Gel patch with heat clearing, swelling removing and pain stopping functions and preparation method of gel patch

A heat-clearing, swelling-reducing and gel technology, which is applied in the direction of non-central analgesics, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve problems such as easy to clog pores, difficult to quantify, and cumbersome cleaning , to achieve high patient compliance, relieve damp-heat-type arthritis, and low drug loss rate

Pending Publication Date: 2019-07-05
上海市光华中西医结合医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the clinical application of Xiaobi Ointment is limited by the dosage form. For example, Vaseline is easy to melt when heated, difficult to quantify, difficult to fix, easy to contaminate clothing and bedding, and affect patients' daily activities. To a certain extent, it is easy to clog the pores, and the cleaning is more cumbersome, and the patient's compliance is not high

Method used

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  • Gel patch with heat clearing, swelling removing and pain stopping functions and preparation method of gel patch
  • Gel patch with heat clearing, swelling removing and pain stopping functions and preparation method of gel patch
  • Gel patch with heat clearing, swelling removing and pain stopping functions and preparation method of gel patch

Examples

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preparation example Construction

[0054] The invention relates to a preparation method of a gel plaster for clearing away heat, reducing swelling and relieving pain, which comprises the following steps:

[0055] Step 1. Select the original medicinal materials, which include: 5-30 parts of Cortex Phellodendri, 2-20 parts of Coptidis Rhizoma, 5-30 parts of Rhubarb, 12-50 parts of Gypsum, 1-20 parts of Borneolum, 12-50 parts of Purslane, and 12-50 parts of Purslane. Grass 12-50 parts, black and white ugly 5-30 parts, Fangji 5-30 parts, gourd shell 5-30 parts, Poria cocos skin 5-30 parts, Glauber's salt 5-30 parts, Clematis 12-50 parts, Yuanhusuo 12-50 copies;

[0056] Step 2, processing of raw medicinal materials: extract raw medicinal materials that do not contain borneol and Glauber's salt with ethanol or water, and dry and grind the extract to obtain powdered alcohol extract or powdered water extract; or directly extract the Powder and sieve the original medicinal materials containing borneol and mirabilite t...

Embodiment 1

[0060] The traditional Chinese medicine preparation for clearing heat, reducing swelling and relieving pain provided in this example is an external ointment, which is a gel plaster with a drug loading of 20% alcohol extract, and is prepared as follows:

[0061] Prepare the raw medicinal materials according to the following quantities: 15 parts of Cortex Phellodendri, 10 parts of Coptidis Rhizoma, 15 parts of Rhubarb, 27 parts of Gypsum, 10 parts of Borneol, 31 parts of Purslane, 30 parts of Wexgrass, 12 parts of Black and White Chou, 13 parts of Fangji, gourd Shell 15 parts, Poria cocos skin 14 parts, Glauber's salt 15 parts, Clematis 30 parts, Yuan Hu Suo 29 parts.

[0062] Add 9 times of 85% ethanol to the raw medicinal materials that do not contain borneol and Glauber’s salt in the preparation, reflux and extract for 1.5 hours, filter with a suction filter bottle, add 9 times of 85% ethanol to the remaining medicinal residues, and add 9 times of 85% ethanol to reflux and ext...

Embodiment 2

[0065] The traditional Chinese medicine preparation for clearing heat, reducing swelling and relieving pain provided in this example is an external ointment, which is a gel plaster with a drug loading of 20% alcohol extract, and is prepared as follows:

[0066] Prepare the raw medicinal materials according to the following quantities: 15 parts of Cortex Phellodendri, 15 parts of Coptidis Rhizoma, 15 parts of Rhubarb, 30 parts of Gypsum, 1 part of Borneolum, 30 parts of Purslane, 30 parts of Wexgrass, 15 parts of Black and White Chou, 15 parts of Fangji, gourd Shell 15 parts, Poria cocos skin 15 parts, Glauber's salt 15 parts, Clematis 30 parts, Yuan Hu Suo 30 parts.

[0067] Add 10 times of 70% ethanol to the original medicinal materials that do not contain borneol and mirabilite in the preparation for reflux extraction for 1 hour, filter the filter bottle, add 8 times of 70% ethanol to the remaining medicinal residues for reflux extraction for 1 hour, combine the filtrates, an...

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Abstract

The invention relates to a gel patch with heat clearing, swelling removing and pain stopping functions and a preparation method of the gel patch. According to the method, amur corktree barks, Chinesegoldthread rhizomes, medicinal rhubarb roots and rhizomes, raw gypsum, purslane herbs, herba siegesbeckiae, lobedleaf pharbitis seeds, fourstamen stephania roots, calabash shells, Indian bread exodermis, Chinese clematis roots and yanhusuo rhizomes are extracted by ethyl alcohol or water, extracts are dried to obtain powdery alcohol extracts or water extracts, or original medicinal materials are directly grinded into powder and screened to obtain fine medicinal powder, the powdery alcohol extracts, the water extracts and /or the fine medicinal powder, borneol, mirabilite and substrates are crosslinked to prepare the gel patch, and the substrates comprise polyoxyethylene hydrogenated castor oil, sodium polyacrylate, dihydroxyaluminum aminoacetate, tartaric acid, glycerin, povidone and oilyazone. The prepared gel patch can remarkably relieve arthritis and has good functions of clearing heat and removing swelling. Compared with a traditional preparation, the gel patch has the advantagesthat medicine using modes are diverse, drug loading capacity is high, moist maintenance performances are good, residues are omitted, gastrointestinal reaction is omitted, using and carrying are convenient, and compliance of a patient can be remarkably improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a gel plaster for clearing heat, reducing swelling and relieving pain and a preparation method thereof. Background technique [0002] At present, what has a relatively excellent effect on clearing away heat, reducing swelling and relieving pain is a prescription of Xiaobi gel plaster, which is composed of Xishicao, Phellodendron, Purslane, Coptis chinensis, Fangji, Clematis, raw gypsum, rhubarb, Corydalis, and Petunias. , gourd shell, Poria cocos skin, Glauber's salt, borneol. [0003] In the prescription of the above-mentioned Xiaobi Gel Plaster, the three medicines of Herba chinensis, purslane, and Fangji are the king medicines, which can clear away heat and relieve fire, dredge the collaterals and relieve pain; Cortex Phellodendri, Coptidis Rhizome, Gypsum, Clematis, etc. are ministerial medicines, clearing away heat and purging Fire, detoxif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/70A61K47/32A61P29/00A61P19/02A61K33/06A61K33/04A61K31/045
CPCA61K9/7053A61K31/045A61K33/04A61K33/06A61K36/076A61K36/185A61K36/28A61K36/39A61K36/42A61K36/59A61K36/66A61K36/708A61K36/716A61K36/718A61K36/756A61K47/32A61K2236/333A61K2236/39A61K2236/51A61P19/02A61P29/00A61K2300/00
Inventor 何东仪秦亮甫林婷婷郭梦如丁琴姜婷
Owner 上海市光华中西医结合医院
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