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A platinum-based single-atom nanozyme for combined tumor therapy and preparation method thereof

A nano-enzyme and atomic technology, applied in the field of nano-materials, can solve the problems of single photothermal effect and the inability to realize the effect of dual-enzyme active radiotherapy, etc., and achieve good photothermal conversion ability, excellent OH generation ability, and excellent water dispersibility.

Active Publication Date: 2022-08-09
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing technology is that divalent platinum (II) base and 3,4-diaminopyridine are used as precursors to prepare a new type of platinum (II)-based polypyridine nano-drug (Pt(II)-PDAP), which The main effect is that the new nano-medicine has a strong absorption in the near-infrared region. The nano-medicine has good photothermal conversion efficiency and photostability through infrared thermal imager monitoring. Therefore, it can be used as a photothermal absorption reagent in bacterial light. However, the polypyridine nanomedicine of platinum (II) (Pt(II)-PDAP) only has a single photothermal effect, and cannot achieve the radiotherapy effect of dual enzyme activity

Method used

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  • A platinum-based single-atom nanozyme for combined tumor therapy and preparation method thereof
  • A platinum-based single-atom nanozyme for combined tumor therapy and preparation method thereof
  • A platinum-based single-atom nanozyme for combined tumor therapy and preparation method thereof

Examples

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Effect test

Embodiment 1

[0047] Example 1: Preparation of platinum-based single-atom nanozymes

[0048] (1) 0.2 g of cisplatin (cis-[PtCl 2 (NH 3 ) 2 ]) and 7 mL of 30% hydrogen peroxide (H 2 O 2 ) was added to a round-bottomed flask containing 5 mL of ultrapure water, the round-bottomed flask was placed in a constant temperature water bath, the rotating speed was 600 r / min, and stirred for 1 hour at 50°C to obtain a yellow solution, and the resulting solution was reconstituted in turn. After crystallization, suction filtration, washing and drying, powder A was obtained;

[0049] (2) Weigh 0.2g of powder A and dissolve it in 5mL of HCl (10M), place it in a constant temperature water bath, stir at a rotating speed of 400r / min, stir at 50°C for 1 hour, then place it at room temperature and stir overnight to obtain a yellow-green solution II;

[0050] (3) 25mL ultrapure water was added to the yellow-green solution II, then 20mmol of 3,4-diaminopyridine (0.13g) was weighed and added, the yellow-gree...

Embodiment 2

[0053] Example 2: Preparation of platinum-based single-atom nanozymes

[0054] (1) 0.4 g of cisplatin (cis-[PtCl 2 (NH 3 ) 2 ]) and 14 mL of 30% hydrogen peroxide (H 2 O 2 ) was added to a round-bottomed flask containing 10 mL of ultrapure water, the round-bottomed flask was placed in a constant temperature water bath, the rotating speed was 800 r / min, and stirred for 1 hour at 60 °C to obtain a yellow solution, and the resulting solution was reconstituted in turn. After crystallization, suction filtration, washing and drying, powder A was obtained;

[0055] (2) Weigh 0.2g of powder A and dissolve it in 5mL of HCl (10M), place it in a constant temperature water bath, stir at 600r / min at a rotational speed of 600r / min, stir at 50°C for 1 hour, then place at room temperature and stir overnight to obtain a yellow-green solution II;

[0056] (3) 25mL of ultrapure water was added to the yellow-green solution II, then 20mmol of 3,4-diaminopyridine (0.13g) was weighed and added...

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Abstract

The invention discloses a platinum-based single-atom nanozyme for combined tumor therapy and a preparation method thereof. Using cisplatin and 3,4-diaminopyridine as precursors, a platinum (IV)-based enzyme is prepared by oxidative polymerization reaction. Single-atom nanozyme drugs. Compared with the prior art, the platinum (IV)-based single-atom nano-enzyme drug prepared by the present invention has both catalase-like and peroxidase-like activities, which can greatly relieve tumor hypoxia and consume excess energy in tumors. The expressed glutathione can also promote the generation of free radicals in tumor cells, reduce toxic and side effects, and improve the therapeutic effect of radiotherapy. In addition, the nanozyme has strong absorption in the entire near-infrared region. As a photothermal conversion agent, it can absorb 808nm laser light and convert it into high-energy heat, which greatly improves the killing power to tumor cells and realizes photothermal therapy. Therefore, platinum (IV) )-based single-atom nanozyme drugs have a strong killing effect on tumor cells due to their synergistic effects of hyperthermia and radiotherapy.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a platinum-based single-atom nanozyme for combined tumor therapy and a preparation method thereof. Background technique [0002] Cancer, as a disease with high mortality and incurable, has always caused extreme distress to people's lives. According to the 2015 World Cancer Report data, global cancer cases have been growing rapidly. In the past 20 years, the incidence of cancer in my country has shown a trend of younger age, higher morbidity and mortality, and there are as many as 270 cases of cancer deaths in the country every year. Thousands of cases. The current treatments for cancer mainly include surgery, radiation therapy and chemotherapy. However, due to the large side effects of these treatment methods and easy to lead to adverse consequences, it is difficult to meet the clinical needs. Therefore, in order to effectively treat cancer, people have begun ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/243A61K9/14A61P35/00
CPCA61K41/0052A61K33/243A61K9/14A61P35/00A61K2300/00
Inventor 雍媛徐琦琦张月通
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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