The invention relates to medical healthcare equipment, in particular to a wearable multi-field radiation whole-body hyperthermia device. Heat is introduced into a radiating target (i.e., a great vessel) by means of probe beams, and the energy of ultrasound, infrared, laser, microwave, radio frequency and electromagnetic probes at each frequency range is introduced into a vascular circulation system through the radiation probe network composed of probe beams distributed on an attachment in the form of optimum biological heat absorption, and then heat is transferred throughout the body through a hemoperfusion method, so that the vivo tissue is rapidly heated through conduction of biological heat in the tissue. The device has the characteristics of high thermal utilization ratio, high blood flow rate and high specific heat, and thermal convection is rapidly conducted between the radiant heat and the tissue to realize whole-body hyperthermia, therefore, the device not only can realize the purposes of uniformity of the machine body and rapid temperature rise, but also avoid the phenomenon of local overheating, simultaneously, has the accessibility of a wearable device and is a high-efficiency hyperthermia equipment without ache.