34results about How to "Strong light-to-heat conversion ability" patented technology

The invention discloses a multi-intelligence responsiveness microcapsule. The multi-intelligence responsiveness microcapsule is prepared from aliphatic polyamine polyurethane and ferroferric oxide, wherein each of the aliphatic polyamine polyurethane and the ferroferric oxide is of a laminated structure and a plurality of layers of the aliphatic polyamine polyurethane and the ferroferric oxide arearranged; the aliphatic polyamine polyurethane layers and the ferroferric oxide layers are alternately assembled together layer by layer to form the aliphatic polyamine polyurethane/ferroferric oxideintelligence response hollow microcapsule; the surface of the microcapsule is modified by an anti-tumor hydrophilic drug. The invention further discloses application of the microcapsule serving as acarrier for delayed release of the drug, and a preparation method of the microcapsule. The multi-intelligence response microcapsule is prepared by utilizing a layer-to-layer self-assembling method; the method is simple and convenient and low cost; the multi-intelligence response type microcapsule has excellent multi-response performance including pH (Potential of Hydrogen), temperature, near infrared, magnetic response and the like and good biocompatibility; a cancer treatment drug doxorubicin hydrochloride is modified on the surface of the microcapsule so that the target property and the utilization rate of the drug are enhanced; the multi-intelligence responsiveness microcapsule has a good application prospect in the field of controlled release of the multi-intelligence response drugs.

The invention discloses a polylactic acid-based photo-thermal film and a preparation method thereof. The method comprises the following steps: dissolving polylactic acid and polylactic acid modified lignin in a volatile organic solvent according to a certain mass ratio, preparing a matrix film from the obtained mixed solution by using an electrostatic spinning technology, and then spraying a polydopamine modified alum disulfide solution on the two sides of the matrix membrane by using a spraying technology. The photo-thermal thin film obtained through the method has thermal stability and more excellent photo-thermal conversion capacity, and the application range of the photo-thermal thin film in the solar interface evaporation field and the thermoelectric conversion field is widened.

The invention relates to a preparation method of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals. The preparation method comprises the following steps:(1) preparing a CNC solution from plant raw materials by using an acid hydrolysis method; (2) introducing iron ions with different valence states into the CNC solution, and synthesizing magnetic nanoparticles in situ under an alkaline condition to obtain a colloidal solution; and (3) adding a polymer monomer, an initiator, a cross-linking agent and a catalyst into the colloidal solution obtained in the step (2), and reacting to obtain the target product. Compared with the prior art, the CNC solution is taken as a raw material, in-situ growth of the magnetic nanoparticles is taken as a basis, and different types of polymers with different contents are added, so that preparation of photo-thermal response drug-loaded hydrogel and light-operated drug release can be realized.

The invention discloses a nanofiber for treating a bacterial infection diabetes wound surfaceand a preparation method and application thereof. The nano-fiber comprises a core curcumin nano-crystal and a shell polydopamine nano-tube. The used natural product curcumin has good biological safety, can induce M2 type polarization of macrophages, and further promotes wound healing. The polydopamine material has the advantages of excellent biocompatibility, good near-infrared conversion performance, remarkable photo-thermal antibacterial effect and the like. The nanofiber is simple in preparation process, low in cost, good in repeatability and suitable for large-scale production. The prepared nanofiber has good antibacterial and diabetes wound repair promoting capabilities, and has very high clinical application value.

The invention relates to a preparation method of a flexible fluoride-free super-hydrophobic coating with photothermal conversion and heat storage functions. According to the method, polydimethylsiloxane is introduced as an adhesive, the adhesive and a phase change material are dissolved in a solvent, then carbon-doped mesoporous silica nanotubes are dispersed in the system, and finally a blended solution is sprayed on a substrate in a spraying manner, so that the flexible fluorine-free super-hydrophobic coating with photothermal conversion and heat storage functions is obtained. The process of preparing a composite phase change material and hydrophobic modification is omitted, and the coating not only has excellent photothermal conversion capacity, but also has good flexibility and excellent super-hydrophobic performance, is simple to construct and low in preparation cost, and has huge practical application value.

