Drug-loaded nano-particles for hepatic artery chemoembolization and preparation method of drug-loaded nano-particles

A technology of drug-loaded nanoparticles and nanoparticles, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, and medical preparations containing active ingredients. Limited and high process complexity, to achieve the effect of photothermal ablation, strong photothermal conversion ability, and simple preparation process

Pending Publication Date: 2022-06-07
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to limited material properties, the existing DEB drug-loaded microspheres do not have pH-responsive release and light-to-heat conversion capabilities. For example, Chinese patent document CN109789226A discloses a composition for hepatic artery embolization, which is characterized in that it contains: embolization substances; and human serum albumin nanoparticles carrying a water-soluble anticancer agent; a step of dispersing the human serum albumin nanoparticles carrying a water-soluble anticancer agent into computed tomography and X-ray contrast agents; the dispersed nano The step of mixing particles with microbubbles; and the step of mixing the mixture of nanoparticles and microbubbles with embolic substances; the drug-loaded nanoparticles given in this document are different from the product technology of the present invention, and the products prepared at the same time have pH reactivity The release and light-to-heat conversion capabilities are not very high, and the process complexity is high

Method used

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  • Drug-loaded nano-particles for hepatic artery chemoembolization and preparation method of drug-loaded nano-particles
  • Drug-loaded nano-particles for hepatic artery chemoembolization and preparation method of drug-loaded nano-particles
  • Drug-loaded nano-particles for hepatic artery chemoembolization and preparation method of drug-loaded nano-particles

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Experimental program
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preparation example Construction

[0028] The preparation method of a drug-loaded nanoparticle of the present embodiment includes the following steps:

[0029] Step 1: Dissolve 0.0772 g of bismuth acetate (Bi(CHO)) in 30 mL of ethylene glycol to form a homogeneous solution, 0.175 g of UiO-66-NH sample is dissolved in 5 mL of ethylene glycol, and ultrasonically stir for 25-35 min. Stir slowly at room temperature in bismuth acetate for 55-65min;

[0030] Step 2: Add the NaS solution dropwise, continue to stir for 25-35min, then transfer the suspension to a stainless steel hydrothermal kettle, stand at 85-95°C for 0.8-1.2 hours, wash by centrifugation, ethanol and deionized water, And dried in an oven at 80 °C for 24 hours to obtain UiO-66 / BiS;

[0031] Step 3: Mix the prepared UiO-66 / BiS and DOX solution, stir overnight at room temperature in a dark environment, and obtain UiO-66 / BiS@DOX composite nanomaterials after centrifugation and washing with deionized water.

[0032] The addition amount of the NaS soluti...

Embodiment 1

[0039] In this embodiment,

[0040] A drug-loaded nanoparticle for hepatic arterial chemoembolization in this embodiment is a novel doxorubicin-loaded metal-organic framework (MOF) nanoparticle; and a UiO-66 / Bi2S3 nanocomposite.

[0041] The preparation method of a drug-loaded nanoparticle of the present embodiment includes the following steps:

[0042] Step 1: Dissolve 0.0772 g of bismuth acetate (Bi(CHO)) in 30 mL of ethylene glycol to form a homogeneous solution, and dissolve 0.175 g of UiO-66-NH sample in 5 mL of ethylene glycol with ultrasonic stirring for 25 min, and then add it to bismuth acetate. Stir slowly at room temperature for 55min;

[0043] Step 2: Add the NaS solution dropwise, continue stirring for 25 min, then transfer the suspension to a stainless steel hydrothermal kettle, stand at 85°C for 0.8 hours, wash by centrifugation, ethanol and deionized water, and store in an oven at 80°C Dry for 24 hours to obtain UiO-66 / BiS;

[0044] Step 3: Mix the prepared ...

Embodiment 2

[0050] In this embodiment,

[0051]A drug-loaded nanoparticle for hepatic arterial chemoembolization in this embodiment is a novel doxorubicin-loaded metal-organic framework (MOF) nanoparticle; and a UiO-66 / Bi2S3 nanocomposite.

[0052] The preparation method of a drug-loaded nanoparticle of the present embodiment includes the following steps:

[0053] Step 1: Dissolve 0.0772 g of bismuth acetate (Bi(CHO)) in 30 mL of ethylene glycol to form a homogeneous solution, and dissolve 0.175 g of UiO-66-NH sample in 5 mL of ethylene glycol with ultrasonic stirring for 35 min, and then add it to bismuth acetate. Stir slowly at room temperature for 65 min;

[0054] Step 2: Add the NaS solution dropwise, continue stirring for 35 min, then transfer the suspension to a stainless steel hydrothermal kettle, stand at 95°C for 1.2 hours, wash by centrifugation, ethanol and deionized water, and store in an oven at 80°C Dry for 24 hours to obtain UiO-66 / BiS;

[0055] Step 3: Mix the prepared ...

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Abstract

The invention provides a drug-loaded nano-particle for hepatic artery chemoembolization. The drug-loaded nano-particle is a novel doxorubicin-loaded metal organic framework (MOF) nano-particle; and a UiO-66 / Bi2S3 nano-composite, and a preparation method thereof. The preparation method of the drug-loaded nanoparticles comprises the following steps: mixing UiO-66 / BiS with a DOX solution, stirring overnight in a dark environment at room temperature, centrifuging, and washing with deionized water to obtain the UiO-66 / BiS-DOX composite nanomaterial. The one-pot method adopted by the invention is simple in preparation process; the MOF material has the PH reactive release performance: the PH of a liver cancer tumor tissue is lower than that of a normal tissue, and an acidic tumor environment can induce the nano material to release an adriamycin drug; the photothermal conversion capacity is high, and photothermal ablation treatment can be achieved while TACE treatment is achieved.

Description

technical field [0001] The invention relates to the technical field of hepatic arterial chemoembolization, in particular to a drug-loaded nanoparticle for hepatic arterial chemoembolization and a preparation method thereof. Background technique [0002] Drug-eluting microsphere embolization (DEB-TACE) is currently used in clinical TACE treatment. "Drug-eluting microsphere" is a new type of embolic material that can adsorb and carry chemotherapeutic drugs. It is not degradable in the body, and it enters the tumor. On the one hand, the blood vessel can embolize the tumor blood vessels for a long time, and on the other hand, it can make the chemotherapy drugs act on the tumor for a long time. The two effects are superimposed, which can achieve better local control effect. [0003] Due to the limited material properties of the existing DEB drug-loaded microspheres, they do not have pH reactive release and photothermal conversion capabilities. For example, Chinese patent document...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/69A61P35/00
CPCA61K41/0052A61K31/704A61K47/6949A61K47/6935A61P35/00A61K2300/00A61L24/0015A61L24/0068A61L2400/12A61L2430/36A61K9/5146A61K47/6929A61K47/6923A61L2300/232
Inventor 李家平刘玲尉
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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