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Preparation of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals

A photothermal response, cellulose technology, which is applied in the photo-splitting of drugs in the body, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of poor flexibility and brittleness of hydrogels. , limit practical application and other issues, to achieve the effect of good mechanical tensile properties

Active Publication Date: 2020-03-24
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor mechanical properties of the polymer, the prepared hydrogel has poor flexibility, and the tensile breaking strength is only 5kPa, which is easy to be brittle, which also limits the practical application of this type of hydrogel.

Method used

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  • Preparation of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals
  • Preparation of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals
  • Preparation of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Step 1, using acid hydrolysis method to extract CNC solution from plant material. Specifically: Add a certain quality of plant raw materials into a 1:1 mixed solution of concentrated sulfuric acid and deionized water, heat and hydrolyze at 65°C for 1.5 hours, stop heating and add deionized water to dilute, let stand overnight, and remove the supernatant , centrifugal cleaning, dialysis, and ultrasonication to obtain a CNC solution.

[0035] Step 2, get CNC solution (mass fraction is 1.1wt%), add different valence iron ions, Fe 2+ , Fe 3+ The molar ratio of adding ammonia water is 1.1:2:10, under alkaline conditions (controlling and adjusting the pH value is greater than 10) and in-situ synthesis of magnetic nanoparticles on the CNC (the mass ratio of CNC to the generated magnetic nanoparticles is 12:1 ), reacted at 75°C for 15 minutes to obtain a colloidal solution;

[0036] Step 3: Take 5 g of the colloidal solution obtained in Step 2, add 1 g of high molecular weig...

Embodiment 2

[0039] The specific method and steps are mostly the same as in Example 1, except that in step 3, no crosslinking agent is added.

[0040] from figure 1 and figure 2 It can be seen that the entanglement density of the polymer network is significantly reduced when no cross-linking agent is added.

Embodiment 3

[0042] The specific method and steps are mostly the same as in Example 1, except that in step 3, the amount of added polymer monomer is 0.8 g.

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Abstract

The invention relates to a preparation method of photo-thermal response drug sustained-release hydrogel based on magnetic cellulose nanocrystals. The preparation method comprises the following steps:(1) preparing a CNC solution from plant raw materials by using an acid hydrolysis method; (2) introducing iron ions with different valence states into the CNC solution, and synthesizing magnetic nanoparticles in situ under an alkaline condition to obtain a colloidal solution; and (3) adding a polymer monomer, an initiator, a cross-linking agent and a catalyst into the colloidal solution obtained in the step (2), and reacting to obtain the target product. Compared with the prior art, the CNC solution is taken as a raw material, in-situ growth of the magnetic nanoparticles is taken as a basis, and different types of polymers with different contents are added, so that preparation of photo-thermal response drug-loaded hydrogel and light-operated drug release can be realized.

Description

technical field [0001] The invention belongs to the technical field of gel materials, and relates to the preparation of a photothermal response drug slow-release hydrogel based on magnetic cellulose nanocrystals. Background technique [0002] With the continuous development of science and technology, people's demand for hydrogel is increasing, and its functional requirements are also getting higher and higher. Poly-N-isopropylacrylamide (PNIPAm) and poly-N,N-diethylacrylamide (PDEAm) have a phase transition characteristic from hydrophilic to hydrophobic when the temperature is higher than 32 °C, which is the same temperature as the human body. Body temperature is similar, so this polymer is widely used in the preparation of hydrogels. However, due to the poor mechanical properties of the polymer, the prepared hydrogel has poor flexibility, and the tensile breaking strength is only 5kPa, which is easy to be brittle, which also limits the practical application of this type of...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F222/38C08F120/54C08K3/22A61K9/06A61K41/00A61K47/32A61K47/38
CPCA61K9/06A61K41/0042A61K47/32A61K47/38C08F120/54C08F220/54C08K3/22C08K2003/2275C08K2201/01C08K2201/011C08F222/385
Inventor 朱申敏陈天星李尧陶杰孟鑫袁豪
Owner SHANGHAI JIAO TONG UNIV
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