Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Nanoparticle photothermal conversion material based on coordination of iron and dopamine and preparation method and application thereof

A photothermal conversion material and nanoparticle technology, applied in the field of nanoparticle photothermal conversion materials and their preparation, can solve the problems of morphology and particle size control, no coordination structure, multiple biological toxic components, etc., and achieve a good shape. appearance, low biological toxicity, and the effect of material green and environmental protection

Active Publication Date: 2020-06-19
HUNAN UNIV
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the current research is more focused on using the properties of the precursor raw materials to construct nanoparticles. The function of the synthesized nanoparticles depends on the properties of the precursor compounds, and it is difficult to realize the development and application of new functions, or to combine photosensitizers or Thermosensitizers and chemotherapeutic drugs loaded inside nanomaterials
These methods usually require relatively complicated synthesis steps, high energy consumption, and the photothermal conversion performance and therapeutic ability of materials are more dependent on the loading capacity of nanomaterials and the amount of loaded drugs.
At the same time, an overly complex construction scheme may introduce more biotoxic components, which limits its further application in the biomedical field
In addition, methods based on the coordination of iron and polyphenols to form nanoparticles have been partially reported (Naturecommunications, 2015, 6, 8003; Advanced healthcare materials, 2016, 5, 772; Nanoscale, 2017, 9, 12609; International Journal of Nanomedicine, 2017, 12, 7207; Small, 2018, 14, 1702700), however, this type of material does not have a stable coordination structure, and it needs to add a large amount of stabilizer to form nanoparticles during the synthesis process, so it is difficult to Morphology and particle size control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nanoparticle photothermal conversion material based on coordination of iron and dopamine and preparation method and application thereof
  • Nanoparticle photothermal conversion material based on coordination of iron and dopamine and preparation method and application thereof
  • Nanoparticle photothermal conversion material based on coordination of iron and dopamine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A method for preparing a nanoparticle photothermal conversion material based on iron and dopamine coordination, specifically comprising the following steps:

[0049] (1) Weigh 9.72g ferric chloride hexahydrate (FeCl 3 ·6H 2 (2) and 3.24g trimesic acid (trimesic acid), fully dissolved in 120mL pure water, stirring and mixing, to obtain a mixed solution;

[0050] (2) Transfer the mixed solution into a polytetrafluoroethylene hydrothermal reaction kettle, and react at 130°C for 36h-48h. After the reaction is completed, a brownish yellow suspension is obtained, which is naturally cooled to room temperature, and the supernatant is removed by centrifugation. Repeatedly wash and centrifuge the precipitate with methanol and water for 3-6 times, the centrifugation speed is 8000-10000r / min, and the centrifugation time is 10-20min each time, until the supernatant is basically colorless; After drying at ℃, a brown-yellow powder is obtained, which is nano-scale iron-based metal-or...

Embodiment 2

[0054] The photothermal treatment effect of the loaded DA-Fe-MOF-PEG nanomaterial prepared in Example 1 is further tested below.

[0055] 1. Photothermal conversion ability test

[0056] Method: The prepared DA-Fe-MOF-PEG nanomaterials were prepared into a PBS solution with a certain gradient concentration with PBS buffer salt. Placed in a quartz cuvette, use 808nm near-infrared laser at 2W / cm 2 Irradiated at a certain laser power for 10 minutes to detect its heating capacity. At the same time, the material solution with a concentration of 400 μg / mL was repeatedly tested for 5 rounds of temperature rise to verify its photothermal stability.

[0057] Result: if Figure 5 As shown, under near-infrared laser irradiation, the material of the present invention has good photothermal conversion ability. When the concentration is above 500 μg / mL, the final concentration can reach above 40 degrees Celsius. At the same time, the synthesized nanoparticles of the present invention ha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
photothermal conversion efficiencyaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of photothermal conversion materials, and discloses a nanoparticle photothermal conversion material based on coordination of iron and dopamine and a preparation method and application thereof. The preparation method comprises the following operation steps of: firstly, preparing a nanoscale iron-based metal organic framework by using a hydrothermal synthesis method; and then combining the dopamine in the nanoscale iron-based metal organic framework through the action of a coordination bond by virtue of a coordination effect of phenolic hydroxyl on the dopamine and the iron on the iron-based metal organic framework, so as to obtain the nanoparticle photothermal conversion material based on coordination of the iron and the dopamine. The material can be well applied to photothermal therapy drug preparation, photoacoustic imaging, nuclear magnetic imaging, drug loading or functional modification.

Description

technical field [0001] The invention belongs to the technical field of light-to-heat conversion materials, in particular to a nano-particle light-to-heat conversion material based on iron and dopamine coordination and its preparation method and application. Background technique [0002] As one of the important methods for constructing nanomaterials, chemical self-assembly has been widely concerned and applied in molecular catalysis, energy materials, surface engineering, especially in the fields of life science and nanomedicine. In the process of self-assembly, basic structural units organize or aggregate into a stable structure through non-covalent interactions. Compared with hydrogen bonds, π–π interactions, electrostatic interactions, and dipole interactions, transition metal-ligand coordination interactions have attracted extensive attention due to their ease of design and control. Chemical self-assembly combines the abundant reactivity of transition metal ions with hig...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/10A61K41/00A61P35/00A61K47/18A61K47/02
CPCA61K49/225A61K49/1833A61K49/101A61K41/0052A61P35/00A61K47/18A61K47/02Y02A20/212
Inventor 游常军刘艳岚孔维恒
Owner HUNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products