166 results about "Triggered release" patented technology

The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems generally comprise two or more separate components for targeting, imaging, sensing, and / or triggering release of a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).

A delivery device for percutaneously deploying a prosthetic valve includes a sheath, an inner shaft, and a release assembly. The release assembly is disposed between the sheath and the inner shaft, and includes a retraction member, a release member, and a retention member. The retraction member can self-retract in length from an extended condition to a retracted condition. The release member can self-expand from a compressed condition to an expanded condition. The retention member is distal the release member. In a delivery state, the sheath end is distal the retention member, the release member is in the compressed condition and the retraction member in the extended condition to retain the prosthesis. In a deployment state, the sheath end is positioned to permit the release member to self-transition to the expanded condition, allowing the retraction member to self-transition to the retracted condition and release the prosthesis.

The present invention is a controlled delivery system that can be incorporated in hair, skin, and fabric care products such as shampoos, conditioners, hair styling products, lotions, creams, liquid laundry detergents, fabric softener, and other hair, skin, and fabric care products to effectively deliver a broad range of active agents and sensory markers onto the hair, skin, and fabric. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon blow drying the hair, ironing the fabric, or other types of heat treatment. The controlled delivery system of the present invention is a nano-sphere, having an average sphere diameter of from about 0.01 microns to about 10 microns. The nano-sphere comprises hydrophobic materials, cationic conditioning agent or, cationic conditioning agent in conjunction with a cationic charge booster to assist in adhering the spheres onto hair, skin, and fabric. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.

The present invention relates to an improved controlled release system that can be incorporated into anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or different from those encapsulated in the micro-sphere. The encapsulation of one or more fragrances, flavors or active agents in the various components of the system, such as nano-spheres and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor character) during the use of the product, in response to moisture, such as wetting the lips, perspiration, and the like. The incorporation of the controlled release system of the present invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in the solid hydrophobic nano-spheres over an extended period of time.

The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems generally comprise two or more separate components for targeting, imaging, sensing, and / or triggering release of a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).

One embodiment of a trigger system with an integral selector for semi-automatic firearms. A selector allows the user to choose between two modes and rates of fire. A trigger (1) is made to allow passage of the lower portion of a selector cam (5) to the exterior of the firearm. A selector lever (6) is affixed to the lower end of the selector cam (5) on the exterior of the firearms action. Turning the selector lever (6) rotates the selector cam (5) which tilts a pivotal disconnector (3) on its axis, varying the amount of disconnector (3) engagement with a hammer (2). The variance in the disconnector (3) engagement causes the firearm to fire in one of two modes, firing one round with a trigger pull and resetting with trigger release, or firing one round with trigger pull, and firing another round with trigger release. Other embodiments are described.

The present invention relates to a novel controlled release carrier system for pH or salt triggered release and targeted delivery of fragrances and other active ingredients onto fabric, hair, skin, and other biological surfaces and which provides prolonged release of fragrances and other active ingredients over an extended period of time, or yields a high impact fragrance “burst” upon treating the target surface with heat (blow drying the hair, ironing the fabric). The controlled delivery system of the present invention is substantially a free-flowing powder formed of solid hydrophobic nano-spheres comprising the fragrance and other active ingredients that are encapsulated in a pH or salt sensitive micro-spheres. Also described are processes for preparing such compositions and processes for using same. Furthermore, certain components of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity, particularly in fabric, hair, and skin care preparations. The invention further pertains to consumer and diversified products comprising the controlled release system of the present invention.

Disclosed are methods and related compositions for altering the physical and chemical properties of a substrate used in hydrocarbon exploitation, such as in downhole drilling operations. In a preferred embodiment a method involves formulating a fluid, tailored to the specific drilling conditions, that contains one or more inactivated enzymes. Preferably the enzyme is inactivated by encapsulation in a pH responsive material. After the fluid has been introduced into the well bore, one or more triggering signals, such as a change in pH, is applied to the fluid that will activate or reactivate the inactivated enzyme, preferably by causing it to be released by the encapsulation material. The reactivated enzyme is capable of selectively acting upon a substrate located downhole to bring about the desired change in the chemical or physical properties of the substrate.

