A kind of thermosensitive gel and preparation method thereof
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A thermosensitive gel and thermosensitive gel technology, applied in the field of medicine, can solve the problems of inability to apply depression treatment well, slow onset of action, large side effects, etc., and achieve suitable large-scale promotion and application, rapid onset of effect, and drug-loading. large amount of effect
Active Publication Date: 2022-04-12
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
[0006] Currently clinically used antidepressant drugs have slow onset of action and large side effects, so they cannot be well applied to the treatment of depression
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Embodiment 1
[0091] Example 1 Preparation of paeonifloride-alginate nanogel
[0092] 1. Preparation of sodium alginate-water solution
[0093] Under the condition of 30-60°C, mix sodium alginate and water evenly to make a sodium alginate-water solution with a mass-volume concentration of 0.50% (m / v, usually 0.25-0.75%);
[0094] 2. Preparation of zinc chloride-ethanol solution
[0095] Mix zinc chloride with an ethanol solution with a concentration of 70% (usually 60-80%) by volume and vortex to prepare a chlorine concentration of 0.1% (m / v, usually 0.1-0.2%) Zinc chloride-ethanol solution;
[0096] 3. Preparation of paeonifloride-zinc chloride solution
[0097] Add paeonifloride into zinc chloride-ethanol solution, and vortex mix, wherein, the ratio of the mass of paeonifloride to the volume of zinc chloride-ethanol solution is 0.5:100 (usually (0.1- 4): 100, preferably 0.3-0.8:100), that is, 0.5 g of paeonifloride glycoside (usually 0.1-4 g, preferably 0.3-0.8 g) is added to 100 ml o...
Embodiment 2
[0110] Example 2 Preparation of paeonifloride-alginate thermosensitive gel
[0111] 1. Preparation of paeonifloride nanogel-saline solution
[0112] According to the total prescription (that is, the total prescription of paeonifloride thermosensitive gel: normal saline, paeonifloride-zinc alginate nanogel, poloxamer 407, poloxamer 188 (68:12:18:2) ) ratio calculation, adding paeonifloride-zinc alginate nanogel into normal saline, stirring evenly to make paeonifloride nanogel-normal saline solution, wherein paeonifloride-zinc alginate nanogel The ratio of the quality of the glue to the quality of the total prescription is 12% (m / m, usually 10-20%), i.e. the quality of the paeonifloride-zinc alginate nanogel and the total mass of the paeonifloride thermosensitive gel The ratio is 12:100 (usually 10-20:100); the mass ratio of normal saline to the total prescription is 68% (m / m, usually 60-80%);
[0113] 2. Preparation of paeonifloride-poloxamer mixed system
[0114] In an ice ...
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Abstract
The invention discloses a temperature-sensitive gel and a preparation method thereof. Paeonifloride glycosides with antidepressant activity are loaded into zinc alginate nanogel particles as a drug release storehouse, and the drug is released through alginic acid and poloxamer molecules. Interaction between chain segments to construct paeonolide-zinc alginate temperature-sensitive self-assembled gel. The controlled-release paeonifloride glycoside antidepressant temperature-sensitive gel prepared by the method of the invention is administered through the nose, so that the gel can adhere to the surface of the nasal mucosa at body temperature and release the medicine continuously. Paeonifloride directly enters the brain through the olfactory area, without being restricted by the blood-brain barrier, and can quickly treat depression. Pharmacodynamic experiments have proved that paeonifloride thermosensitive self-assembled gel preparation is superior to other drugs or dosage forms in rapid onset antidepressant. The delivery and absorption efficiency of the drug is improved and the onset time is shortened, which provides a more suitable and effective new dosage form for paeonifloride in the treatment of depression, and expands its application range.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a gel with rapid onset of action through nasal administration and a preparation method thereof, in particular to an antidepressant temperature-sensitive gel with nasal administration and a preparation method thereof. Background technique [0002] Depression is a mental illness caused by many factors, mainly depressed. In severe cases, there are thoughts of suicide. The World Health Organization (WHO) estimates that by 2020 depression will become an important disease causing disability and abnormal death. Depression seriously destroys the patient's spirit and body, and brings a heavy burden to the family and society. [0003] The antidepressant drugs that were used clinically earlier were monoamine oxidase inhibitors (MAOI) and tricyclic antidepressants (TCA), followed by selective serotonin reuptake inhibitors (SSRI), the most representative The most popular drugs are fluoxeti...
Claims
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