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Bone repair material able to guide bone tissue regeneration

A technology for bone tissue regeneration and bone repair, applied in the fields of medical science and prosthesis, can solve the problems of porosity and void size of artificial synthetic materials, and achieve the effect of guiding osteogenesis.

Inactive Publication Date: 2013-06-19
XIAN REJE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a bone repair material to overcome the deficiencies in the hardness, strength and plasticity of existing artificial synthetic materials, as well as the production difficulties of artificial synthetic materials in terms of porosity, void size, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take bioabsorbable polymer materials such as collagen, chitosan, and fibrin, and prepare a solution with an appropriate concentration of 0.05% (w / v) with 0.1% (v / v) acetic acid, and use NaHCO 3 After adjusting the pH value to neutral, add calcined bone meal with a diameter range of 0.1-2mm; 50°C water bath for 8 hours, centrifuge at 1500 rpm for 6 minutes, discard the supernatant, and take the precipitate; vacuum the precipitate and irradiate it under ultraviolet light for 30 Minutes, during which the particles were turned over several times; ethylene oxide was fumigated and sterilized to obtain bone repair materials.

Embodiment 2

[0021] Take bioabsorbable polymer materials such as collagen, chitin, calcium alginate, fibrin, and elastin, and use 0.1% (v / v) acetic acid to prepare a solution with an appropriate concentration of 0.05% (w / v), and use NaHCO 3 After adjusting the pH value to neutral, add calcined bone meal with a diameter of 0.1-2mm; bathe in water at 60°C for 6 hours, centrifuge at 1500 rpm for 6 minutes, discard the supernatant, and take the precipitate; vacuum dry the precipitate, and irradiate it under ultraviolet light for 45 Minutes, during which the particles were turned over several times; ethylene oxide was fumigated and sterilized to obtain bone repair materials.

Embodiment 3

[0023] Take bioabsorbable polymer materials such as collagen, hyaluronic acid, chondroitin sulfate, calcium alginate, and elastin, and prepare a 0.05% (w / v) solution with an appropriate concentration of 0.1% (v / v) acetic acid, and use NaHCO 3 After adjusting the pH value to neutral, add calcined bone meal with a diameter range of 0.1-2mm; 80°C water bath for 4 hours, centrifuge at 1500 rpm for 6 minutes, discard the supernatant, take the precipitate, vacuum-dry the precipitate, and irradiate for 60 minutes under ultraviolet light During the process, the particles were turned over several times; ethylene oxide was fumigated and sterilized to obtain bone repair materials.

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PUM

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Abstract

The invention discloses a bone repair material able to guide bone tissue regeneration. The material is a composition of calcined bone powder with different particle sizes and a bioabsorbable high polymer material. The bone repair material is characterized in that: the particle sizes of the calcined bone powder range from 0.1-2mm; and the bioabsorbable high polymer material is one or more of collagen, chitin, chitosan, hyaluronic acid, chondroitin sulfate, calcium alginate, fibrous protein, and elastin. The bone repair material provided in the invention has an obvious bone healing guiding effect and good biocompatibility. Also with certain hardness and strength, the bone repair material is easy to shape and has rich sources, thus solving the making problems of artificial synthetic materials in the aspects of porosity, pore traffic and pore size, etc.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a bone repair material capable of guiding bone tissue regeneration. Background technique [0002] With the progress of modernization and the improvement of living standards, the pace of life is gradually accelerating, and diseases causing bone defects are on the rise. Bone defects caused by various lesion treatments such as trauma, inflammation, and bone tumor removal are often encountered clinically. [0003] It has always been a difficult problem in the field of orthopedic repair that the bone defect cannot heal after reaching a certain area. Bone grafting is the most effective measure to treat bone defects. Research on bio-substitute materials for bone grafting has been a long-term key research topic in the Department of Orthopedics. For centuries, people have tried a variety of different repair materials. Using the principles of tissue engineering to ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/36A61L27/24A61L27/22A61L27/20
Inventor 孙叶芳
Owner XIAN REJE BIOLOGICAL TECH
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