Unlock instant, AI-driven research and patent intelligence for your innovation.
A kind of single light-activated nanoparticle and its preparation method and application
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A nanoparticle, light-activated technology, applied in the field of medicine, can solve the problems of limited effect and need of combination therapy
Active Publication Date: 2020-11-24
NANKAI UNIV
View PDF1 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Although the absorption wavelength of the above-mentioned photosensitizer can match the absorption wavelength of general photothermal preparations, which solves the problem of needing dual lasers, the final combination therapy effect is still limited due to the severe oxygen dependence in PDT treatment.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0036] The present invention also provides a method for preparing single light-activated nanoparticles described in the above technical solution, comprising the following steps:
[0039] The invention provides hollow bismuth selenide nanoparticles. In the present invention, the method for preparing hollow bismuth selenide nanoparticles preferably includes the following steps: providing porous bismuth oxide nanoparticles, and preparing hollow bismuth selenide nanoparticles by using the porous bismuth oxide nanoparticles as templates.
[0040] In the present invention, the preparation method of the porous bismuth oxide nanoparticles preferably includes the following steps: mixing a bismuth salt, an acidic solution, an a...
Embodiment 1
[0052] (1) After mixing bismuth nitrate pentahydrate (0.485g, 1.19mmol) and nitric acidaqueous solution (13mL, 1mol / L), sodiumhydroxide (0.144g, 3.6mmol), PVP (0.6g, Mw=10000 ) and ethylene glycol (57mL), stirred at 500rpm until the raw materials were completely dissolved, then transferred the resulting reaction solution to a stainless steel reactor, reacted at 150°C for 3h, cooled the resulting system to room temperature and centrifuged (10000r / min, 15min), the resulting solid material was washed 4 times, and dried in a vacuum oven for 48h to obtain porous bismuth oxide nanoparticles;
[0053] (2) Dissolve sodium selenite (0.0432g, 0.25mmol), ascorbic acid (0.4g, 2.27mmol) in deionized water (30mL), add porous bismuth oxide nanoparticle aqueous solution (0.9mL, 0.1mmol / L) , mixed evenly, transferred to the reaction kettle, reacted at 150°C for 12h, cooled the obtained system to room temperature and then centrifuged (10000r / min, 15min), washed the obtained solid material 4 ...
Embodiment 2
[0060] Prepare Bi according to the method of embodiment 1 2 Se 3 @AIPH nanoparticle, the difference from Example 1 is that sodiumhydroxide is replaced by urea (0.213g, 3.55mmol) in step (1);
[0061] Measured by thermogravimetric analysis and UV-visible spectrophotometer, the Bi prepared in this embodiment 2 Se 3 The total loading of @AIPH nanoparticles lauric acid and AIPH was 17.5%, and the loading of AIPH was 11.7%.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention provides a single light-activated nano particle and a preparation method and application thereof, and belongs to the technical field of medicine. The single light-activated nano particlecomprises a hollow bismuthselenide nano particle, a phase-change material and a radical initiator, wherein the phase-change material and the radical initiator are loaded in the hollow bismuthselenide nano particle. The single light-activated nano particle is in laserradiation, absorbed light energy is converted to hyperthermia, cancer cells are directly killed, the phase-change material further can be prompted to melt, so that the radical initiator is released and split, generated free radical can cause cellmembrane lipid peroxidation, glutathione is consumed, DNA is damaged, and thus thecancer cells are removed further. By detecting in vitrocytotoxicity and in vivo anti-cancer function, it is proved that the single light-activated nano particle has superior tumor killing capacity,and efficient photo-thermal and photodynamic combined therapy is realized through the hyperthermia and hyperthermiacascade activated free radical.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a single light-activated nanoparticle and its preparation method and application. Background technique [0002] Malignant tumors are one of the killers of human health. Traditional therapies have poor specificity and strong side effects. Light therapy is a method of using sunlight or artificial light (infrared, ultraviolet, visible light, laser) to prevent and treat diseases and promote the recovery of the body. Phototherapy has attracted extensive attention in the treatment of tumors due to its good spatiotemporal precision and non-invasiveness. Among them, photothermal therapy is to use materials with high photothermal conversion efficiency, inject them into the human body, use targeted recognition technology to gather near the tumor tissue, and irradiate them with an external light source (usually near-infrared light). A treatment that converts light energy into heat to kil...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More