34results about How to "Strong light-to-heat conversion ability" patented technology

The invention provides a carbon material microbead / polymer composite film, and a preparation method and applications thereof. The carbon material in the carbon material microbead / polymer composite film is carbon nanotube microbead or graphene microbead, the carbon material microbead is of a hierarchical pore structure, the polymer is polyacrylic acid and a derivative of polyacrylic acid, polyvinylalcohol, sodium alginate or chitosan, and the composite film also comprises a hydrophilic film. According to the preparation method, micro fluidic method and carbon material calcining are adopted, the carbon material microbead and the polymer aqueous solution are mixed to be uniform, after immersion, an obtained mixture is poured onto the hydrophilic film, filtering, and crosslinking are carriedout so as to obtain the carbon material microbead / polymer composite film. The preparation method is simple in operation, and is friendly to the environment; the obtained composite film is used for solar energy driven water evaporation; and water evaporation speed reaches 1.62kg / m2 / h.

The invention belongs to the field of pharmaceutical preparations. The invention relates to a preparation method and application of a macrophage membrane coated arginine deiminase / catalase / IR780 nanoparticle. The prepared macrophage membrane coated arginine deiminase / catalase / IR780 nanoparticle is good in biocompatibility, the preparation method is simple, the particle size distribution of the nanoparticle is uniform, the stability of the arginine deiminase can be improved, the protease hydrolysis resistance ability of the arginine deiminase is improved, an anti-tumor effect is enhanced in cooperation with photothermal therapy or photodynamic therapy, and a potential application value is achieved in the fields of treatment of cancers (especially arginine-dependent diseases) and the like.

The invention provides a method for preparing carbon / calcium phosphate / ferroferric oxide composite structured nano particles, and application of the nano particles. The method comprises the following steps: by taking calcium hydroxide, polyacrylic acid, isopropanol, ferrous chloride and diammonium phosphate as raw materials, performing calcining, mixing, drying and the like, thereby obtaining the carbon / calcium phosphate / ferroferric oxide composite structured nano particles by using the simple method. The prepared product is uniform in particle size, high in photo-thermal conversion efficiency and good in biocompatibility, and has very good application prospects in fields such as photo-thermal treatment, medicine conveying and biological imaging.

The invention discloses a multi-intelligence responsiveness microcapsule. The multi-intelligence responsiveness microcapsule is prepared from aliphatic polyamine polyurethane and ferroferric oxide, wherein each of the aliphatic polyamine polyurethane and the ferroferric oxide is of a laminated structure and a plurality of layers of the aliphatic polyamine polyurethane and the ferroferric oxide arearranged; the aliphatic polyamine polyurethane layers and the ferroferric oxide layers are alternately assembled together layer by layer to form the aliphatic polyamine polyurethane / ferroferric oxideintelligence response hollow microcapsule; the surface of the microcapsule is modified by an anti-tumor hydrophilic drug. The invention further discloses application of the microcapsule serving as acarrier for delayed release of the drug, and a preparation method of the microcapsule. The multi-intelligence response microcapsule is prepared by utilizing a layer-to-layer self-assembling method; the method is simple and convenient and low cost; the multi-intelligence response type microcapsule has excellent multi-response performance including pH (Potential of Hydrogen), temperature, near infrared, magnetic response and the like and good biocompatibility; a cancer treatment drug doxorubicin hydrochloride is modified on the surface of the microcapsule so that the target property and the utilization rate of the drug are enhanced; the multi-intelligence responsiveness microcapsule has a good application prospect in the field of controlled release of the multi-intelligence response drugs.

The invention provides a single light-activated nano particle and a preparation method and application thereof, and belongs to the technical field of medicine. The single light-activated nano particlecomprises a hollow bismuth selenide nano particle, a phase-change material and a radical initiator, wherein the phase-change material and the radical initiator are loaded in the hollow bismuth selenide nano particle. The single light-activated nano particle is in laser radiation, absorbed light energy is converted to hyperthermia, cancer cells are directly killed, the phase-change material further can be prompted to melt, so that the radical initiator is released and split, generated free radical can cause cell membrane lipid peroxidation, glutathione is consumed, DNA is damaged, and thus thecancer cells are removed further. By detecting in vitro cytotoxicity and in vivo anti-cancer function, it is proved that the single light-activated nano particle has superior tumor killing capacity,and efficient photo-thermal and photodynamic combined therapy is realized through the hyperthermia and hyperthermia cascade activated free radical.

