12 results about "Triggered release" patented technology

Aspects of the present disclosure relate to an article. In some embodiments, the article is a gastric retention device or a gastrointestinal device. In some embodiments, the article comprises one or more reservoirs comprising a therapeutic payload. In some embodiments, the article comprises one or more triggerable release mechanisms. In some embodiments, the triggerable release mechanism comprises a metal seal. In some embodiments, release of the therapeutic payload is accomplished via electrochemical dissolution of the metal seal. Other aspects of the disclosure relate to methods for delivering a drug using the drug delivery articles disclosed herein.

The invention belongs to the technical field of biomedical materials and targeted drug delivery systems, and discloses a targeted controlled-release drug delivery system based on a polymer nano-carrier and a preparation method thereof.The system is of a three-layer structure and comprises a core layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping a drug, and an outer layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping the drug; the shell layer formed by the polylactic acid-glycolic acid copolymer is used for providing structural stability and slow release capability, and the shell layer formed by the polyvinyl alcohol-hydroformylated glucan grafted copolymer is used for realizing microenvironment response release. And the surface of the shell layer is covalently modified with a tumor membrane targeting aptamer and a microenvironment response peptide, so that accurate recognition and local trigger release can be realized. The system has good particle size stability, responsive release ability and tumor cell targeted enrichment effect, and is suitable for efficient delivery and controlled release of various antitumor drugs.

An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

The invention discloses a brand new carrier-based siRNA drug targeting delivery method, and belongs to the technical field of biological medicine, the delivery system comprises: a core layer: nanoparticles formed by loading siRNA on a biodegradable polymer (such as PLGA, molecular weight of 10,000-100,000 Da); the middle layer is a pH sensitive polymer (such as PDEAEMA) coating the core layer and is triggered to release in a target tissue acidic microenvironment (pH is less than or equal to 6.5); and the outer layer is a targeting ligand (such as an anti-EGFR / c-Met antibody fragment, the connection density is 1-10 / nm), and specific enrichment is realized. Through the design of the intelligent responsive nano-carrier, the problem of biological distribution heterogeneity is effectively solved, the delivery efficiency of siRNA drugs in target tissues of different patients is improved, the treatment effect is more stable and reliable, and the application prospect is wide. The nano-carrier is constructed by adopting a biodegradable material with low immunogenicity, so that the drug resistance risk is remarkably reduced, the in-vivo circulation time of the carrier is prolonged, and a guarantee is provided for long-term treatment of siRNA drugs.

The invention discloses a field predation-preventing seed feeding device. The technical problems that existing field seeds are prone to being predded by animals, the survival rate is low, and the growth condition is insufficient are solved. The device comprises a hollow and degradable cylinder body, a circle of slow descending resistance sheets are arranged outside the cylinder body, a storage mechanism for storing a repelling agent is detachably mounted at the top of the cylinder body, and an inoculation bin is inserted into the bottom of the cylinder body; a driving rod is vertically arranged in the barrel, the two ends of the driving rod are connected with the storage mechanism and the seed bin respectively, and when the seed bin falls to the ground, the driving rod moves upwards to transmit impact kinetic energy to the storage mechanism to release the repelling agent. The storage mechanism realizes pressed storage and impact trigger release of the repelling agent through an elastic sheet and a clamping assembly; a nutrient bin is arranged at the top of the seed bin, and a puncture needle on the directional moving plate can puncture a nutrient bin sealing hole to achieve nutrient slow release. Through slow descent and directional landing, automatic release of the repelling agent for preventing predation and slow release supply of nutrients, the survival rate of the field seeds is remarkably increased, and the whole body is degradable and environment-friendly.

This invention belongs to the field of pesticide technology and discloses a synergistic ant-killing powder based on traditional Chinese medicine extracts. This powder uses aminated modified biochar as a bifunctional carrier, loading a complex of active ingredients including triptolide and rotenone. It addresses the problems of short duration of action and poor targeting of existing plant-derived ant killers through an electrostatic adsorption-slow-release synergistic mechanism. Its components include 65%–85% aminated modified biochar, 3%–8% triptolide, 2%–6% rotenone, 5%–15% flow aid, and 1%–3% anti-caking agent. The carrier is prepared from agricultural waste through oxygen-limited pyrolysis and silane grafting, possessing a high specific surface area and controllable pore size, which can stably anchor the active ingredients and trigger release in the alkaline microenvironment of ants. This ant-killing powder extends the duration of action, improves efficacy utilization, and has low toxicity to non-target organisms, making it suitable for green pest control in various scenarios.

The invention relates to a heating and ventilation radiation heating and deoxidizing device with a slow-release effect, a water distributing and collecting device and a method. The heating and ventilation radiation heating and deoxidizing device with the slow-release effect comprises a pipe body, a memory alloy slow-release unit is arranged at the top of the pipe body, and a magnetic field driving and dispersing unit is arranged at the bottom of the pipe body; the memory alloy slow-release unit comprises a temperature response release type carrier unit and a magnetic field regulation and control release type carrier unit, the bottom of the temperature response release type carrier unit is sealed through a first memory alloy, the bottom of the magnetic field regulation and control release type carrier unit is sealed through a second memory alloy, and the second memory alloy regulates and controls deformation through a magnetic field; deoxidant is packaged in the closed temperature response release type carrier unit and the magnetic field regulation and control release type carrier unit. Release of the deoxidant can be automatically adjusted according to the water temperature of the system, and forced mixing and remote trigger release of the deoxidant are achieved by means of an external force field, so that the effects of efficient corrosion prevention, energy conservation, consumption reduction, prolonging of the service life of the system and reduction of maintenance frequency are achieved.

