7 results about "Triggered release" patented technology

The invention belongs to the technical field of biomedical materials and targeted drug delivery systems, and discloses a targeted controlled-release drug delivery system based on a polymer nano-carrier and a preparation method thereof.The system is of a three-layer structure and comprises a core layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping a drug, and an outer layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping the drug; the shell layer formed by the polylactic acid-glycolic acid copolymer is used for providing structural stability and slow release capability, and the shell layer formed by the polyvinyl alcohol-hydroformylated glucan grafted copolymer is used for realizing microenvironment response release. And the surface of the shell layer is covalently modified with a tumor membrane targeting aptamer and a microenvironment response peptide, so that accurate recognition and local trigger release can be realized. The system has good particle size stability, responsive release ability and tumor cell targeted enrichment effect, and is suitable for efficient delivery and controlled release of various antitumor drugs.

An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

The invention discloses a field predation-preventing seed feeding device. The technical problems that existing field seeds are prone to being predded by animals, the survival rate is low, and the growth condition is insufficient are solved. The device comprises a hollow and degradable cylinder body, a circle of slow descending resistance sheets are arranged outside the cylinder body, a storage mechanism for storing a repelling agent is detachably mounted at the top of the cylinder body, and an inoculation bin is inserted into the bottom of the cylinder body; a driving rod is vertically arranged in the barrel, the two ends of the driving rod are connected with the storage mechanism and the seed bin respectively, and when the seed bin falls to the ground, the driving rod moves upwards to transmit impact kinetic energy to the storage mechanism to release the repelling agent. The storage mechanism realizes pressed storage and impact trigger release of the repelling agent through an elastic sheet and a clamping assembly; a nutrient bin is arranged at the top of the seed bin, and a puncture needle on the directional moving plate can puncture a nutrient bin sealing hole to achieve nutrient slow release. Through slow descent and directional landing, automatic release of the repelling agent for preventing predation and slow release supply of nutrients, the survival rate of the field seeds is remarkably increased, and the whole body is degradable and environment-friendly.

This invention belongs to the field of pesticide technology and discloses a synergistic ant-killing powder based on traditional Chinese medicine extracts. This powder uses aminated modified biochar as a bifunctional carrier, loading a complex of active ingredients including triptolide and rotenone. It addresses the problems of short duration of action and poor targeting of existing plant-derived ant killers through an electrostatic adsorption-slow-release synergistic mechanism. Its components include 65%–85% aminated modified biochar, 3%–8% triptolide, 2%–6% rotenone, 5%–15% flow aid, and 1%–3% anti-caking agent. The carrier is prepared from agricultural waste through oxygen-limited pyrolysis and silane grafting, possessing a high specific surface area and controllable pore size, which can stably anchor the active ingredients and trigger release in the alkaline microenvironment of ants. This ant-killing powder extends the duration of action, improves efficacy utilization, and has low toxicity to non-target organisms, making it suitable for green pest control in various scenarios.

The invention relates to a heating and ventilation radiation heating and deoxidizing device with a slow-release effect, a water distributing and collecting device and a method. The heating and ventilation radiation heating and deoxidizing device with the slow-release effect comprises a pipe body, a memory alloy slow-release unit is arranged at the top of the pipe body, and a magnetic field driving and dispersing unit is arranged at the bottom of the pipe body; the memory alloy slow-release unit comprises a temperature response release type carrier unit and a magnetic field regulation and control release type carrier unit, the bottom of the temperature response release type carrier unit is sealed through a first memory alloy, the bottom of the magnetic field regulation and control release type carrier unit is sealed through a second memory alloy, and the second memory alloy regulates and controls deformation through a magnetic field; deoxidant is packaged in the closed temperature response release type carrier unit and the magnetic field regulation and control release type carrier unit. Release of the deoxidant can be automatically adjusted according to the water temperature of the system, and forced mixing and remote trigger release of the deoxidant are achieved by means of an external force field, so that the effects of efficient corrosion prevention, energy conservation, consumption reduction, prolonging of the service life of the system and reduction of maintenance frequency are achieved.

The invention discloses a nano-carrier for precise sequential controlled release of a synergistic drug and a preparation method. The preparation method comprises the following steps: preparing a prussian blue nano-cage loaded with 5-fluorouracil; the outer layer of the Prussian blue nanocage is coated with the methotrexate functionally modified hyaluronic acid; and constructing a co-delivery carrier 5-FU (at) PB Cage / MTX loaded with a synergistic drug. The carrier triggers MTX release in a tumor site slightly acidic environment; after a required time interval, near-infrared light is applied to the enriched part of the carrier, the local temperature is increased by means of the photothermal conversion effect of PB Cage, the phase change material is promoted to melt and flow out, and then controllable release of 5-FU is achieved. The problems that a traditional co-delivery carrier is disordered in time sequence and poor in synergistic effect are solved, a brand new carrier design thought is provided for precise tumor chemotherapy, and important theoretical and application values are achieved for promoting conversion of nano-drugs from basic research to clinic, improving tumor treatment efficiency and reducing toxic and side effects.

The invention discloses a preparation method of water-in-oil Pickering emulsion gel loaded with a two-phase medicine and application of the water-in-oil Pickering emulsion gel loaded with the two-phase medicine. According to the method, an amino polymer with positive charges is dissolved in oil to serve as an oil phase, nano-particles with negative charges are dispersed in water to serve as a water phase, the oil phase and the water phase are mixed and emulsified to prepare the water-in-oil Pickering emulsion gel, and the water-in-oil Pickering emulsion gel has good stability and biocompatibility and can serve as an excellent drug delivery platform; the simultaneous loading of hydrophilic and hydrophobic active substances is realized. The degradation rate of the prepared Pickering emulsion gel can be controllably adjusted by adjusting the adding proportion of iodized oil and castor oil in the oil phase, release can be triggered under the ultrasonic action, and controlled release of the water-in-oil Pickering emulsion gel is achieved by adjusting and controlling different oil-water phase compositions, ultrasonic power and ultrasonic time. The prepared Pickering emulsion gel can be used for realizing efficient packaging of a hydrophobic sound sensitive agent, and can be used for realizing anti-tumor treatment through sonodynamic therapy.