The invention discloses a polylactic acid-based photo-thermal film and a preparation method thereof. The method comprises the following steps: dissolving polylactic acid and polylactic acid modified lignin in a volatile organic solvent according to a certain mass ratio, preparing a matrix film from the obtained mixed solution by using an electrostatic spinning technology, and then spraying a polydopamine modified alum disulfide solution on the two sides of the matrix membrane by using a spraying technology. The photo-thermal thin film obtained through the method has thermal stability and more excellent photo-thermal conversion capacity, and the application range of the photo-thermal thin film in the solar interface evaporation field and the thermoelectric conversion field is widened.

The invention relates to a preparation method of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals. The preparation method comprises the following steps:(1) preparing a CNC solution from plant raw materials by using an acid hydrolysis method; (2) introducing iron ions with different valence states into the CNC solution, and synthesizing magnetic nanoparticles in situ under an alkaline condition to obtain a colloidal solution; and (3) adding a polymer monomer, an initiator, a cross-linking agent and a catalyst into the colloidal solution obtained in the step (2), and reacting to obtain the target product. Compared with the prior art, the CNC solution is taken as a raw material, in-situ growth of the magnetic nanoparticles is taken as a basis, and different types of polymers with different contents are added, so that preparation of photo-thermal response drug-loaded hydrogel and light-operated drug release can be realized.

The invention provides a conjugated polymer material for regulating carbon dioxide adsorption based on a photothermal effect. The structural formula of the conjugated polymer material is as shown in formula 1, wherein R is a functional group containing a guanidine group, an azide group, and polyethyleneimine (PEI), A is a six-membered aromatic ring containing 0-3 N atoms, and the number n of structural units is 4-60. A conjugated polymer has high surface energy and a large specific surface area, and has an adsorption capacity for carbon dioxide of 0.8mmol / g. The polymer has strong absorption near 808nm, the photothermal conversion ability is high, and the conversion efficiency is 15%-35%. The polymer has the dual characteristics of gas adsorption and photothermal conversion, can dynamically control the adsorption and release of carbon dioxide through near-infrared light, and demonstrates excellent application prospects of pyrrolopyrrole type conjugated polymers in gas adsorption. (Please see the specification for the formula).

The invention discloses a nanofiber for treating a bacterial infection diabetes wound surfaceand a preparation method and application thereof. The nano-fiber comprises a core curcumin nano-crystal and a shell polydopamine nano-tube. The used natural product curcumin has good biological safety, can induce M2 type polarization of macrophages, and further promotes wound healing. The polydopamine material has the advantages of excellent biocompatibility, good near-infrared conversion performance, remarkable photo-thermal antibacterial effect and the like. The nanofiber is simple in preparation process, low in cost, good in repeatability and suitable for large-scale production. The prepared nanofiber has good antibacterial and diabetes wound repair promoting capabilities, and has very high clinical application value.

The invention relates to a composite quaternary hydrogel capable of realizing a high solar evaporation rate. The composite quaternary hydrogel comprises a polyvinyl alcohol gel matrix skeleton, a carbon-based Chinese ink coating layer and a titanium dioxide coating layer, wherein a plurality of gel internal pore channels exist in the polyvinyl alcohol gel matrix skeleton, and the carbon-based Chinese ink coating layer is composed of nanoparticles; the lower surface of the carbon-based Chinese ink coating layer is attached to the upper surface of the polyvinyl alcohol gel matrix skeleton, the upper surface of the carbon-based Chinese ink coating layer is attached to the lower surface of the conformal titanium dioxide coating layer, and the upper surface of the conformal titanium dioxide coating layer is attached to the lower surface of the titanium dioxide coating layer. The composite quaternary hydrogel has the beneficial effects that in-situ conversion and utilization of solar energy are facilitated; the solar seawater evaporation desalination efficiency is improved; the water transport capacity of the gel is effectively enhanced, and the function of stabilizing the carbon-based Chinese ink coating layer is achieved; and the defects that in an existing solar evaporation design, solar energy loss is too large, evaporation energy is too low, and thus the evaporation rate is low are overcome.

