Preparation method of L-polylactide-modified MgO nano-rod composite material

A technology of L-polylactic acid and composite material, which is applied in the field of preparation of L-polylactic acid-modified MgO nanorod composite material, can solve the problems of limited wide application, rapid degradation speed and strength loss, and inability to achieve simple and easy process. effect of implementation

Inactive Publication Date: 2014-05-28
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
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Problems solved by technology

However, the defects exposed in its use limit its wide application
The main problems are: 1) The degradation speed and strength loss are too fast at the initial stage of implantation, and the degradation process is uncontrollable due to the autocatalytic effect, and it cannot match the growth of new bone; 2) The degradation intermediate lactic acid strongly reduces the pH value of body fluid, making the The environment around the implant is obviously acidic; 3) The enzymatic degradation rate of lactic acid intermediates is too slow, and it can be completely degraded in 2-3 years
[0006] In order to achieve the purpose of regulating the degradation of PLLA and significantly improving its mechanical properties, the present invention proposes to modify MgO nanorods with carboxyl-rich degradable organic substances (random copolymers of DL-malic acid and low-molecular-weight polylactic acid), and combine them with PLLA blending, a method for preparing PLLA / g-MgO-r composites by in-situ bonding, has not been reported publicly at home and abroad

Method used

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  • Preparation method of L-polylactide-modified MgO nano-rod composite material

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Effect test

Embodiment 1

[0030] A preparation method of L-polylactic acid-modified MgO nanorod composite material, comprising the steps of:

[0031] 1) Preparation of MgO nanorods

[0032] MgC1 2 ·6H 2 O was dissolved in deionized water to obtain a magnesium chloride solution with a concentration of 0.6g / ml. After stirring at 25°C for 20 minutes, add 0.45g of MgO nanorods with a diameter of less than 50nm and an aspect ratio greater than 10, and continue stirring at 45°C. 21h, then centrifuged, washed with water four times, finally washed with ethanol, centrifuged to obtain oxychloride cement [Mg x (OH) y Cl z . n h 2 O] precipitate, after above-mentioned precipitate is washed with water, ethanol successively, join concentration and be in the 4M NaOH solution, oxychloride cement [Mg x (OH) y Cl z . n h 2 O] The amount ratio of the precipitate to the NaOH solution is 75g: 100ml, stirred and reacted at 45°C for 3h, then washed with water and ethanol in turn, dried, and calcined at 600°C...

Embodiment 2

[0039] A preparation method of L-polylactic acid-modified MgO nanorod composite material, comprising the steps of:

[0040] 1) The preparation of MgO nanorods is the same as in Example 1;

[0041] 2) Surface modification of MgO nanorods

[0042] According to the mass ratio of 1:9.6:1, DL-malic acid, polylactic acid with a molecular weight of 500-1000, and MgO nanorods were mixed in a single-necked flask, and the magnetic stirring reaction was carried out at a vacuum degree of 0.05MP and a temperature of 145°C for 8.5 h, after washing the obtained product three times with ethyl acetate, vacuum drying at 45° C. for 20 min to obtain powdery modified MgO nanorods;

[0043] 3) The preparation of the composite material is the same as in Example 1, and a film-like L-LA-modified MgO nanorod composite material with a concentration of 0.5 wt% can be obtained.

[0044] After cutting the prepared film-like composite material into pieces, it is injection-molded by an injection molding ma...

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Abstract

The invention discloses a preparation method of an L-polylactide-modified MgO nano-rod composite material. The preparation method comprises the following steps: 1) preparing an MgO nano-rod; 2) performing surface modification on the MgO nano-rod; 3) preparing the L-polylactide-modified MgO nano-rod composite material. The invention has the advantages that the preparation method is simple in technology and easy to implement; the prepared composite material can be used for preparing fracture inner fixing products including bone nails, bone lamellae, and cancellous bone screws; the osteogenic capability when the material is planted into an animal body is obviously better than that of PLLA; the preparation method adopts the MgO nano-rod as a reinforced bone frame, so that the improvement on composite material mechanic performance is more effective than that of MgO-NPs grains since crystal whisker distributed in the polymer matrix can improve the strength and plasticity of the composite material through four manners, namely load transmission, crack bridging, crack deflection, and extraction effect.

Description

technical field [0001] The invention belongs to the technical field of organic / inorganic nanocomposite materials, in particular to a preparation method of L-polylactic acid-modified MgO nanorod composite material. Background technique [0002] With the aggravation of the population aging trend and the increasing incidence of bone trauma caused by industry and traffic, there is a huge clinical demand for new bone repair materials. However, currently used internal fixation materials for fractures are mainly bioinert stainless steel and titanium alloys, which are prone to osteolysis due to the stress shielding effect, and must be removed after a second operation after the fracture has healed. Complicated bone trauma, osteomyelitis, and large-sized bone defects left after bone tumor surgery also require a large number of bone grafts to repair, while autologous bone or allogeneic bone grafts are difficult to meet the needs due to many objective factors, and are filled with degra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L67/04C08K9/04C08K7/00C08K3/22A61L31/14
Inventor 陈民芳曹秀香刘贝王亮
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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