Nanoparticle containing 5-methylpyrimidine-2, 4 (1H, 3H)-diketone derivative and preparation method and application thereof
A technology of derivatives and nanoparticles, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, pharmaceutical formulas, etc.
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[0015] In order to solve the above problems, the present invention provides the following technical solutions.
[0016] In a first aspect, the present invention provides a nanoparticle.
[0017] A kind of nanoparticle, it comprises: as shown in formula I compound and auxiliary material,
[0018]
[0019] Wherein, m is selected from an integer of 0-5; n is selected from an integer of 5-20. In some embodiments, m is 0, 1, 2, 3, 4 or 5, n is 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20.
[0020] In some embodiments, the compound represented by the formula I is a compound represented by NBD002,
[0021]
[0022] The compound of formula I can be synthesized by Michael addition reaction.
[0023] The auxiliary material includes at least one selected from: PEG derivatives, lipids, lipidoids, alcohols or inorganic salts. In some embodiments, the auxiliary material includes at least one selected from the group consisting of PEG derivatives, lipids and lipidoid...
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