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91results about How to "To achieve the purpose of treating diseases" patented technology

Chitosan-chitosan derivative nanosphere for loading indissoluble medicament, preparation method of nanosphere, and application of nanosphere serving as oral prepration

The invention provides a chitosan-chitosan derivative nanosphere product for loading an indissoluble medicament. The product has a porous structure with controllable aperture, thus being capable of controlling the medicament to be released relatively quickly and stably. When the nanosphere product is taken as an oral preparation, as a large number of positive charges exist on the surface of the nanosphere product, the adhesiveness and membrane permeability of the preparation on a small intestine part are improved greatly, and the oral bioavailability of the medicament is enhanced. Simultaneously, the product can be jointly loaded with medicaments with electronegativity or coupling targeting ligands to achieve the aim of coordinating administration or targeting administration. The chitosan-chitosan derivative nanosphere product not only can be used for improving the tolerance of a patient, but also has relatively low toxic and side effects. The invention also provides a preparation method of the chitosan-chitosan derivative nanosphere product for loading the indissoluble medicament. The grain size of the product prepared from the method is uniform. The preparation method is applicable to medicaments which are insoluble in water but soluble in fat, and can be used for controlling nanocrystallines of the indissoluble medicament to be uniformly distributed in the nanosphere in an in-situ crystallization way so as to improve the medicament loading efficiency.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Unguent for treating rheumatism bone pain and preparation method thereof

The invention provides unguent for treating rheumatism bone pain and a preparation method thereof. The unguent is characterized in that the unguent has the functions of dispelling wind, eliminating dampness, warming the channels, relieving the pain and inhibiting osteoproliferation and fibroplasias by adopting dog tibia, semen strychni, radix aconite preparata, radix aconite agrestis, rhizoma arisaematis and the like; the unguent has the function of recovering local myodynamia by adopting dragon blood, olibanum and radix saposhnikoviae; the pharmacological function can reach the focus to treat a disease by adopting azone, borneol and cortex cinnamomi. According to the unguent for treating the rheumatism bone pain, disclosed by the invention, traditional Chinese medicine is extracted by using alcohol and is decocted and concentrated by water, and the unguent is prepared by combining the traditional Chinese medicine with traditional unguent matrix, so that the quality of raw material components is ensured, the components of medicine are enabled not to damage, the pharmacological function is increased, and clinic application verifies that the unguent can be used for effectively treating osteoproliferation and herniated disc and completely and rapidly treating the neck shoulder backleg pain caused by wind cold dampness.
Owner:鲍泽全

Externally applied traditional Chinese medicine powder for treating lumbar disc herniation

The invention discloses externally applied traditional Chinese medicine powder for treating lumbar disc herniation. The powder comprises the following five traditional Chinese medicines: obtuseleaf erycibe stem, Chinese clematis root, bark of girald daphne, draconis resin and borneol. The powder has few compatible medicines, is simple and convenient to operate and has quick curative effects. Externally mixed and applied, the powder stops pains quickly and has an instant effect of eliminating lumbar disc symptoms. Chinese clematis root is acrid in taste, is divergent, is damp, promotes diuresis, can stimulate the twelve meridians, can not only expel the exterior wind but also remove interior dampness, stimulates meridians and activates collaterals, can carry out guide and dispersing, is an important medicine for gout and is suitable for wind-cold-dampness arthralgia, inflexibility of joints, muscular paralysis, aches of muscles and bones and gastral cavity separated phlegm and retained fluid. The powder has the advantages that the medicine is absorbed via skins and achieves the aim of treating diseases and is not absorbed via gastrointestinal tracts, so the medicine does not have the side effects caused by administration, does not harm qi and blood of spleens and stomachs and can be used by all the persons as long as the skins are not allergic to the medicine during clinical application.
Owner:朱军

Chinese medicinal externally-used patch for treating cough and asthma due to accumulation of phlegm and heat in lung and preparation method thereof