The invention discloses a portable alkaline phosphatase detection kit based on temperature change and application thereof. The portable alkaline phosphatase detection kit comprises manganese dioxide nanoflakes, L-ascorbic acid-2-trisodium phosphate salt, dopamine and a buffer solution. The detection kit utilizes a portable near-infrared laser to irradiate reaction products; based on the temperature change of the reaction products, sensitive detection of a target can be realized through a low-cost thermometer or discoloration temperature measuring patches; and the portable alkaline phosphatasedetection kit can be used for detecting alkaline phosphatase, and has the advantages of simplicity and convenience, quickness, good selectivity, high sensitivity and the like.

The invention relates to a preparation method of a flexible fluoride-free super-hydrophobic coating with photothermal conversion and heat storage functions. According to the method, polydimethylsiloxane is introduced as an adhesive, the adhesive and a phase change material are dissolved in a solvent, then carbon-doped mesoporous silica nanotubes are dispersed in the system, and finally a blended solution is sprayed on a substrate in a spraying manner, so that the flexible fluorine-free super-hydrophobic coating with photothermal conversion and heat storage functions is obtained. The process of preparing a composite phase change material and hydrophobic modification is omitted, and the coating not only has excellent photothermal conversion capacity, but also has good flexibility and excellent super-hydrophobic performance, is simple to construct and low in preparation cost, and has huge practical application value.

The invention discloses a degradable anti-tumor nano-medicine based on limotherapy, as well as a preparation method and application thereof, and belongs to the technical field of nano-medicines. The preparation method comprises the following steps: dissolving dopamine hydrochloride in a Tris-HCl buffer solution, adding glucose oxidase into the mixture, and performing quick stirring; filtering themixture through a 0.45[mu]m water filter membrane, continuing to quickly stir the solution after filtering, and filtering the mixture through the 0.45[mu]m water filter membrane; centrifuging the secondary filtered liquid with a silver cubic solution prepared isometrically, performing precipitating and mixing, performing ultrasonic and standing treatment on the mixed solution, and performing centrifuging to obtain precipitation; resuspending the precipitation in a PBS buffer solution to obtain a glucose oxidase-loaded silver nano-cube. The particle glucose oxidase has a loading capacity of 10-25 percent and an average particle size of 100-150nm, is acidic in a tumor part and can be degraded in a hydrogen peroxide environment, and can achieve the EPR effect and a quick internal cleaning function; and an excellent tumor treatment effect is showed by combining the limotherapy of consuming glucose in the tumor part by the glucose oxidase and a photothermal therapy of the nano-silver cube.

The invention discloses a platinum-based monatomic nano-enzyme for combined treatment of tumors and a preparation method thereof, cis-platinum and 3, 4-diaminopyridine are used as precursors, and a platinum (IV)-based monatomic nano-enzyme drug is prepared through oxidative polymerization reaction. Compared with the prior art, the platinum (IV)-based monatomic nano-enzyme medicine prepared by the invention has both catalase-like and peroxidase-like activities, can relieve hypoxia of tumors to a great extent, consumes over-expressed glutathione in the tumors, and can promote generation of free radicals in tumor cells, reduce toxic and side effects and improve the radiotherapy treatment effect. The nano-enzyme has strong absorption in the whole near-infrared region, and can absorb 808nm laser and convert the laser into high-energy heat as a photothermal conversion agent, so that the lethality to tumor cells is greatly improved, and photothermal therapy is realized, and therefore, the thermotherapy and radiotherapy functions of the platinum (IV)-based monatomic nano-enzyme drug synergistically have a relatively strong killing effect on the tumor cells.

