A core-shell gold nanoparticle with enhanced light-to-heat conversion effect

A gold nanoparticle, core-shell gold technology, applied in the pharmaceutical field, can solve the problems of low stability, difficult to control, wide distribution, etc., and achieve the effects of small particle size, small size, and simple operation

Active Publication Date: 2017-07-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nanocarriers prepared by the above method have larger particle size, wider distribution, are difficult to control, and have low stability.

Method used

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  • A core-shell gold nanoparticle with enhanced light-to-heat conversion effect
  • A core-shell gold nanoparticle with enhanced light-to-heat conversion effect
  • A core-shell gold nanoparticle with enhanced light-to-heat conversion effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The composition of the new core-shell gold nanometer:

[0065] Doxorubicin hydrochloride (DOX·HCl) solution (10mg / mL) 500µL

[0066] Cobalt Chloride Hydrate (CoCl 2 •6H 2 O) solution (0.04 mol / L) 2mL

[0067] Sodium borohydride (NaBH 4 ) 35.7mg

[0068] Polyvinylpyrrolidone (PVP-12) (0.05g / mL) 4mL

[0069] Chloroauric acid hydrate (HAuCl 4 4H 2 O) solution (0.1mol / L) 200µL

[0070] At 30°C, add the prescribed amount of PVP-12 to a three-neck flask containing 100ml of ultrapure water, and add CoCl under the protection of argon. 2 •6H 2 O and NaBH 4 , reacted for 30min, and added the prescribed amount of HAuCl to 200mL ultrapure water 4 4H 2 O, mixed with the above reaction solution, and continued to react for about 1h under the protection of argon. Add the prescribed amount of doxorubicin hydrochloride solution, avoid light and seal the reaction for 24 hours. The novel core-shell gold nanoparticles loaded with doxorubicin are obtained after low-temperature ...

Embodiment 2

[0108] The composition of the new core-shell gold nanometer:

[0109] Doxorubicin hydrochloride (DOX·HCl) solution (10mg / mL) 500µL

[0110] Cobalt Chloride Hydrate (CoCl 2 •6H 2 O) solution (0.04 mol / L) 2mL

[0111] Sodium borohydride (NaBH 4 ) 35.7mg

[0112] Polyvinylpyrrolidone (PVP-12) (0.05g / mL) 4mL

[0113] Chloroauric acid hydrate (HAuCl 4 4H 2 O) solution (0.1mol / L) 200µL

[0114] At 10°C, add the prescribed amount of PVP-12 to a three-neck flask containing 100ml of ultrapure water, and add CoCl under the protection of argon. 2 •6H 2 O and NaBH 4 , reacted for 30min, and added the prescribed amount of HAuCl to 200mL ultrapure water 4 4H 2 O, mixed with the above reaction solution, and continued to react for about 1h under the protection of argon. Add the prescribed amount of doxorubicin hydrochloride solution, avoid light and seal the reaction for 24 hours. The novel core-shell gold nanoparticles loaded with doxorubicin are obtained after low-temperature ...

Embodiment 3

[0116] The composition of the new core-shell gold nanometer:

[0117] Doxorubicin hydrochloride (DOX·HCl) solution (10mg / mL) 500µL

[0118] Cobalt Chloride Hydrate (CoCl 2 •6H 2 O) solution (0.04 mol / L) 2mL

[0119] Sodium borohydride (NaBH 4 ) 35.7mg

[0120] Polyvinylpyrrolidone (PVP-12) (0.05g / mL) 4mL

[0121] Chloroauric acid hydrate (HAuCl 4 4H 2 O) solution (0.1mol / L) 200µL

[0122] At 70°C, add the prescribed amount of PVP-12 to a three-necked flask containing 100ml of ultrapure water, and add CoCl under the protection of argon. 2 •6H 2 O and NaBH 4 , reacted for 30min, and added the prescribed amount of HAuCl to 200mL ultrapure water 4 4H 2 O, mixed with the above reaction solution, and continued to react for about 1h under the protection of argon. Add the prescribed amount of doxorubicin hydrochloride solution, avoid light and seal the reaction for 24 hours. The novel core-shell gold nanoparticles loaded with doxorubicin are obtained after low-temperatur...

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Abstract

The invention provides a core-shell gold nano-particle capable of intensifying the photo-thermal transformation effect. The novel core-shell structure gold nano-particle is composed by using gold as a shell and medicines as a core and loading acid radical medicines in the hollow structure of the hollow gold nano-particle, and is absorbed by a characteristic peak in a near infrared region with the wavelength of 700-900nm, wherein the particle diameter is 30-200nm. In the photo-thermal action, the structure of the gold nano-particle becomes loose to trigger release of medicines and play the effect of chemotherapy. The core-shell gold nano-particle shows an intensified photo-thermal transformation capability under near infrared light (wavelength of 700-900nm) radiation to generate a thermal-therapy effect on a tumor site, and can generate double effects of thermal therapy and chemo therapy; and the two treatment modes synergetically act, and are conductive to killing tumor cells comprehensively and completely. The core-shell gold nano-particle is capable of remarkably improving the effect for treating tumors, and can be applied to preparation of tumor treatment medicaments.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a core-shell gold nanoparticle with enhanced photothermal conversion effect, which is a new type of gold nanometer drug delivery system loaded with drugs, and relates to a preparation method of the gold nanoparticle and combined with near-infrared light irradiation. tumor applications. Background technique [0002] Tumor hyperthermia has become the fifth major therapy after surgery, chemotherapy, radiotherapy, and immunotherapy, and it is a new and effective way to treat tumors. Its basic principle is to use physical energy to heat the whole body or part of the human body, so that the temperature of tumor tissue rises to the effective therapeutic temperature and maintain it for a certain period of time, and utilizes the difference in temperature tolerance between normal tissue and tumor cells to achieve both inhibition of tumor cell growth and without damaging normal tissues. [0003] The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/02A61K9/51A61P35/00
Inventor 游剑周佳林胡富强杜永忠袁弘
Owner ZHEJIANG UNIV
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