A degradable anti-tumor nano drug based on starvation therapy and its preparation method and application
A nano-drug, starvation therapy technology, applied in anti-tumor drugs, biochemical equipment and methods, drug combinations, etc., can solve the problems of affecting the therapeutic effect, tumor accumulation and poor retention, etc., to speed up metabolism in vivo, strong photothermal conversion Ability, simple effect of preparation method
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Embodiment 1
[0038] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare octreotide acetate hydrochloric acid solution with a concentration of 0.3mM and a pH value of 1, and prepare AgNO with a concentration of 0.9mM respectively. 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 3%, they were mixed with a volume ratio of 1:1, ultrasonic treatment was performed for 30s, and ultrasonic power was 90W. A silver colloid solution was obtained. Configure AgNO at a concentration of 7mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution at a volume ratio of 1:1:3, placed in a digital display double-layer air bath constant temperature oscillator, at 200rpm, 20 Incubate at ℃ for 20 h. Prepare NaBH with a concentration of 80mM ...
Embodiment 2
[0042] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare octreotide acetate hydrochloric acid solution with a concentration of 0.3mM and a pH value of 1, and prepare AgNO with a concentration of 0.9mM respectively. 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 3%, they were mixed with a volume ratio of 1:1, ultrasonic treatment was performed for 30s, and ultrasonic power was 90W. A silver colloid solution was obtained. Configure AgNO at a concentration of 7mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution in a volume ratio of 1:1:3, placed in a digital display double-layer air bath constant temperature oscillator, at 200rpm, 20 Incubate at ℃ for 20 h. Prepare NaBH with a concentration of 80mM ...
Embodiment 3
[0046] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare octreotide acetate hydrochloric acid solution with a concentration of 0.3mM and a pH value of 1, and prepare AgNO with a concentration of 0.9mM respectively. 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 3%, they were mixed with a volume ratio of 1:1, ultrasonic treatment was performed for 30s, and ultrasonic power was 90W. A silver colloid solution was obtained. Configure AgNO at a concentration of 7mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution in a volume ratio of 1:1:3, placed in a digital display double-layer air bath constant temperature oscillator, at 200rpm, 20 Incubate at ℃ for 20 h. Prepare NaBH with a concentration of 80mM ...
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