Preparation method of nano antibacterial coating based on molybdenum disulfide and photosensitizer near-infrared optical response

A near-infrared photoresponse and antibacterial coating technology, which is applied in coatings, metal material coating technology, pharmaceutical formulations, etc., can solve the problem of poor biocompatibility of implants, no antibacterial effect, and aggravated secondary infections. problem, to achieve the effect of improving biocompatibility, making the preparation method simple and easy, and helping the body repair

Active Publication Date: 2018-08-14
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing medical implants have no antibacterial effect, or the effect is not ideal, and the phenomenon of secondary infection is prone to occur. The bacterial group at the infection site forms a layer of bacterial film, which is highly resistant to drugs and is not easy to remove. At the same time, the biocompatibility of the implant Sexuality is not optimistic, which increases the chance of secondary infection

Method used

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  • Preparation method of nano antibacterial coating based on molybdenum disulfide and photosensitizer near-infrared optical response
  • Preparation method of nano antibacterial coating based on molybdenum disulfide and photosensitizer near-infrared optical response
  • Preparation method of nano antibacterial coating based on molybdenum disulfide and photosensitizer near-infrared optical response

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Embodiment 1

[0033] (1) Step 1: Grind the titanium alloy disc (diameter 6mm, thickness 2.5mm) step by step to 800 mesh with silicon carbide sandpaper, then ultrasonically clean it in ethanol and deionized water, dry and seal the cleaned titanium sheet for later use . Weigh 10mg of sodium molybdate dihydrate and 20mg of thioacetamide respectively and dissolve them in 20ml of deionized water. Stir continuously with a magnetic stirrer at medium speed for 30min to fully mix to obtain a clear and transparent liquid. Drain with a glass rod and transfer to a 100ml reaction kettle , Take out the previously saved titanium alloy discs and put them into the reactor one by one, so that the titanium alloy discs are evenly distributed at the bottom of the reactor, and then put the reactor into an oven to react at 200 ° C for 24 hours. After 24 hours, take out the titanium alloy disc in the reaction kettle, rinse it repeatedly with deionized water and absolute ethanol, and dry it in vacuum, then put the ...

Embodiment 2

[0037](1) Step 1: Grind the titanium alloy disc (diameter 6mm, thickness 2.5mm) step by step to 800 mesh with silicon carbide sandpaper, then ultrasonically clean it in ethanol and deionized water, dry and seal the cleaned titanium sheet for later use . Weigh 5mg of sodium molybdate dihydrate and 10mg of thioacetamide and dissolve them in 20ml of deionized water, stir continuously at medium speed with a magnetic stirrer for 30min to fully mix to obtain a clear and transparent liquid, drain it with a glass rod and transfer it to a 100ml reaction kettle , Take out the previously saved titanium alloy discs and put them into the reactor one by one, so that the titanium alloy discs are evenly distributed at the bottom of the reactor, and then put the reactor into an oven to react at 200 ° C for 24 hours. After 24 hours, take out the titanium alloy disc in the reaction kettle, rinse it repeatedly with deionized water and absolute ethanol, and dry it in vacuum, then put the dried sam...

Embodiment 3

[0041] (1) Step 1: Grind the titanium alloy disc (diameter 6mm, thickness 2.5mm) step by step to 800 mesh with silicon carbide sandpaper, then ultrasonically clean it in ethanol and deionized water, dry and seal the cleaned titanium sheet for later use . Weigh 20mg of sodium molybdate dihydrate and 40mg of thioacetamide respectively and dissolve them in 20ml of deionized water. Stir continuously with a magnetic stirrer at a medium speed for 30min to fully mix to obtain a clear and transparent liquid. Drain with a glass rod and transfer to a 100ml reaction kettle , Take out the previously saved titanium alloy discs and put them into the reactor one by one, so that the titanium alloy discs are evenly distributed at the bottom of the reactor, and then put the reactor into an oven to react at 200 ° C for 24 hours. After 24 hours, take out the titanium alloy disc in the reaction kettle, rinse it repeatedly with deionized water and absolute ethanol, and dry it in vacuum, then put th...

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Abstract

The invention discloses a preparation method of a nano antibacterial coating based on molybdenum disulfide and photosensitizer near-infrared optical response. The preparation method specifically comprises the following steps: polishing a titanium sheet to remove dirt; preparing a molybdenum disulfide nano coating with near-infrared photo-thermal antibacterial performance by applying a photo-thermal method; dropwise adding a photosensitizer IR780 to enable the photosensitivity of the IR780 and the photo-thermal performance of molybdenum disulfide to generate a cooperative antibacterial effect;covering a titanium surface with the photosensitizer IR780 through a self-polymerized membrane by utilizing dopamine and grafting a polypeptide RGDC to obtain the coating. The coating has relatively good biocompatibility and osteogenesis; the method has a simple preparation process and low cost; the prepared coating can be used for extremely improving the antibacterial performance of implants in bodies, damages caused by secondary pollution can be reduced under the condition of short-time near-infrared light illumination and organisms are repaired; harms caused by the fact that antibiotics arerepeatedly used for resisting bacteria are reduced; the polypeptide RGDC is used so that the biocompatibility of the implants is better and the occurrence of infection is reduced.

Description

technical field [0001] The invention relates to the technical fields of material science and nanomaterials, in particular to a method for preparing a near-infrared light-responsive nano-antibacterial coating based on molybdenum disulfide and a photosensitizer. Background technique [0002] Transition metal disulfides (TMDs) are a class of alloy semiconductors with a typical layered structure, which have been used in many fields such as memory devices, photodetectors, lithium batteries, hydrogen production catalysts, DNA detection, and transistors in recent years. Moreover, TMD materials have wide and strong near-infrared absorption and good biocompatibility, so they have great potential in the field of photothermal therapy. As one of the TMD materials, molybdenum disulfide (MoS2) has low cost, low toxicity and Advantages such as high photothermal conversion efficiency play an important role in nanobiomedicine. [0003] The preparation of nano-molybdenum disulfide by hydroth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54A61L27/30A61L27/28A61L27/06C23C18/12
CPCA61L27/06A61L27/28A61L27/306A61L27/34A61L27/54A61L2300/45A61L2300/604A61L2300/606A61L2400/12A61L2430/02C23C18/1204C23C18/1295
Inventor 吴水林冯梓洲刘想梅李朝阳朱胜利崔振铎杨贤金
Owner HUBEI UNIV
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