4 results about "Triggered release" patented technology

An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

This invention belongs to the field of pesticide technology and discloses a synergistic ant-killing powder based on traditional Chinese medicine extracts. This powder uses aminated modified biochar as a bifunctional carrier, loading a complex of active ingredients including triptolide and rotenone. It addresses the problems of short duration of action and poor targeting of existing plant-derived ant killers through an electrostatic adsorption-slow-release synergistic mechanism. Its components include 65%–85% aminated modified biochar, 3%–8% triptolide, 2%–6% rotenone, 5%–15% flow aid, and 1%–3% anti-caking agent. The carrier is prepared from agricultural waste through oxygen-limited pyrolysis and silane grafting, possessing a high specific surface area and controllable pore size, which can stably anchor the active ingredients and trigger release in the alkaline microenvironment of ants. This ant-killing powder extends the duration of action, improves efficacy utilization, and has low toxicity to non-target organisms, making it suitable for green pest control in various scenarios.

The invention relates to a heating and ventilation radiation heating and deoxidizing device with a slow-release effect, a water distributing and collecting device and a method. The heating and ventilation radiation heating and deoxidizing device with the slow-release effect comprises a pipe body, a memory alloy slow-release unit is arranged at the top of the pipe body, and a magnetic field driving and dispersing unit is arranged at the bottom of the pipe body; the memory alloy slow-release unit comprises a temperature response release type carrier unit and a magnetic field regulation and control release type carrier unit, the bottom of the temperature response release type carrier unit is sealed through a first memory alloy, the bottom of the magnetic field regulation and control release type carrier unit is sealed through a second memory alloy, and the second memory alloy regulates and controls deformation through a magnetic field; deoxidant is packaged in the closed temperature response release type carrier unit and the magnetic field regulation and control release type carrier unit. Release of the deoxidant can be automatically adjusted according to the water temperature of the system, and forced mixing and remote trigger release of the deoxidant are achieved by means of an external force field, so that the effects of efficient corrosion prevention, energy conservation, consumption reduction, prolonging of the service life of the system and reduction of maintenance frequency are achieved.

The invention discloses a nano-carrier for precise sequential controlled release of a synergistic drug and a preparation method. The preparation method comprises the following steps: preparing a prussian blue nano-cage loaded with 5-fluorouracil; the outer layer of the Prussian blue nanocage is coated with the methotrexate functionally modified hyaluronic acid; and constructing a co-delivery carrier 5-FU (at) PB Cage / MTX loaded with a synergistic drug. The carrier triggers MTX release in a tumor site slightly acidic environment; after a required time interval, near-infrared light is applied to the enriched part of the carrier, the local temperature is increased by means of the photothermal conversion effect of PB Cage, the phase change material is promoted to melt and flow out, and then controllable release of 5-FU is achieved. The problems that a traditional co-delivery carrier is disordered in time sequence and poor in synergistic effect are solved, a brand new carrier design thought is provided for precise tumor chemotherapy, and important theoretical and application values are achieved for promoting conversion of nano-drugs from basic research to clinic, improving tumor treatment efficiency and reducing toxic and side effects.