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Multi-intelligence responsiveness microcapsule as well as application and preparation method thereof

A microcapsule and responsive technology, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of early release of drugs, lack of effective control of drug release, and inability of photothermal therapy Meet the clinical use requirements and other issues, achieve excellent temperature response and good biocompatibility

Inactive Publication Date: 2018-04-20
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although remarkable progress has been made in the field of smart responsive materials, it is still a challenge to make small responsive groups produce large phase transitions in a cumulative manner.
Furthermore, obtaining an aggregated system capable of producing response behaviors to multiple stimuli in a controllable and predictable manner remains a great challenge.
[0006] At present, the research on multifunctional materials integrating diagnosis and treatment continues to deepen, but there are still many problems to be solved urgently. For example, a single photothermal therapy cannot meet the clinical application requirements. The drug in the carrier is easy to release early, lacks effective control of drug release, and cannot achieve a synergistic therapeutic effect

Method used

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  • Multi-intelligence responsiveness microcapsule as well as application and preparation method thereof
  • Multi-intelligence responsiveness microcapsule as well as application and preparation method thereof
  • Multi-intelligence responsiveness microcapsule as well as application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Preparation of ferric oxide (Fe 3 o 4 )

[0048] Weigh ferrous sulfate (FeSO 4 ) 5 g was dissolved in 30 mL of distilled water, after dissolving, weighed ferric chloride (FeCl 3 ) 6 g in a constant temperature water bath at 30 ℃; after 30 min, warm up to 70 ℃ and slowly add 20 mL of ammonia water (NH 3 •H2O) and continue to stir; after 60 min, add 2 g of sodium citrate and continue to stir for 90 min, wash with distilled water 3 to 4 times to obtain ferric oxide solution.

[0049] (2) Preparation of aliphatic polyamine polyurethane (PUA)

[0050] The preparation process of aliphatic polyamine polyurethane (PUA) is as follows: figure 1 As shown, it is divided into two steps A and B.

[0051] Step A is to prepare aziridine. Specifically, dilute 40 g of ethanolamine and 37 mL of concentrated sulfuric acid with 20 g and 18.5 mL of water in a water bath at 0 °C, slowly add the ethanolamine solution dropwise to the concentrated sulfuric acid solution, and stir evenl...

Embodiment 2

[0065] The difference between this example and Example 1 is that in step (3), the calcium carbonate microspheres used as template particles are dispersed in the PUA solution, stirred for 10 min, and washed once by centrifugation at 3000 rpm; Add 0.5 mg / mL ferric oxide (Fe 3 o 4 ) solution, stirred for 15 min, and centrifuged at 3000 rpm to wash once. The stirring time after placing the obtained microsphere solution in 0.1 mol / L disodium edetate solution was 15 minutes.

Embodiment 3

[0067] The difference between this example and Example 1 is that in step (3), the calcium carbonate microspheres used as template particles were dispersed in the PUA solution and stirred for 20 min; 0.5 mg / mL was added to the washed suspension Ferric oxide (Fe 3 o 4 ) The stirring time after the solution was 20 min. The stirring time after placing the obtained microsphere solution in 0.1 mol / L disodium edetate solution was 45 minutes. The adsorption time in the step (4) is 10 hours.

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Abstract

The invention discloses a multi-intelligence responsiveness microcapsule. The multi-intelligence responsiveness microcapsule is prepared from aliphatic polyamine polyurethane and ferroferric oxide, wherein each of the aliphatic polyamine polyurethane and the ferroferric oxide is of a laminated structure and a plurality of layers of the aliphatic polyamine polyurethane and the ferroferric oxide arearranged; the aliphatic polyamine polyurethane layers and the ferroferric oxide layers are alternately assembled together layer by layer to form the aliphatic polyamine polyurethane / ferroferric oxideintelligence response hollow microcapsule; the surface of the microcapsule is modified by an anti-tumor hydrophilic drug. The invention further discloses application of the microcapsule serving as acarrier for delayed release of the drug, and a preparation method of the microcapsule. The multi-intelligence response microcapsule is prepared by utilizing a layer-to-layer self-assembling method; the method is simple and convenient and low cost; the multi-intelligence response type microcapsule has excellent multi-response performance including pH (Potential of Hydrogen), temperature, near infrared, magnetic response and the like and good biocompatibility; a cancer treatment drug doxorubicin hydrochloride is modified on the surface of the microcapsule so that the target property and the utilization rate of the drug are enhanced; the multi-intelligence responsiveness microcapsule has a good application prospect in the field of controlled release of the multi-intelligence response drugs.

Description

technical field [0001] The invention relates to the technical field of targeted drug delivery, in particular to a microcapsule with multiple responses and a preparation method thereof. Background technique [0002] Therapeutic drugs used in the human body, especially anti-tumor drugs, usually have strong toxic and side effects on normal tissues and cells. Targeting the drug to the lesion and releasing it slowly can not only improve drug utilization and reduce drug dosage, Moreover, it can reduce the distribution of drugs in normal tissues, and effectively reduce or even eliminate the toxic and side effects of drugs on other normal parts. [0003] Targeted drug delivery is of great significance to reduce the distribution and release of drugs in normal tissues, so targeted drug release carriers have attracted great interest due to their particularity in the field of biomedicine. [0004] As an important part of the targeted drug delivery system, the selection and intelligent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/69A61K47/52A61K47/59A61K31/704A61P35/00
CPCA61K9/0009A61K31/704A61K41/00A61K41/0052
Inventor 杨柳石军曹少魁
Owner ZHENGZHOU UNIV
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