Nanofiber for treating bacterial infection diabetes wound and preparation method and application thereof

A nanofiber and bacterial infection technology, which is applied in the direction of antibacterial drugs, medical preparations containing active ingredients, metabolic diseases, etc., to achieve low production costs, good biocompatibility, and good reproducibility
CN113197839APending Publication Date: 2021-08-03YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2021-08-03

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Abstract

The invention discloses a nanofiber for treating a bacterial infection diabetes wound surfaceand a preparation method and application thereof. The nano-fiber comprises a core curcumin nano-crystal and a shell polydopamine nano-tube. The used natural product curcumin has good biological safety, can induce M2 type polarization of macrophages, and further promotes wound healing. The polydopamine material has the advantages of excellent biocompatibility, good near-infrared conversion performance, remarkable photo-thermal antibacterial effect and the like. The nanofiber is simple in preparation process, low in cost, good in repeatability and suitable for large-scale production. The prepared nanofiber has good antibacterial and diabetes wound repair promoting capabilities, and has very high clinical application value.
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Description

technical field

[0001] The invention relates to a nanofiber for treating bacterial infection of diabetic wounds, a preparation method and application thereof, and belongs to the field of pharmaceutical preparations and the technical field of biomedicine. Background technique

[0002] The wounds of diabetic patients are difficult to heal, and they have high morbidity and mortality worldwide. The restoration of skin integrity, homeostasis and protective function after injury is crucial to the quality of life and survival. The hindered healing of diabetic wounds is often accompanied by bacterial infection, which will not only aggravate wound deterioration, delay healing, and even lead to sepsis and eventually death. Currently, active ingredients such as antibiotics, anti-inflammatory drugs, exosomes, growth factors, etc. provide feasible options for fighting bacterial infections, inhibiting inflammatory responses, and accelerating wound healing. However, the above-mentioned th...

Claims

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