Drug carrier, preparation method thereof, pharmaceutical composition made from drug carrier, and applications of drug carrier and pharmaceutical composition

The technology of a composition and a drug is applied to a drug carrier and its preparation, a drug composition and its application field, which can solve the problems of large drug loading, and the gold nanorods are not easy to carry drugs, and can achieve a large drug loading and prevent agglomeration. Effect

Inactive Publication Date: 2014-07-02
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the problem that gold nanorods are not easy to carry drugs in the prior art, and provide a novel drug carrier and a preparation method thereof. The novel drug carrier contains gold nanorods and has a large drug loading capacity

Method used

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  • Drug carrier, preparation method thereof, pharmaceutical composition made from drug carrier, and applications of drug carrier and pharmaceutical composition
  • Drug carrier, preparation method thereof, pharmaceutical composition made from drug carrier, and applications of drug carrier and pharmaceutical composition
  • Drug carrier, preparation method thereof, pharmaceutical composition made from drug carrier, and applications of drug carrier and pharmaceutical composition

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preparation example Construction

[0043] The present invention also provides a method for preparing a drug carrier, wherein the method includes the following steps: in a gold nanorod solution containing cetyltrimethylammonium bromide, under the condition of pH 8.5-11 , add alcohol solution of silicate to react, and carry out solid-liquid separation to obtain gold nanorods coated with mesoporous silicon dioxide layer on the surface.

[0044] According to the preparation method of the drug carrier of the present invention, the method for preparing the aqueous solution of gold nanorods can be carried out by conventional methods in the art. For example, it can be prepared by seed growth method. The steps are to reduce chloroauric acid with sodium borohydride in the presence of cetyltrimethylammonium bromide to obtain a seed solution of gold nanoparticles. In the presence of methyl ammonium bromide, the seed solution is added to the monovalent gold ion solution obtained by reducing chloroauric acid with ascorbic ac...

Embodiment 1

[0077] This example is used to illustrate the preparation of the pharmaceutical composition.

[0078] 1) Preparation of drug carrier

[0079] In a 20 ml beaker, mix 7.5 ml of cetyltrimethylammonium bromide aqueous solution with a concentration of 0.1 mol / L and 250 microliters of chloroauric acid aqueous solution (with a concentration of 0.01 mol / L), add water to The total volume was 9.4 ml; then 0.6 ml of sodium borohydride aqueous solution (concentration: 0.01 mol / L) cooled by ice water was added; stirred at 25° C. for 3 hours to obtain a gold nanoparticle seed solution.

[0080] In a 150 ml flask, add 100 ml of cetyltrimethylammonium bromide (concentration: 0.1 mol / L), 5 ml of chloroauric acid aqueous solution (concentration: 0.01 mol / L), 0.8 ml of nitric acid Silver aqueous solution (concentration: 0.01 mol / liter), 2 ml of sulfuric acid aqueous solution (concentration: 0.5 mol / liter), and 800 microliters of ascorbic acid aqueous solution (concentration: 0.1 mol / liter); the...

Embodiment 2

[0088] This example is used to illustrate the preparation of the pharmaceutical composition.

[0089] 1) Preparation of drug carrier

[0090] In a 20 ml beaker, mix 7.5 ml of cetyltrimethylammonium bromide aqueous solution (the concentration of cetyltrimethylammonium bromide is 0.1 mol / L) with 250 μl of chloroauric acid aqueous solution (concentration of 0.01 mol / liter) mixed, add water to a total volume of 9.4 ml; then add 0.6 ml of sodium borohydride aqueous solution (concentration of 0.01 mol / liter) cooled by ice water; stir at 25°C for 3 hours to obtain Gold nanoparticles seed solution.

[0091] In a 150 ml flask, add 100 ml of cetyltrimethylammonium bromide (concentration: 0.1 mol / L), 5 ml of chloroauric acid aqueous solution (concentration: 0.01 mol / L), 2 ml of nitric acid Silver aqueous solution (concentration: 0.01 mol / liter), 4 ml of sulfuric acid aqueous solution (concentration: 0.5 mol / liter), and 800 microliters of ascorbic acid aqueous solution (concentration: 0...

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Abstract

The invention discloses a drug carrier, a preparation method, a pharmaceutical composition made from the drug carrier, and applications of the drug carrier and the pharmaceutical composition. The mesoporous silica-coated gold nanorod (Au@SiO2) carrier is characterized in that: gold nanorods are coated with a layer of mesoporous silica. According to the preparation method, the Au@SiO2 carrier is prepared by taking hexadecyl trimethyl ammonium bromide-coated gold nanorods as raw materials via hydrolytic polymerization with orthosilicate ester, can be used for coating a plurality of drugs and probe molecules, and delivering the drugs and the probe molecules to parts of diseases so as to realize targeting therapy. After absorption of near-infrared laser, the Au@SiO2 carrier, or drug-loaded Au@SiO2 nanoparticles are capable of emitting fluorescence and transforming a part of light energy into heat energy, so that the Au@SiO2 carrier and the drug-loaded Au@SiO2 nanoparticles can be used for bioimaging, light-dependent control drug release (chemotherapy), and thermotherapy. The preparation method of the Au@SiO2 carrier is simple; the Au@SiO2 carrier can be used for a plurality of diagnosis and treatment methods, and the plurality of diagnosis and treatment methods can be combined, so that it is beneficial for avoiding defects of a single diagnosis and treatment method, and the drug carrier and the pharmaceutical composition are especially suitable for tumor diagnosis and treatment with complex requirements.

Description

technical field [0001] The invention relates to a drug carrier, a preparation method thereof, a drug composition and an application thereof. Specifically, it relates to a drug carrier and a preparation method thereof, a pharmaceutical composition loaded with drugs on the drug carrier, and the preparation of the drug carrier and the pharmaceutical composition for diagnosis and / or treatment of tumors application in medicine. Background technique [0002] Traditional cancer treatment methods, due to the lack of targeting of cancer tissue, exert therapeutic effects while also harming non-pathological tissues, which often have great side effects. In recent years, nanotechnology has shown unique advantages in enhancing the pharmacological activity and reducing toxicity of anticancer drugs. Macromolecules and lipid particles have high permeability and retention effects in cancerous tissue due to the characteristics of rich blood vessels, wide space between blood vessel walls, poo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/02A61P35/00
Inventor 陈春英仉振江王静王黎明吴晓春
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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