The invention discloses a Chinese medicinal externally-used patch for treating cough and asthma due to the accumulation of phlegm and heat in the lung and a preparation method thereof. The Chinese medicinal externally-used patch is prepared from the following raw materials in parts by weight: 10-15 parts of baikal skullcap roots, 20-25 parts of mongolian dandelion herb, 20-25 parts of cape jasmine fruits, 5-10 parts of peppermint, 10-15 parts of rhubarb, 10-15 parts of red paeony roots, 20-25 parts of arisaema cum bile and 20-25 parts of raw ephedra herb. The preparation method of the Chinese medicinal externally-used patch comprises the following steps: smashing the raw materials into powder, sieving the powder, adding fresh ginger juice and stirring uniformly to obtain a thick paste. The Chinese medicinal externally-used patch can be pasted on an acupuncture point or irradiated on skin. The Chinese medicinal herbs in the formula are combined reasonably, so that the Chinese medicinal externally-used patch has the functions of dissipating heat, freeing the lung, clearing away heat, eliminating phlegm and relieving cough and asthma, can be used for improving the symptoms of cough and asthma with phlegm, is superior to the single western medicine in treatment effect, has no obvious side and toxic effects, is easy to prepare, is low in cost and can be easily accepted by patients.
Owner:福建省漳州市中医院

Gel patch with heat clearing, swelling removing and pain stopping functions and preparation method of gel patch

The invention relates to a gel patch with heat clearing, swelling removing and pain stopping functions and a preparation method of the gel patch. According to the method, amur corktree barks, Chinesegoldthread rhizomes, medicinal rhubarb roots and rhizomes, raw gypsum, purslane herbs, herba siegesbeckiae, lobedleaf pharbitis seeds, fourstamen stephania roots, calabash shells, Indian bread exodermis, Chinese clematis roots and yanhusuo rhizomes are extracted by ethyl alcohol or water, extracts are dried to obtain powdery alcohol extracts or water extracts, or original medicinal materials are directly grinded into powder and screened to obtain fine medicinal powder, the powdery alcohol extracts, the water extracts and /or the fine medicinal powder, borneol, mirabilite and substrates are crosslinked to prepare the gel patch, and the substrates comprise polyoxyethylene hydrogenated castor oil, sodium polyacrylate, dihydroxyaluminum aminoacetate, tartaric acid, glycerin, povidone and oilyazone. The prepared gel patch can remarkably relieve arthritis and has good functions of clearing heat and removing swelling. Compared with a traditional preparation, the gel patch has the advantagesthat medicine using modes are diverse, drug loading capacity is high, moist maintenance performances are good, residues are omitted, gastrointestinal reaction is omitted, using and carrying are convenient, and compliance of a patient can be remarkably improved.
Owner:上海市光华中西医结合医院

Thermosensitive gel and preparation method thereof

The invention discloses thermosensitive gel and a preparation method thereof. Albiflorin with antidepressant activity is carried into nanogel particles to serve as drug-release reservoirs, and throughthe interaction between alginic acid and poloxamer molecular chain segments, the albiflorin-zinc alginate thermosensitive self-assembled gel is constructed. According to the albiflorin controlled-release antidepressant thermosensitive gel prepared through the method, the mode of drug administration through the nose is adopted, and thus the gel can adhere to the surface of the nasal mucosa at thebody temperature to continuously release a drug; the albiflorin directly enters the brain through an olfactory region, is not limited by blood-brain barriers, and can quickly take effect to treat depression; pharmacodynamic experiments prove that an albiflorin thermosensitive self-assembled gel preparation is superior to other drugs or preparation formulations in the aspect of quickly taking effect to resist depression; and the drug delivery and absorption efficiency is improved, the onset time is shortened, a more suitable and more effective novel preparation formulation is provided for treating depression through the albiflorin, and the application range of the thermosensitive gel is enlarged.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE

Erythrocyte membrane surface modification gene delivery system as well as preparation method and application

The invention discloses an erythrocyte membrane surface modification gene delivery system as well as a preparation method and an application. The preparation method comprises the following steps: I, preparing blood, and removing plasma and a leucocytes layer, so that a sample 1 is obtained; cleaning the sample 1: adding the sample 1 to a 0.25*PBS buffer solution, keeping an obtained solution in anice bath so that erythrocyte membranes get cracked and heme is released, implementing centrifuging and collecting a sample 2; implementing cleaning and centrifuging, so that a sample 3 is obtained; adding the sample 3 to a PBS buffer solution, and implementing ultrasonic processing, so that a sample 4 is obtained; reciprocally extruding a nano polycarbonate thin film via a liposome extrusion apparatus, repeatedly conducting the operation of extruding, and collecting erythrocyte membrane vesicle liquid as a sample 5; and implementing ultrasonic processing, so as to obtain nano erythrocyte membrane liquid as a sample 6; II, preparing a gene compound; and III, dropping the sample 6 into the gene compound, so that the erythrocyte membrane surface modification gene delivery system is obtained.The system provided by the invention is high in transfer efficiency and low in cytotoxicity; the system is good in bio-compatibility, and the system, which is stable in blood, is prevented from beingrapidly removed in vivo; and in-vivo circulating time is greatly prolonged, so as to bring about benefits for gene delivery and expression.
Owner:TIANJIN UNIV