One embodiment of a trigger system with an integral selector for semi-automatic firearms. A selector allows the user to choose between two modes and rates of fire. A trigger (1) is made to allow passage of the lower portion of a selector cam (5) to the exterior of the firearm. A selector lever (6) is affixed to the lower end of the selector cam (5) on the exterior of the firearms action. Turning the selector lever (6) rotates the selector cam (5) which tilts a pivotal disconnector (3) on its axis, varying the amount of disconnector (3) engagement with a hammer (2). The variance in the disconnector (3) engagement causes the firearm to fire in one of two modes, firing one round with a trigger pull and resetting with trigger release, or firing one round with trigger pull, and firing another round with trigger release. Other embodiments are described.

The present invention relates to a controlled delivery system that can be incorporated in liquid, as well as, dry granular, or powder, household products, such as dishwashing detergents, surface cleaners, deodorizers, animal litters and cleaning wipes The system also prolongs the release rate of the active agents over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon heat treatment. The controlled delivery system of the present invention is a nano-sphere, having an average sphere diameter of from about 0.01 microns to about 10 microns. The nano-sphere comprises hydrophobic materials, cationic conditioning agent or, cationic conditioning agent in conjunction with a cationic charge booster to assist in adhering the spheres onto a surface.

Methods and compositions for triggering the delivery of an encapsulated therapeutic agent from a liposome are provided. Liposomes of opposite charge and incorporating lipids which favor non-lamellar structures are contacted in vivo. At least one of the liposome encapsulates at least one therapeutic drug or agent. Preferably, the liposomes have a fusogenic hydrophillic coating, such as PEG to control the rate of interaction of the liposomes and release of the therapeutic agent.

A drop tester (1) including a gripper mechanism (2) for holding a product (37) to be tested, a guide track, a slider block (3) which is mounted to slide along the guide track and advance the mechanism toward a target location (41) and a release device (40) for triggering release of the product from the mechanism to impact at the target location, characterised in that the gripper mechanism includes gripper arms (15, 16) coupled to the slider block, the gripper arms being rotatable relative to the slider block to enable the orientation of the product to be varied, relative to the target location. The slider block is preferably releasably coupled to a hoisting block (4) which is positionable at a predetermined location along the guide track. More preferably, the gripper arms are pivotally mounted to a housing (23) and coupled to a piston (22) provided within the housing, the arms pivoting between a gripping position and a release position upon advancement of the piston through the housing.

The present invention provides particle conjugates for drug delivery. Such conjugates comprise one or more heatable surfaces, one or more thermally-responsive linkers, and one or more agents to be delivered. In some embodiments, conjugates and populations of conjugates can be used to treat and / or diagnose a disease, disorder, and / or condition. The present invention provides methods for producing and / or using thermally-responsive conjugates.

A kit is provided to convert a compound archery bow into a left or right handed inline (vertical limb) crossbow. The conversion kit includes a mounting plate attachable to a side of the bow riser section to hold a socket to receive a draw-lock bar which can be removed for take-down and storage. The draw-lock bar has a series of laterally spaced bolt holes to attach a grip with a trigger release latch assembly at a selectable draw length. The bar can be rotated and attached to either side of the bow, and the trigger and grip can be reposition within the trigger housing for left, right or horizontal shooting. The string latch assembly has an anti-dryfire lever that is only moved from the blocking position when an arrow is nocked. The kit also provides a hinged cocking stirrup, and a front hand vertical grip on the riser side opposite the draw-bar socket. Also disclosed is a dedicated hybrid compound bow for dedicated use with kit as an inline or traditional crossbow. The hybrid compound bow is made especially. The hybrid bow has no forehand grip, and has a shoot through riser to provide vertical and horizontal centering of the arrow to the string.

A device for the rapid injection of a biological into the skin of a person. The device comprisies a hand-held applicator and a tape cassette adapted to be inserted into the applicator prior to use. The cassette houses a transportable tape having multiple doses of a biological disposed on a plurality of discrete clusters of microneedles affixed to the tape. In operation, a cassette is inserted into the applicator and a discrete cluster of microneedles advanced to a position adjacent a delivery opening in the applicator. A trigger advances the microneedle cluster to project outwardly through the delivery opening. The applicator is then pressed against the skin to force the cluster of microneedles into the skin. The applicator further includes means for applying an electric field between the microneedles and the skin to electrophoretically assist penetation of the biological into the skin. When the device is retracted from the skin and the trigger released, the next discrete cluster of biological-laden microneedles is advanced to underlie the delivery opening via a stepping tape transport means. The device may be used by relatively unskilled personnel to rapidly and painlessly vaccinate a large number of people.

