The invention discloses a
lovastatin-containing
enteric coated sustained-release pellet
capsule and a preparation method thereof. The
lovastatin-containing
enteric coated sustained-release pellet
capsule comprises two parts, namely, an
enteric coated sustained-release pellet and a hollow
capsule, wherein the enteric coated sustained-release pellet comprises 55-86% of
medicine-containing pellet core, 2-5% of isolation
coating layer, 2-15% of a sustained-release
coating layer and 10-25% of enteric-coated
coating layer by weight. The prepared
lovastatin enteric coated sustained-release pellet capsule is uniform in granule size and stable in
medicine release; the
medicine is not released in
gastric acid but is slowly and constantly released in intestinal tracts and livers, has the characteristic of targeted medicine release, is small in
irritation to gastrointestinal tracts, and can reduce the toxic and side effects of the medicine and reduce the number of the medicine administrations, so that the compliance of patients is improved; and meanwhile as the enteric coated sustained-release pellet preparation is composed of hundreds of
pellets of uniform granule sizes, the sudden release of the whole preparation is not caused by the breakage of individual
pellets, so that the medicine is
safer than a sustained-release tablet, smaller in
irritation to gastrointestinal tracts and more stable in
blood concentration, and the
clinical effectiveness and security are effectively improved.