The invention discloses a kidney local drug delivery system guided by a multi-modal image based on an astragalus membranaceus extract. According to the invention, the intelligent pH response type drug carrier can perform drug release in allusion to an acidic microenvironment of a kidney lesion area, and the design greatly improves the accuracy of treatment. The pH sensitive polymer such as poly (-amino acid) or polyacrylate is structurally changed in an acidic environment, so that the release of the astragalus extract is triggered, the environment-triggered release mechanism ensures that the medicine is released after reaching a target part, and the loss of the medicine in blood circulation and the damage to non-target tissues are reduced. Besides, the radix astragali extract loading module ensures high drug loading capacity and stability of drugs through an efficient loading process, so that active ingredients in radix astragali can reach a treatment concentration at a kidney lesion part, and pharmacological effects of anti-inflammation, anti-oxidation, immunoregulation and the like of the active ingredients are exerted.

The invention relates to the technical field of pharmaceutical preparations, in particular to an oral mucosa absorption gargle tablet based on black cimicifuga foetida extract, which is composed of the following components in percentage by mass: 30% of quick release layer and 70% of slow release layer, the quick release layer is composed of black cimicifuga foetida nano-liposome, a disintegrating agent and a penetration enhancer, and the slow release layer is composed of a disintegrating agent and a penetration enhancer. The quick release layer is composed of black cimicifuga foetida nano-liposome, a disintegrating agent and a penetration enhancer according to a mass ratio of 4: 1: 1, and the slow release layer is composed of chitosan, soy isoflavone, a pH sensitive material and a flavoring agent; through the double-layer structure design of the quick release layer (disintegration time is less than or equal to 5 seconds) and the slow release layer (pH is greater than or equal to 6.5 to trigger release), the quick effect (inhibiting hectic fever in 10 minutes) and the continuous effect (releasing 78% of soybean isoflavone in 8 hours) of the active ingredients are realized, and the preparation is obviously superior to the traditional oral preparation (the effect is realized in 45 minutes, and the release rate lt in a gastric acid environment is 5%).

The invention discloses a nano-carrier for precise sequential controlled release of a synergistic drug and a preparation method. The preparation method comprises the following steps: preparing a prussian blue nano-cage loaded with 5-fluorouracil; the outer layer of the Prussian blue nanocage is coated with the methotrexate functionally modified hyaluronic acid; and constructing a co-delivery carrier 5-FU (at) PB Cage / MTX loaded with a synergistic drug. The carrier triggers MTX release in a tumor site slightly acidic environment; after a required time interval, near-infrared light is applied to the enriched part of the carrier, the local temperature is increased by means of the photothermal conversion effect of PB Cage, the phase change material is promoted to melt and flow out, and then controllable release of 5-FU is achieved. The problems that a traditional co-delivery carrier is disordered in time sequence and poor in synergistic effect are solved, a brand new carrier design thought is provided for precise tumor chemotherapy, and important theoretical and application values are achieved for promoting conversion of nano-drugs from basic research to clinic, improving tumor treatment efficiency and reducing toxic and side effects.

The invention discloses a preparation method of water-in-oil Pickering emulsion gel loaded with a two-phase medicine and application of the water-in-oil Pickering emulsion gel loaded with the two-phase medicine. According to the method, an amino polymer with positive charges is dissolved in oil to serve as an oil phase, nano-particles with negative charges are dispersed in water to serve as a water phase, the oil phase and the water phase are mixed and emulsified to prepare the water-in-oil Pickering emulsion gel, and the water-in-oil Pickering emulsion gel has good stability and biocompatibility and can serve as an excellent drug delivery platform; the simultaneous loading of hydrophilic and hydrophobic active substances is realized. The degradation rate of the prepared Pickering emulsion gel can be controllably adjusted by adjusting the adding proportion of iodized oil and castor oil in the oil phase, release can be triggered under the ultrasonic action, and controlled release of the water-in-oil Pickering emulsion gel is achieved by adjusting and controlling different oil-water phase compositions, ultrasonic power and ultrasonic time. The prepared Pickering emulsion gel can be used for realizing efficient packaging of a hydrophobic sound sensitive agent, and can be used for realizing anti-tumor treatment through sonodynamic therapy.

The invention relates to the technical field of pesticide preparations, in particular to a pesticide-loaded capsule and a preparation method thereof. The drug-loaded capsule is prepared by the following method: (1) emulsifying a water phase containing polyvinyl alcohol and an emulsifier and an oil phase containing a drug to obtain an oil-in-water emulsion; (2) carrying out cross-linking reaction on the oil-in-water emulsion and a boron cross-linking agent to obtain a drug-loaded capsule; wherein relative to 1 g of polyvinyl alcohol, the dosage of the boron crosslinking agent is 0.01-2 g. The preparation method disclosed by the invention is simple, and the obtained drug-loaded capsule is high in encapsulation efficiency and long in slow release period, can be accurately adapted to a slightly acidic rhizosphere environment to trigger release, and has excellent ecological compatibility to the environment and crops.