The invention discloses a portable alkaline phosphatase detection kit based on temperature change and application thereof. The portable alkaline phosphatase detection kit comprises manganese dioxide nanoflakes, L-ascorbic acid-2-trisodium phosphate salt, dopamine and a buffer solution. The detection kit utilizes a portable near-infrared laser to irradiate reaction products; based on the temperature change of the reaction products, sensitive detection of a target can be realized through a low-cost thermometer or discoloration temperature measuring patches; and the portable alkaline phosphatasedetection kit can be used for detecting alkaline phosphatase, and has the advantages of simplicity and convenience, quickness, good selectivity, high sensitivity and the like.

The invention provides cell-penetrating peptide modified drug-loaded thermosensitive nanoparticles and application thereof in resisting melanoma, and belongs to the technical field of nano biomedicine. According to the cell-penetrating peptide modified drug-loaded thermosensitive nanoparticles, TSL is used as a carrier, and under the modification of cell-penetrating peptide TAT, the chemotherapy effect of TMZ and the PTT treatment effect of IR820 are combined to construct a novel thermosensitive nanoparticle TAT-TSL-IR820-TMZ with a synergistic anti-tumor effect, so that targeted delivery of treatment components is realized. In-vitro experiments show that the nanoparticles can be massively taken by melanoma cells, can target lysosome, and can play a role in combined chemotherapy and photothermal action in combination with NIR.

The invention provides a large-area nano carbon material and a preparation method thereof, and belongs to the technical field of nano carbon materials. According to the invention, the oxidation-reduction potential difference between a nanocarbon dispersion liquid and metal is used as driving force, the metal is used as a substrate, in-situ self-assembly growth is carried out under simple and mild conditions (room temperature or low temperature of 20-100 DEG C, and high temperature is not needed), the large-area nanocarbon material supported and loaded by the metal is obtained, raw material consumption is low, operation is simple and easy, and expansibility is high. The nano carbon material is not limited by instruments (a drying oven, a heating plate and the like), can be directly made into multiple forms such as a tubular form, a sheet form and a foam form, is used in the fields of energy chemistry and environmental chemistry, and can etch a metal substrate as required to prepare a regular and uniform multi-form large-area nano carbon material without metal support for application.

The invention belongs to the technical field of biomedical materials, and in particular relates to a mesoporous polydopamine (MPDA) nanoparticle used for tumor T1-T2 magnetic resonance imaging. Mesoporous polydopamine nanoparticles with imaging effects. The present invention adopts a doping method before polymerization, uses dopamine hydrochloride and Mn precursors as basic raw materials, and prepares a manganese-mesoporous polydopamine nanoparticles as templates with F127 and TMB. The particle is a polydopamine nanoparticle doped with metal manganese and has a mesoporous structure. It has tumor microenvironment responsiveness, good photothermal conversion ability, and good photothermal stability; it has good biocompatibility. It can be used as both T1 and T2 contrast agent for magnetic resonance imaging of tumors.

The present invention relates to a preparation method of a photothermal response drug slow-release hydrogel based on magnetic cellulose nanocrystals, comprising the following steps: (1) preparing a CNC solution from a plant material by acid hydrolysis; (2) adding it to the CNC solution, Introduce iron ions of different valence states, and synthesize magnetic nanoparticles in situ under alkaline conditions to obtain a colloidal solution; (3) add polymer monomers, initiators, crosslinking agents and Catalyst, reaction, that is, to obtain the target product. Compared with the prior art, the present invention uses CNC solution as the raw material, based on the in-situ growth of magnetic nanoparticles, and by adding different contents and different types of polymers, the preparation of photothermally responsive drug-loaded hydrogels and photothermal response can be realized. controlled drug release.

The invention discloses a photo-thermal ionic gel film as well as preparation and application thereof, and belongs to the field of flexible electronic and photo-thermal and thermoelectric functional materials. The photo-thermal power generation ionic gel film comprises two parts, wherein one part is an ionic gel film prepared from an acrylate monomer, a cross-linking agent, an ionic conductive filler and a photoinitiator through a photo-crosslinking reaction; and the other half is an ionic gel film formed by adding a photo-thermal conversion material into the ionic gel film. The two ionic gel films are obtained by adding various precursors into a mold and carrying out copolymerization reaction under the irradiation of an ultraviolet lamp. Under an illumination condition, the ionic gel film can form an internal temperature difference, so an internal potential difference is formed, and power generation is realized. The photo-thermal ion gel film provided by the invention has the advantages of simplicity in preparation, easiness in obtaining raw materials, convenience in large-scale production and the like.

