Prostate cancer ablation

Abstract

Methods and systems for delivering electrical energy and controlled, mild hyperthermia to a prostate tissue of a patient for destruction of cancerous and/or hyperplastic tissue. A method includes positioning a plurality of electrodes in a target tissue region comprising the prostate tissue, and establishing an alternating electrical current flow through a volume of the prostate tissue to induce mild heating and destruction of cancerous cells in the volume.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Patent Application No. 60 / 972,698 (Attorney Docket No. 26533A-000700US), filed Sep. 14, 2007, the full disclosure of which is incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]The present invention relates generally to electric field delivery to a prostate tissue of a patient. More particularly, the present invention provides systems and methods for delivering alternating current and controlled, mild heating to a prostate tissue of a patient for destruction of cancerous and / or hyperplastic tissue.[0003]The prostate gland is a walnut-sized gland located in the pelvic area, just below the outlet of the bladder and in front of the rectum. It encircles the upper part of the urethra, which is the tube that empties urine from the bladder. The prostate is an important part of the male reproductive system, requiring male hormones like testosterone to fu...

AI Technical Summary

Problems solved by technology

In addition to risks of morbidity due to prostate cancer, most men over 60 years old experience partial or complete urinary obstruction due to enlargement of the prostate.

Ionizing radiation has the effect of damaging a cells DNA and limiting its ability to reproduce.

During EBRT, the rays pass through and can damage other tissue on the way to the tumor, causing side effects such as short-term bowel or bladder problems, and long-term erectile dysfunction.

Radiation therapy can also temporarily decrease energy levels and cause loss of appetite.

Once positioned in the tissue, the radiation from the seeds extends a few millimeters to deliver a higher radiation dose in a smaller area, causing non-specific damage to the surrounding tissue.

The seeds are left in place permanently, and usually lose their radioactivity within a year.

Internal radiation also causes side effects such as short-term bowel or bladder problems, and long-term erectile dysfunction.

Internal radiation therapy can also temporarily decrease energy levels

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