A method for the encapsulation and triggered-release of water-soluble or water-dispersible materials. The method comprises a) providing an amount of electrolyte having a charge, b) providing an amount of counterion having a valence of at least 2, c) combining the polyelectrolyte and the counterion in a solution such that the polyelectrolyte self-assembles to form aggregates, d) adding a compound to be encapsulated, and e) adding nanoparticles to the solution such that nanoparticles arrange themselves around the aggregates. Release of the encapsulated species is triggered by disassembly or deformation of the microcapsules though disruption of the charge interactions. This method is specifically useful for the controlled viscosity reduction of the fracturing fluids commonly utilized in the oil field.

The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.

The present invention comprises a novel hammer and biasing system in a paintball pistol to achieve automatic re-cocking with closed bolt results in a marker pistol configuration typically associated with open bolt systems. The trigger releases a compressions hammer that nests in a hammer sleeve, but an aperture in the hammer sleeve permits a protrusion on the compression hammer to strike a poppet valve which releases a burst of gas. The gas pressure forced into the barrel causes the paint ball to be expelled from the barrel, and forces the hammer and bolt assembly aft due to increased pressure in the lower bore. The pressure against the front wall of a hammer sleeve pushes the hammer sleeve aft, along with the compression hammer. Also, because the bolt is interconnected to the hammer sleeve it is forced back in the upper barrel as well. When forced back, the bolt allows the breach to open and a paintball to drop into the chamber. Also, the sear catches the compression hammer in the cocked position. The interconnected combination of the hammer sleeve, bolt and slide cover causes the slide cover to move back as well. Springs interconnected between the slide cover and the housing are stretched when the slide cover moves back, but biases the slide cover to return to its forward position. Because the slide cover is interconnected to the bolt and hammer sleeve, the return of the slide cover forward by the springs, also resets the bolt and hammer sleeve to their forward ready to fire position.

An archery release aid for drawing the string of a bow using a substantially rigid cuff mounted on an archer's upper arm above the elbow comprising a substantially rigid cuff, a strap to transmit pulling force, and a means for attaching said archery release aid to known bow-string arrow trigger release devices. This archery release aid increases pull-force by relying on strength from the archer's upper arm and back instead of the lower arm and hand, and increases stability and shot accuracy by freeing the archer's hand and wrist from tension during release. Moving the point of pull above the elbow provides better leverage to the archer that allows him to pull a bow more easily or to pull a stronger bow than he would otherwise be able to pull. As the wrist is freed from tension the archer is better able to control release of the trigger, resulting in better consistency and accuracy of arrow placement.

A method for stabilizing an image and compensating for movement of a weapon is provided, comprising: providing an image stabilization device for an optical scope mounted on a weapon, wherein the image stabilization device includes a sensor to detect motion of the weapon; providing a trigger release device operatively connected to a trigger on the weapon; detecting movement of the weapon by the sensor; generating an output signal from the sensor, wherein the output signal corresponds to the position and velocity of the weapon in a plane perpendicular to the line of sight; processing the output signal to determine an optimal release period, and then generating a release signal during the release period; and using the release signal to activate the trigger release.

A jaw release mechanism for locking pliers which utilize an over-center toggle locking mechanism and wherein the normally stationary upper jaw of the pliers is pivotally fastened to the main body of the pliers. This normally stationary upper jaw is releaseably retained in a normally stationary position relative to the main body of the pliers by a thumb actuated trigger release mechanism whereby the locked pliers may be safely released with the same hand which grasps and manipulates the pliers.

A needle guard device mountable to a pre-filled syringe in its ready-to-fill state. The device includes a lock collar and a device shield biased to move relative to the lock collar. The lock collar interfaces with the syringe neck to attach the device to the syringe. A flexible member interconnects the lock collar and device shield. With the removal of a needle shield assembly comprising rigid and soft needle shields, the device shield is free to move proximally along the syringe neck. As the device moves proximally, rotation arms of the lock collar interact with angled cutouts in the device shield, causing the device shield to rotate relative to the lock collar disengaging one or more keys on the device shield from one or more keyways in the lock collar triggering the device shield to move from a first configuration in which the device shield is retractable to expose a syringe sharp to a second configuration in which the device shield is fixedly positioned to cover the syringe sharp.