Thermosensitive gel and preparation method thereof
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A temperature-sensitive gel agent and technology of temperature-sensitive gel, applied in the field of medicine, can solve the problems of poor application of depression treatment, slow onset of action, and large side effects
Active Publication Date: 2020-07-21
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
[0006] Currently clinically used antidepressant drugs have slow onset of action and large side effects, so they cannot be well applied to the treatment of depression
Method used
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Embodiment 1
[0091] Example 1 Preparation of paeonifloride-alginate nanogel
[0092] 1. Preparation of sodium alginate-water solution
[0093] Under the condition of 30-60°C, mix sodium alginate and water evenly to make a sodium alginate-water solution with a mass-volume concentration of 0.50% (m / v, usually 0.25-0.75%);
[0094] 2. Preparation of zinc chloride-ethanol solution
[0095] Mix zinc chloride with an ethanol solution with a concentration of 70% (usually 60-80%) by volume and vortex to prepare a chlorine concentration of 0.1% (m / v, usually 0.1-0.2%) Zinc chloride-ethanol solution;
[0096] 3. Preparation of paeonifloride-zinc chloride solution
[0097] Add paeonifloride into zinc chloride-ethanol solution, and vortex mix, wherein, the ratio of the mass of paeonifloride to the volume of zinc chloride-ethanol solution is 0.5:100 (usually (0.1- 4): 100, preferably 0.3-0.8:100), that is, 0.5 g of paeonifloride glycoside (usually 0.1-4 g, preferably 0.3-0.8 g) is added to 100 ml o...
Embodiment 2
[0110] Example 2 Preparation of paeonifloride-alginate thermosensitive gel
[0111] 1. Preparation of paeonifloride nanogel-saline solution
[0112] According to the total prescription (that is, the total prescription of paeonifloride thermosensitive gel: normal saline, paeonifloride-zinc alginate nanogel, poloxamer 407, poloxamer 188 (68:12:18:2) ) ratio calculation, adding paeonifloride-zinc alginate nanogel into normal saline, stirring evenly to make paeonifloride nanogel-normal saline solution, wherein paeonifloride-zinc alginate nanogel The ratio of the quality of the glue to the quality of the total prescription is 12% (m / m, usually 10-20%), i.e. the quality of the paeonifloride-zinc alginate nanogel and the total mass of the paeonifloride thermosensitive gel The ratio is 12:100 (usually 10-20:100); the mass ratio of normal saline to the total prescription is 68% (m / m, usually 60-80%);
[0113] 2. Preparation of paeonifloride-poloxamer mixed system
[0114] In an ice ...
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Abstract
The invention discloses thermosensitive gel and a preparation method thereof. Albiflorin with antidepressant activity is carried into nanogel particles to serve as drug-release reservoirs, and throughthe interaction between alginic acid and poloxamer molecular chain segments, the albiflorin-zinc alginate thermosensitive self-assembled gel is constructed. According to the albiflorin controlled-release antidepressant thermosensitive gel prepared through the method, the mode of drug administration through the nose is adopted, and thus the gel can adhere to the surface of the nasal mucosa at thebody temperature to continuously release a drug; the albiflorin directly enters the brain through an olfactory region, is not limited by blood-brain barriers, and can quickly take effect to treat depression; pharmacodynamic experiments prove that an albiflorin thermosensitive self-assembled gel preparation is superior to other drugs or preparation formulations in the aspect of quickly taking effect to resist depression; and the drug delivery and absorption efficiency is improved, the onset time is shortened, a more suitable and more effective novel preparation formulation is provided for treating depression through the albiflorin, and the application range of the thermosensitive gel is enlarged.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a gel with rapid onset of action through nasal administration and a preparation method thereof, in particular to an antidepressant temperature-sensitive gel with nasal administration and a preparation method thereof. Background technique [0002] Depression is a mental illness caused by many factors, mainly depressed. In severe cases, there are thoughts of suicide. The World Health Organization (WHO) estimates that by 2020 depression will become an important disease causing disability and abnormal death. Depression seriously destroys the patient's spirit and body, and brings a heavy burden to the family and society. [0003] The antidepressant drugs that were used clinically earlier were monoamine oxidase inhibitors (MAOI) and tricyclic antidepressants (TCA), followed by selective serotonin reuptake inhibitors (SSRI), the most representative The most popular drugs are fluoxeti...
Claims
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