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Single light-activated nano particle and preparation method and application thereof

A nanoparticle, light-activated technology, applied in the field of medicine, can solve the problems of limited effect and need of combination therapy

Active Publication Date: 2019-10-08
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the absorption wavelength of the above-mentioned photosensitizer can match the absorption wavelength of general photothermal preparations, which solves the problem of needing dual lasers, the final combination therapy effect is still limited due to the severe oxygen dependence in PDT treatment.

Method used

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  • Single light-activated nano particle and preparation method and application thereof
  • Single light-activated nano particle and preparation method and application thereof
  • Single light-activated nano particle and preparation method and application thereof

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preparation example Construction

[0036] The present invention also provides a method for preparing single light-activated nanoparticles described in the above technical solution, comprising the following steps:

[0037] Provide hollow bismuth selenide nanoparticles;

[0038] The hollow bismuth selenide nanoparticle, phase change material, free radical initiator and solvent are mixed, and a loading reaction is carried out to obtain a single light-activated nanoparticle.

[0039] The invention provides hollow bismuth selenide nanoparticles. In the present invention, the method for preparing hollow bismuth selenide nanoparticles preferably includes the following steps: providing porous bismuth oxide nanoparticles, and preparing hollow bismuth selenide nanoparticles by using the porous bismuth oxide nanoparticles as templates.

[0040] In the present invention, the preparation method of the porous bismuth oxide nanoparticles preferably includes the following steps: mixing a bismuth salt, an acidic solution, an a...

Embodiment 1

[0052] (1) After mixing bismuth nitrate pentahydrate (0.485g, 1.19mmol) and nitric acid aqueous solution (13mL, 1mol / L), sodium hydroxide (0.144g, 3.6mmol), PVP (0.6g, Mw=10000 ) and ethylene glycol (57mL), stirred at 500rpm until the raw materials were completely dissolved, then transferred the resulting reaction solution to a stainless steel reactor, reacted at 150°C for 3h, cooled the resulting system to room temperature and centrifuged (10000r / min, 15min), the resulting solid material was washed 4 times, and dried in a vacuum oven for 48h to obtain porous bismuth oxide nanoparticles;

[0053] (2) Dissolve sodium selenite (0.0432g, 0.25mmol), ascorbic acid (0.4g, 2.27mmol) in deionized water (30mL), add porous bismuth oxide nanoparticle aqueous solution (0.9mL, 0.1mmol / L) , mixed evenly, transferred to the reaction kettle, reacted at 150°C for 12h, cooled the obtained system to room temperature and then centrifuged (10000r / min, 15min), washed the obtained solid material 4 ...

Embodiment 2

[0060] Prepare Bi according to the method of embodiment 1 2 Se 3 @AIPH nanoparticle, the difference from Example 1 is that sodium hydroxide is replaced by urea (0.213g, 3.55mmol) in step (1);

[0061] Measured by thermogravimetric analysis and UV-visible spectrophotometer, the Bi prepared in this embodiment 2 Se 3 The total loading of @AIPH nanoparticles lauric acid and AIPH was 17.5%, and the loading of AIPH was 11.7%.

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Abstract

The invention provides a single light-activated nano particle and a preparation method and application thereof, and belongs to the technical field of medicine. The single light-activated nano particlecomprises a hollow bismuth selenide nano particle, a phase-change material and a radical initiator, wherein the phase-change material and the radical initiator are loaded in the hollow bismuth selenide nano particle. The single light-activated nano particle is in laser radiation, absorbed light energy is converted to hyperthermia, cancer cells are directly killed, the phase-change material further can be prompted to melt, so that the radical initiator is released and split, generated free radical can cause cell membrane lipid peroxidation, glutathione is consumed, DNA is damaged, and thus thecancer cells are removed further. By detecting in vitro cytotoxicity and in vivo anti-cancer function, it is proved that the single light-activated nano particle has superior tumor killing capacity,and efficient photo-thermal and photodynamic combined therapy is realized through the hyperthermia and hyperthermia cascade activated free radical.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a single light-activated nanoparticle and its preparation method and application. Background technique [0002] Malignant tumors are one of the killers of human health. Traditional therapies have poor specificity and strong side effects. Light therapy is a method of using sunlight or artificial light (infrared, ultraviolet, visible light, laser) to prevent and treat diseases and promote the recovery of the body. Phototherapy has attracted extensive attention in the treatment of tumors due to its good spatiotemporal precision and non-invasiveness. Among them, photothermal therapy is to use materials with high photothermal conversion efficiency, inject them into the human body, use targeted recognition technology to gather near the tumor tissue, and irradiate them with an external light source (usually near-infrared light). A treatment that converts light energy into heat to kil...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61P35/00
CPCA61K9/51A61K41/0052A61K41/0057A61P35/00A61K2300/00
Inventor 袁直李晓敏
Owner NANKAI UNIV
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