Preparation of photothermally responsive drug sustained-release hydrogel based on magnetic cellulose nanocrystals

A photothermal response, cellulose technology, applied in the photodissociation of drugs in vivo, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of poor flexibility of hydrogels and limit practical applications , easy to brittle and other problems, to achieve the effect of good mechanical tensile properties

Active Publication Date: 2021-05-18
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor mechanical properties of the polymer, the prepared hydrogel has poor flexibility, and the tensile breaking strength is only 5kPa, which is easy to be brittle, which also limits the practical application of this type of hydrogel.

Method used

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  • Preparation of photothermally responsive drug sustained-release hydrogel based on magnetic cellulose nanocrystals
  • Preparation of photothermally responsive drug sustained-release hydrogel based on magnetic cellulose nanocrystals
  • Preparation of photothermally responsive drug sustained-release hydrogel based on magnetic cellulose nanocrystals

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Step 1, using acid hydrolysis method to extract CNC solution from plant material. Specifically: Add a certain quality of plant raw materials into a 1:1 mixed solution of concentrated sulfuric acid and deionized water, heat and hydrolyze at 65°C for 1.5 hours, stop heating and add deionized water to dilute, let stand overnight, and remove the supernatant , centrifugal cleaning, dialysis, and ultrasonication to obtain a CNC solution.

[0035] Step 2, get CNC solution (mass fraction is 1.1wt%), add different valence iron ions, Fe 2+ , Fe 3+ The molar ratio of ammonia and ammonia is 1.1:2:10, under alkaline conditions (controlling and adjusting the pH value is greater than 10) and in-situ synthesis of magnetic nanoparticles on the CNC (the mass ratio of CNC to the generated magnetic nanoparticles is 12:1 ), reacted at 75°C for 15 minutes to obtain a colloidal solution;

[0036] Step 3: Take 5 g of the colloidal solution obtained in Step 2, add 1 g of high molecular weigh...

Embodiment 2

[0039] The specific method and steps are mostly the same as in Example 1, except that in step 3, no crosslinking agent is added.

[0040] From figure 1 and figure 2 It can be seen that the entanglement density of the polymer network is significantly reduced when no cross-linking agent is added.

Embodiment 3

[0042] The specific method and steps are mostly the same as in Example 1, except that in step 3, the amount of added polymer monomer is 0.8 g.

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Abstract

The present invention relates to a preparation method of a photothermal response drug slow-release hydrogel based on magnetic cellulose nanocrystals, comprising the following steps: (1) preparing a CNC solution from a plant material by acid hydrolysis; (2) adding it to the CNC solution, Introduce iron ions of different valence states, and synthesize magnetic nanoparticles in situ under alkaline conditions to obtain a colloidal solution; (3) add polymer monomers, initiators, crosslinking agents and Catalyst, reaction, that is, to obtain the target product. Compared with the prior art, the present invention uses CNC solution as the raw material, based on the in-situ growth of magnetic nanoparticles, and by adding different contents and different types of polymers, the preparation of photothermally responsive drug-loaded hydrogels and photothermal response can be realized. controlled drug release.

Description

technical field [0001] The invention belongs to the technical field of gel materials, and relates to the preparation of a photothermal response drug slow-release hydrogel based on magnetic cellulose nanocrystals. Background technique [0002] With the continuous development of science and technology, people's demand for hydrogel is increasing, and its functional requirements are also getting higher and higher. Poly-N-isopropylacrylamide (PNIPAm) and poly-N,N-diethylacrylamide (PDEAm) have a phase transition characteristic from hydrophilic to hydrophobic when the temperature is higher than 32 °C, which is the same temperature as the human body. Body temperature is similar, so this polymer is widely used in the preparation of hydrogels. However, due to the poor mechanical properties of the polymer, the prepared hydrogel has poor flexibility, and the tensile breaking strength is only 5kPa, which is easy to be brittle, which also limits the practical application of this type of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/54C08F222/38C08F120/54C08K3/22A61K9/06A61K41/00A61K47/32A61K47/38
CPCA61K9/06A61K41/0042A61K47/32A61K47/38C08F120/54C08F220/54C08K3/22C08K2003/2275C08K2201/01C08K2201/011C08F222/385
Inventor 朱申敏陈天星李尧陶杰孟鑫袁豪
Owner SHANGHAI JIAO TONG UNIV
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