The invention provides a conjugated polymer material that regulates carbon dioxide adsorption based on the photothermal effect. The structural formula of the conjugated polymer material is shown in formula 1. Wherein R is a functional group containing guanidine group, azido group and polyethyleneimine (PEI), A is a six-membered aromatic ring containing 0-3 N atoms, and the number of structural units n is 4-60. The conjugated polymer has high surface energy and large specific surface area, and the adsorption capacity for carbon dioxide reaches 0.8mmol / g. The polymer has a strong absorption near 808nm, and has a strong light-to-heat conversion ability, with a conversion efficiency of 15%-35%. The polymer has the dual characteristics of gas adsorption and photothermal conversion, and can dynamically control the adsorption and release of carbon dioxide by near-infrared light, showing the excellent application prospects of pyrrolopyrrole-type conjugated polymers in gas adsorption.

The invention relates to a composite quaternary hydrogel capable of achieving high solar evaporation rate, comprising a polyvinyl alcohol gel matrix skeleton, a carbon-based Chinese ink coating and a titanium dioxide coating; wherein there are multiple polyvinyl alcohol gel matrix skeletons A gel internal channel, the carbon-based Chinese ink coating is composed of nanoparticles; the lower surface of the carbon-based Chinese ink coating is attached to the upper surface of the polyvinyl alcohol gel matrix skeleton, and the upper surface of the carbon-based Chinese ink coating is attached to conformal titanium dioxide The lower surface of the coating, the upper surface of the conformal titanium dioxide coating is attached to the lower surface of the titanium dioxide coating. The beneficial effects of the present invention are: facilitating the in-situ conversion and utilization of solar energy; improving the efficiency of solar seawater evaporation and desalination; effectively enhancing the water transport capacity of the gel, and having the function of stabilizing the carbon-based Chinese ink coating; overcoming the previous solar evaporation In the design, the solar energy loss is too large, and the evaporation energy is too low, so the evaporation rate is low.

The invention provides a drug-loaded nano-particle for hepatic artery chemoembolization. The drug-loaded nano-particle is a novel doxorubicin-loaded metal organic framework (MOF) nano-particle; and a UiO-66 / Bi2S3 nano-composite, and a preparation method thereof. The preparation method of the drug-loaded nanoparticles comprises the following steps: mixing UiO-66 / BiS with a DOX solution, stirring overnight in a dark environment at room temperature, centrifuging, and washing with deionized water to obtain the UiO-66 / BiS-DOX composite nanomaterial. The one-pot method adopted by the invention is simple in preparation process; the MOF material has the PH reactive release performance: the PH of a liver cancer tumor tissue is lower than that of a normal tissue, and an acidic tumor environment can induce the nano material to release an adriamycin drug; the photothermal conversion capacity is high, and photothermal ablation treatment can be achieved while TACE treatment is achieved.

The invention provides a tellurophene-based conjugated polymer and a synthesis method and application thereof. Inert gas protection is adopted, and organic acid, inorganic base, ligand, intermediate 1and intermediate 2 all react in organic solvent to obtain a mixture; the obtained mixture is dipped in methyl alcohol, a Soxhlet extractor is adopted to carry out Soxhlet extraction, polymer solutionobtained by the Soxhlet extraction is subjected to rotary evaporation, and solution obtained by the rotary evaporation is dipped into the methyl alcohol to obtain the tellurophene-based conjugated polymer. The conjugated polymer disclosed by the invention is prepared into nano-particles for the PDT (Photodynamics Therapy) and the PTT (Photothermal Therapy) of photoacoustic imaging guidance.

