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Method of hyperthemia treatment

a technology of magnetic nanoparticles and hyperthemia, which is applied in the field of magnetic nanoparticle compositions, can solve the problems of affecting the clinical utility of each approach, unable to achieve the effect of generating hysteresis heat, and inability to excision,

Inactive Publication Date: 2010-04-22
FLORIDA STATE UNIV RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Each approach has limitations affecting it clinical utility.
For example, excision may not be appropriate where the disease presents as a diffuse mass or is in a surgically inoperable location.
Chemotherapeutic agents are generally non-specific, thus resulting in the death of both normal and diseased cells.
Radiotherapy is also nonspecific and results in the death of normal tissues exposed to ionizing radiation.
It has been reported that when heat and a radiosensitizing agent (e.g., misonidazole) are used in combination with each other, they produce synergistic potentiation effects.
However, Hofer's whole body heating approach is not optimal for clinical application on human, because whole-body heating limits the heat dose that can be given.
Limitations of these methods are due either to the invasive thermometry or in their inability to reach optimal temperature for the tumor sites when noninvasive techniques are used, especially in the treatment of deep-seated tumors.
However, at least two impediments to clinical implementation have been identified: (1) the lack of uniform heat distribution at the tumor site and the resultant creation of spot overheating that leads to necrosis; and (2) the size of these thermoseed particles are on the order of 1 to 5 cm, making them highly non-biocompatible.
Unfortunately, conventional magnetic particles make it impossible to control the uneven heating at the tumor site, which may cause local overheating and necrosis of healthy tissue.

Method used

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Examples

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Effect test

example 1

Physically Synthesized Nickel-Copper Nanoparticles for Magnetic Hyperthermia

[0067]Nanoparticles, which consisted of a binary alloy of copper-nickel, having a preselected Curie temperature, were made.

[0068]The phase equilibria system for copper-nickel shows a linear progression for the Curie temperature, which starts at a composition of 67% nickel and 33% copper (by weight) for a temperature of 0° C. (Chakrabarti et al., Binary alloy phase diagrams, Materials Park, Ohio, 1990 Massalski et al. (editors)). From the Cu—Ni alloy phase diagram, the optimum amount of nickel in the alloy was selected to be 71-71.4% by weight, in order to yield an alloy having a Curie temperature in the range of 41 to 46° C.

[0069]The nanoparticles were made by process that combined melting and ball milling of bulk materials. The nickel-copper alloy was obtained via physical melting, in which nickel powder (AlfaAesar, 325 mesh, 99%) and copper powder (AlfaAesar, 500 mesh, 99%) were mixed in the desired compos...

example 2

Synthesis of Nickel-Chromium (Ni1-xCrx) Nanoparticles

[0076]A series of Ni1-xCrx alloys were prepared to find the specific composition that has a Curie temperature around 316-317 K. Magnetic properties of the samples were investigated, including Curie temperature, saturation magnetization and hysteresis. The Curie temperatures of the alloys were decreased from 401 K to 289 K, while increasing the Cr concentration from x=4.54 wt % to x=5.90 wt %. The results showed that (Ni1-xCrx) alloys are good candidates for self regulating magnetic hyperthermia applications, because the Curie temperature of the alloys decreases almost linearly with increasing Cr concentration.

[0077]A series of NiCr binary alloys were prepared from nickel and chromium metals with 99.9% purity under a argon gas atmosphere by a standard arc melting technique. The samples were turned over and re-melted three times to ensure homogeneity. Finally the samples were annealed in argon gas filled and sealed quartz tubes at 8...

example 3

Gadolinium Substitution on Mn—Zn-Ferrite Nanoparticles

[0081]Mn—Zn ferrite and Gd substituted Mn—Zn ferrite nanoparticles were synthesized using a chemical co-precipitation method to obtain low Curie temperature magnetic particles with a moderately high value of magnetization and a high pyromagnetic coefficient. The magnetic properties and temperature dependence of these particles, and the effect of varying Gd proportions, were studied. The particles exhibited properties that make would make them worth considering for hyperthermia applications.

[0082]Mn—Zn-ferrite particles and Gd substituted Mn—Zn-Ferrite particles were obtained via chemical co-precipitation and ferritization. First, the metal salts were co-precipitated into hydroxides. This was done by addition of aqueous solution of metal salts in water to the coprecipitating base (e.g. NaOH, CH3NH3OH etc.). For the case of Mn—Zn Ferrite particles the reaction occurs as follows:

Then this precipitate is transformed into ferrite by h...

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PUM

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Abstract

Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. patent application Ser. No. 11 / 125,488, filed May 10, 2005, which claims the benefit of U.S. Provisional Application No. 60 / 569,726, filed May 10, 2004. The applications are incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION[0002]This invention relates generally to magnetic nanoparticle compositions, and more particularly to magnetic nanoparticle compositions useful in self-controlled hyperthermia treatment.[0003]Diseases of the human body such as malignant tumors are generally treated by excision, chemotherapy, radiotherapy or a combination of these approaches. Each approach has limitations affecting it clinical utility. For example, excision may not be appropriate where the disease presents as a diffuse mass or is in a surgically inoperable location. Chemotherapeutic agents are generally non-specific, thus resulting in the death of both normal and diseased cells. Radioth...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N2/00A61K33/243A61K33/244A61K33/26A61K33/32A61K33/34A61N1/40
CPCA61K33/24A61K33/26Y10T428/2998A61K33/34A61N1/406A61K33/32A61K33/243A61K33/244
Inventor HAIK, YOUSEFCHEN, CHING-JEN
Owner FLORIDA STATE UNIV RES FOUND INC
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