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Radix astragali particle and quality control method thereof

A quality control method and technology of Astragalus, which are applied in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems that the quality control of Astragalus granules is not accurate and reliable, and it is impossible to ensure clinical curative effect, etc. and retention, improving clinical effectiveness, changing the effect of decoction time

Inactive Publication Date: 2009-01-14
SICHUAN BAILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In this traditional method, only ninhydrin color reaction and thin-layer chromatography are used to qualitatively identify the astragaloside IV contained therein, without involving any content determination. Obviously, this is not accurate enough for the quality control of Huangqi granules Reliable, and it is impossible to ensure its clinical efficacy

Method used

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  • Radix astragali particle and quality control method thereof
  • Radix astragali particle and quality control method thereof
  • Radix astragali particle and quality control method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Present embodiment is the astragalus granule obtained by the following method:

[0037] Take 1000g of astragalus and add water to decoct twice, decoct for 2 hours for the first time, decoct for 2 hours for the second time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of about 1.30 (70°C), add an appropriate amount of sucrose , made into 1000g of granules, dried, divided into 15g / bag, sterilized, and obtained.

Embodiment 2

[0039] Present embodiment is the astragalus granule obtained by the following method:

[0040] Take 1000g of Astragalus membranaceus, add water and decoct twice, decoct for 2.5 hours for the first time, and decoct for 1.5 hours for the second time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of about 1.20 (80°C), add an appropriate amount of lactose , made into 1000g of granules, dried, divided into 10g / bag, sterilized, and obtained.

Embodiment 3

[0042] Present embodiment is the astragalus granule obtained by the following method:

[0043] Take 1000g of Radix Astragali, add water and decoct twice, decoct for 1.5 hours for the first time, decoct for 2.5 hours for the second time, combine the decoction, filter, and decompress the filtrate (pressure -0.06mpa~-0.07mpa, temperature 55~60℃ ) concentrated to a clear paste with a relative density of about 1.25 (75°C), adding an appropriate amount of xylitol to make 1000 g of granules, drying, subpackaging into 10 g / bag, and sterilizing to obtain.

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Abstract

The invention discloses a raidx astragali particle. The radix astragali particle is prepared by a following method: the medicinal materials of the radix astragali are decocted with water and extracted twice; the medicinal materials of the radix astragali are decocted for 1.5 to 2.5hours every time; decoctions are put together and filtered; filtrate is concentrated into a clear paste with relative density of 1.20 to 1.30 (70 to 80 DEG C); auxiliary materials are added and mixed evenly; then the medicinal materials of the radix astragali and the auxiliary materials are processed by granulation, drying, sub-package and sterilization; and the raidx astragali particle is made. The radix astragali particle is prepared by the new method and the procedures of alcohol precipitation is reduced. That decoction time is changed is beneficial to the dissolution and preservation of effective components. As a result, the effective components of the medicinal materials of the radix astragali, including astragalus polysaccharides and total saponin, and the like, are reserved in the radix astragali particle as much as possible, thus greatly improving the content of the effective components so as to improve the clinical effectiveness of the raidx astragali. Meanwhile, production period is greatly shortened; energy consumption is decreased; and cost is lowered. The invention also provides a quality control method of the raidx astragali particle.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation technology and quality control, in particular to an astragalus granule and a quality control method thereof. Background technique [0002] Astragalus, also known as Astragalus membranaceus or Astragalus, is a leguminous, perennial herb. The main root is long, cylindrical, slightly woody, and the outer mass is khaki or brownish red. It likes drought and has strong adaptability. Distributed in Hebei, Shanxi, Shaanxi, Gansu, Qinghai, Liaoning, Jilin, Heilongjiang, Inner Mongolia and other places. [0003] The root of Astragalus membranaceus is well-known and commonly used in traditional Chinese medicine. Commercial Astragalus membranaceus is cylindrical, slightly twisted, and 20-60 cm long. It is better to have thick and long strips, less wrinkles, firm and soft texture, enough powder, and sweet taste. It mainly contains coumarin, flavonoids, saponins, trace amounts of folic acid and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/16G01N30/36A61P7/10A61P9/12A61P13/12A61P15/00A61P17/02
Inventor 曾大富
Owner SICHUAN BAILI PHARM CO LTD
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