Traditional Chinese medicine preparation for treating chronic prostatitis

The invention discloses a traditional Chinese medicine preparation for treating chronic prostatitis. The traditional Chinese medicine preparation comprises the following components in parts by weight: 8-30 parts of cortex phellodendri, 8-30 parts of glabrous greenbrier rhizome, 8-30 parts of semen vaccariae, 10-50 parts of flos chrysanthemi indici, 8-30 parts of achyranthes aspera, 5-20 parts of semen persicae, 5-20 parts of flos carthami, 8-30 parts of radix salviae miltiorrhizae, 10-40 parts of angelica sinensis, 10-40 parts of radix rehmanniae recen, 8-30 parts of radix dipsaci, 10-40 parts of astragalus, 5-20 parts of rhizoma atractylodis macrocephalae and 10-40 parts of herba epimedii. The traditional Chinese medicine preparation can increase the prostate blood flow volume, reduce the blood viscosity, improve microcirculation in prostate tissues, inhibit inflammatory response and growth of pathogenic microorganisms and eliminate clinical symptoms of chronic prostatitis through the methods of clearing heat and promoting diuresis, activating blood circulation to dissipate blood stasis and reinforcing kidney to nourish qi, has the advantages of definite curative effect, relatively short treatment course, high cure rate, low recurrence rate, little side effects and the like, can also serve as an auxiliary medicine for acute prostatitis and is suitable for treating various prostatitis.
Owner:THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV

Preparation method and application of electropositive polymer fluorescent carbon quantum dots with gene vector function

The invention discloses a preparation method and application of electropositive polymer fluorescent carbon quantum dots with a gene vector function, and relates to the preparation method and application of the fluorescent carbon quantum dots. The invention aims at solving the problems of heavy metal ions, low yield of quanta and unstable fluorescent property in the existing semiconductor fluorescent nano particles. The preparation method comprises the following steps: 1, adding organic acid and a cationic high molecular polymer, performing ultrasonic dissolution at room temperature to form a mixed solution; 2, charging the mixed solution into a reaction kettle, and heating for reaction until the color of the mixed solution turns into black brown; 3, adding water with the volume being 2 times of that of the black brown solution into the black brown solution, removing solid by centrifuging, and reserving the solution; and 4, adding deionized water to the solution, uniformly mixing and then recentrifuging the solution, removing solid, and then performing dialyses treatment to obtain the water solution of polymer carbon quantum dots. The polymer fluorescent carbon quantum dots synthesized by the method have superior fluorescent stability and high yield of quanta which is over 60%. The preparation method is used for preparing the polymer fluorescent carbon quantum dots.
Owner:CHANGCHUN UNIV OF TECH

Herb-partitioned navel-fumigating traditional Chinese medicine composition for treating stomachache of deficient coldness pattern

The invention provides an herb-partitioned navel-fumigating traditional Chinese medicine composition for treating stomachache of deficient coldness pattern. The herb-partitioned navel-fumigating traditional Chinese medicine composition comprises trogopterus dung, fennel, clove, ligusticum wallichii, radix paeoniae alba, Chinese eaglewood and pericarpium zanthoxyli. The traditional Chinese medicine composition can effectively solve symptoms such as stomachache, stomach distension, loose stool, poor appetite, intolerance of cold and cold extremities, tiredness and weakness and fatigue and disinclination to talk caused by stomachache of the deficient coldness pattern. Curative methods of external application of traditional Chinese medicine and herb-partitioned navel fumigation are adopted during treatment, simpleness, convenience, effectiveness, cheapness and quickness are achieved, the navel (Shenque acupoint) and the master center of the meridians and collaterals are fully used for gathering channel qi and have the characteristics of being thin in skin, high in sensitivity, containing a large quantity of capillaries, strong in permeability, fast in absorptivity and the like, the five-in-one function of acupoint features, moxa wool, herb, fire, TDF baking lamps and the like is given into play, absorption of four properties and five tastes of external application medicine is quickened, the side effect of gastrointestinal tracts is reduced, and the herb-partitioned navel-fumigating traditional Chinese medicine composition has the advantages of being fast in taking effect, accurate in curative effect and painlessness; the herb-partitioned navel-fumigating traditional Chinese medicine composition achieves good result in clinical application, and the effective rate is 93.33%.
Owner:THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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