The invention discloses a degradable anti-tumor nano-medicine based on limotherapy, as well as a preparation method and application thereof, and belongs to the technical field of nano-medicines. The preparation method comprises the following steps: dissolving dopamine hydrochloride in a Tris-HCl buffer solution, adding glucose oxidase into the mixture, and performing quick stirring; filtering themixture through a 0.45[mu]m water filter membrane, continuing to quickly stir the solution after filtering, and filtering the mixture through the 0.45[mu]m water filter membrane; centrifuging the secondary filtered liquid with a silver cubic solution prepared isometrically, performing precipitating and mixing, performing ultrasonic and standing treatment on the mixed solution, and performing centrifuging to obtain precipitation; resuspending the precipitation in a PBS buffer solution to obtain a glucose oxidase-loaded silver nano-cube. The particle glucose oxidase has a loading capacity of 10-25 percent and an average particle size of 100-150nm, is acidic in a tumor part and can be degraded in a hydrogen peroxide environment, and can achieve the EPR effect and a quick internal cleaning function; and an excellent tumor treatment effect is showed by combining the limotherapy of consuming glucose in the tumor part by the glucose oxidase and a photothermal therapy of the nano-silver cube.

The invention discloses a platinum-based monatomic nano-enzyme for combined treatment of tumors and a preparation method thereof, cis-platinum and 3, 4-diaminopyridine are used as precursors, and a platinum (IV)-based monatomic nano-enzyme drug is prepared through oxidative polymerization reaction. Compared with the prior art, the platinum (IV)-based monatomic nano-enzyme medicine prepared by the invention has both catalase-like and peroxidase-like activities, can relieve hypoxia of tumors to a great extent, consumes over-expressed glutathione in the tumors, and can promote generation of free radicals in tumor cells, reduce toxic and side effects and improve the radiotherapy treatment effect. The nano-enzyme has strong absorption in the whole near-infrared region, and can absorb 808nm laser and convert the laser into high-energy heat as a photothermal conversion agent, so that the lethality to tumor cells is greatly improved, and photothermal therapy is realized, and therefore, the thermotherapy and radiotherapy functions of the platinum (IV)-based monatomic nano-enzyme drug synergistically have a relatively strong killing effect on the tumor cells.

The invention provides cell-penetrating peptide modified drug-loaded thermosensitive nanoparticles and application thereof in resisting melanoma, and belongs to the technical field of nano biomedicine. According to the cell-penetrating peptide modified drug-loaded thermosensitive nanoparticles, TSL is used as a carrier, and under the modification of cell-penetrating peptide TAT, the chemotherapy effect of TMZ and the PTT treatment effect of IR820 are combined to construct a novel thermosensitive nanoparticle TAT-TSL-IR820-TMZ with a synergistic anti-tumor effect, so that targeted delivery of treatment components is realized. In-vitro experiments show that the nanoparticles can be massively taken by melanoma cells, can target lysosome, and can play a role in combined chemotherapy and photothermal action in combination with NIR.

The invention provides a drug-loaded nano-particle for hepatic artery chemoembolization. The drug-loaded nano-particle is a novel doxorubicin-loaded metal organic framework (MOF) nano-particle; and a UiO-66/Bi2S3 nano-composite, and a preparation method thereof. The preparation method of the drug-loaded nanoparticles comprises the following steps: mixing UiO-66/BiS with a DOX solution, stirring overnight in a dark environment at room temperature, centrifuging, and washing with deionized water to obtain the UiO-66/BiS-DOX composite nanomaterial. The one-pot method adopted by the invention is simple in preparation process; the MOF material has the PH reactive release performance: the PH of a liver cancer tumor tissue is lower than that of a normal tissue, and an acidic tumor environment can induce the nano material to release an adriamycin drug; the photothermal conversion capacity is high, and photothermal ablation treatment can be achieved while TACE treatment is achieved.

The invention provides a tellurophene-based conjugated polymer and a synthesis method and application thereof. Inert gas protection is adopted, and organic acid, inorganic base, ligand, intermediate 1and intermediate 2 all react in organic solvent to obtain a mixture; the obtained mixture is dipped in methyl alcohol, a Soxhlet extractor is adopted to carry out Soxhlet extraction, polymer solutionobtained by the Soxhlet extraction is subjected to rotary evaporation, and solution obtained by the rotary evaporation is dipped into the methyl alcohol to obtain the tellurophene-based conjugated polymer. The conjugated polymer disclosed by the invention is prepared into nano-particles for the PDT (Photodynamics Therapy) and the PTT (Photothermal Therapy) of photoacoustic imaging guidance.