a strong absorption near 808nm, and has a strong light-to-heat conversion ability, with a conversion efficiency of 15%-35%. The polymer has the dual characteristics of gas adsorption and photothermal conversion, and can dynamically control the adsorption and release of carbon dioxide by near-infrared light, showing the excellent application prospects of pyrrolopyrrole-type conjugated polymers in gas adsorption.

The invention relates to a composite quaternary hydrogel capable of achieving high solar evaporation rate, comprising a polyvinyl alcohol gel matrix skeleton, a carbon-based Chinese ink coating and a titanium dioxide coating; wherein there are multiple polyvinyl alcohol gel matrix skeletons A gel internal channel, the carbon-based Chinese ink coating is composed of nanoparticles; the lower surface of the carbon-based Chinese ink coating is attached to the upper surface of the polyvinyl alcohol gel matrix skeleton, and the upper surface of the carbon-based Chinese ink coating is attached to conformal titanium dioxide The lower surface of the coating, the upper surface of the conformal titanium dioxide coating is attached to the lower surface of the titanium dioxide coating. The beneficial effects of the present invention are: facilitating the in-situ conversion and utilization of solar energy; improving the efficiency of solar seawater evaporation and desalination; effectively enhancing the water transport capacity of the gel, and having the function of stabilizing the carbon-based Chinese ink coating; overcoming the previous solar evaporation In the design, the solar energy loss is too large, and the evaporation energy is too low, so the evaporation rate is low.

The invention discloses a platinum-based single-atom nanozyme for combined tumor therapy and a preparation method thereof. Using cisplatin and 3,4-diaminopyridine as precursors, a platinum (IV)-based enzyme is prepared by oxidative polymerization reaction. Single-atom nanozyme drugs. Compared with the prior art, the platinum (IV)-based single-atom nano-enzyme drug prepared by the present invention has both catalase-like and peroxidase-like activities, which can greatly relieve tumor hypoxia and consume excess energy in tumors. The expressed glutathione can also promote the generation of free radicals in tumor cells, reduce toxic and side effects, and improve the therapeutic effect of radiotherapy. In addition, the nanozyme has strong absorption in the entire near-infrared region. As a photothermal conversion agent, it can absorb 808nm laser light and convert it into high-energy heat, which greatly improves the killing power to tumor cells and realizes photothermal therapy. Therefore, platinum (IV) )-based single-atom nanozyme drugs have a strong killing effect on tumor cells due to their synergistic effects of hyperthermia and radiotherapy.