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Platinum-based monatomic nano-enzyme for combined treatment of tumors and preparation method thereof

A nano-enzyme and atomic technology, applied in the field of nano-materials, can solve the problems of single photothermal effect and the inability to realize the effect of dual-enzyme active radiotherapy, etc., and achieve the effect of good photothermal conversion ability, excellent OH generation ability, and simple and fast preparation method

Active Publication Date: 2021-07-16
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The existing technology is that divalent platinum (II) base and 3,4-diaminopyridine are used as precursors to prepare a new type of platinum (II)-based polypyridine nano-drug (Pt(II)-PDAP), which The main effect is that the new nano-medicine has a strong absorption in the near-infrared region. The nano-medicine has good photothermal conversion efficiency and photostability through infrared thermal imager monitoring. Therefore, it can be used as a photothermal absorption reagent in bacterial light. However, the polypyridine nanomedicine of platinum (II) (Pt(II)-PDAP) only has a single photothermal effect, and cannot achieve the radiotherapy effect of dual enzyme activity

Method used

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  • Platinum-based monatomic nano-enzyme for combined treatment of tumors and preparation method thereof
  • Platinum-based monatomic nano-enzyme for combined treatment of tumors and preparation method thereof
  • Platinum-based monatomic nano-enzyme for combined treatment of tumors and preparation method thereof

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Effect test

Embodiment 1

[0047] Embodiment 1: Preparation of platinum-based single-atom nanozyme

[0048] (1) 0.2g cisplatin (cis-[PtCl 2 (NH 3 ) 2 ]) and 7 mL of 30% hydrogen peroxide (H 2 o 2 ) into a round-bottomed flask with 5mL of ultrapure water, place the round-bottomed flask in a constant temperature water bath, and stir for 1 hour at a speed of 600r / min at 50°C to obtain a yellow solution. After crystallization, suction filtration, washing and drying, powder A was obtained;

[0049] (2) Weigh 0.2g of powder A and dissolve it in 5mL HCl (10M), put it in a constant temperature water bath, stir at 50°C for 1 hour at a speed of 400r / min, and then stir overnight at room temperature to obtain a yellow-green solution II;

[0050] (3) Add 25mL of ultrapure water to the yellow-green solution II, then weigh 20mmol 3,4-diaminopyridine (0.13g) and add it, put the yellow-green solution II in an ultrasonic disperser, under the condition of an ultrasonic frequency of 75kHz Ultrasonic dissolution, and...

Embodiment 2

[0053] Embodiment 2: Preparation of platinum-based single-atom nanozyme

[0054] (1) 0.4g cisplatin (cis-[PtCl 2 (NH 3 ) 2 ]) and 14 mL of 30% hydrogen peroxide (H 2 o 2 ) into a round-bottomed flask with 10 mL of ultrapure water, placed the round-bottomed flask in a constant temperature water bath, stirred at a speed of 800 r / min, and 60°C for 1 hour to obtain a yellow solution. After crystallization, suction filtration, washing and drying, powder A was obtained;

[0055] (2) Weigh 0.2g of powder A and dissolve it in 5mL HCl (10M), put it in a constant temperature water bath, stir at 50°C for 1 hour at a speed of 600r / min, and then stir overnight at room temperature to obtain a yellow-green solution II;

[0056] (3) Add 25mL of ultrapure water to the yellow-green solution II, then weigh 20mmol 3,4-diaminopyridine (0.13g) and add it, put the yellow-green solution II in an ultrasonic disperser, under the condition of an ultrasonic frequency of 55kHz Ultrasonic dissolutio...

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Abstract

The invention discloses a platinum-based monatomic nano-enzyme for combined treatment of tumors and a preparation method thereof, cis-platinum and 3, 4-diaminopyridine are used as precursors, and a platinum (IV)-based monatomic nano-enzyme drug is prepared through oxidative polymerization reaction. Compared with the prior art, the platinum (IV)-based monatomic nano-enzyme medicine prepared by the invention has both catalase-like and peroxidase-like activities, can relieve hypoxia of tumors to a great extent, consumes over-expressed glutathione in the tumors, and can promote generation of free radicals in tumor cells, reduce toxic and side effects and improve the radiotherapy treatment effect. The nano-enzyme has strong absorption in the whole near-infrared region, and can absorb 808nm laser and convert the laser into high-energy heat as a photothermal conversion agent, so that the lethality to tumor cells is greatly improved, and photothermal therapy is realized, and therefore, the thermotherapy and radiotherapy functions of the platinum (IV)-based monatomic nano-enzyme drug synergistically have a relatively strong killing effect on the tumor cells.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a platinum-based single-atom nanozyme for combined treatment of tumors and a preparation method thereof. Background technique [0002] As a disease with high mortality rate and difficult to cure, cancer has always caused extreme troubles to people's lives. According to the data from the 2015 World Cancer Report, global cancer cases have been showing rapid growth. In the past 20 years, the incidence of cancer in my country has shown a trend of younger age, morbidity and mortality. Thousands of cases. At present, people's treatment methods for cancer mainly include surgery, radiation therapy and chemotherapy. However, due to the large side effects of these treatment methods, it is easy to lead to adverse consequences, so it is difficult to meet the clinical needs. Therefore, in order to effectively treat cancer, people began to look for some nano-drugs with simp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/243A61K9/14A61P35/00
CPCA61K41/0052A61K33/243A61K9/14A61P35/00A61K2300/00
Inventor 雍媛徐琦琦张月通
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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