The invention provides a carbon material microbead / polymer composite film and its preparation and application. In the composite film, the carbon material microbead is a carbon nanotube microbead or a graphene microbead, and the carbon material microbead is a hierarchical hole Structure, the polymer is polyacrylic acid and its derivatives, polyvinyl alcohol, sodium alginate or chitosan, and the composite film also includes a hydrophilic film. The present invention also provides a method for preparing the composite membrane, through the microfluidic method and calcined carbon material, then mix the carbon material microbeads and the polymer aqueous solution evenly, pour it on the hydrophilic membrane after soaking, filter, exchange The carbon nanotube microbeads / polymer composite film is prepared after coupling. The method is simple to operate and environmentally friendly. The prepared composite film is used for solar-driven water evaporation, and the water evaporation rate can reach 1.62kg / m 2 / h.

The invention discloses a degradable anti-tumor nano-medicine based on limotherapy, as well as a preparation method and application thereof, and belongs to the technical field of nano-medicines. The preparation method comprises the following steps: dissolving dopamine hydrochloride in a Tris-HCl buffer solution, adding glucose oxidase into the mixture, and performing quick stirring; filtering themixture through a 0.45[mu]m water filter membrane, continuing to quickly stir the solution after filtering, and filtering the mixture through the 0.45[mu]m water filter membrane; centrifuging the secondary filtered liquid with a silver cubic solution prepared isometrically, performing precipitating and mixing, performing ultrasonic and standing treatment on the mixed solution, and performing centrifuging to obtain precipitation; resuspending the precipitation in a PBS buffer solution to obtain a glucose oxidase-loaded silver nano-cube. The particle glucose oxidase has a loading capacity of 10-25 percent and an average particle size of 100-150nm, is acidic in a tumor part and can be degraded in a hydrogen peroxide environment, and can achieve the EPR effect and a quick internal cleaning function; and an excellent tumor treatment effect is showed by combining the limotherapy of consuming glucose in the tumor part by the glucose oxidase and a photothermal therapy of the nano-silver cube.

The invention discloses a platinum-based single-atom nanozyme for combined tumor therapy and a preparation method thereof. Using cisplatin and 3,4-diaminopyridine as precursors, a platinum (IV)-based enzyme is prepared by oxidative polymerization reaction. Single-atom nanozyme drugs. Compared with the prior art, the platinum (IV)-based single-atom nano-enzyme drug prepared by the present invention has both catalase-like and peroxidase-like activities, which can greatly relieve tumor hypoxia and consume excess energy in tumors. The expressed glutathione can also promote the generation of free radicals in tumor cells, reduce toxic and side effects, and improve the therapeutic effect of radiotherapy. In addition, the nanozyme has strong absorption in the entire near-infrared region. As a photothermal conversion agent, it can absorb 808nm laser light and convert it into high-energy heat, which greatly improves the killing power to tumor cells and realizes photothermal therapy. Therefore, platinum (IV) )-based single-atom nanozyme drugs have a strong killing effect on tumor cells due to their synergistic effects of hyperthermia and radiotherapy.

The embodiment of the invention relates to the field of phase change materials, in particular to a magnetic highly-graphitized carbon-based photo-thermal composite phase change material and application thereof. Comprising magnetic highly-graphitized porous carbon and a phase change material adsorbed on the surface and / or in pores of the magnetic highly-graphitized porous carbon, the magnetic highly-graphitized porous carbon is a carbon material which is obtained by high-temperature carbonization of a metal organic framework and is highly uniformly dispersed and distributed with magnetic particles, and the magnetic particles are selected from one or more of iron, nickel and cobalt magnetic particles. And the magnetic particles account for 20-50% of the total weight of the magnetic highly-graphitized porous carbon. The magnetic graphitized carbon is used as a base material for packaging the phase change material, the graphitization degree of the magnetic graphitized carbon is high, the photothermal conversion capacity of the composite phase change material can be further improved through the surface plasma resonance (SPR) effect of the ultrahigh-dispersion magnetic particles, and the ultrahigh-dispersion magnetic particles can also be used as heat conduction nodes and heterogeneous nucleation sites to improve the photothermal conversion capacity of the composite phase change material. The heat conduction of the material is improved; and the crystallization capacity of the phase-change material in a three-dimensional carbon carrier structure is adjusted.