Cyclovirobuxine-D sustained-release micro-pill capsules and preparation method thereof
A technology for sustained-release pellets and sustained-release preparations, which is applied to the field of oral chemical drug sustained-release preparations, can solve the problems of low bioavailability, many times of taking, easy mixing and unevenness, and achieves good product uniformity and bioavailability. High strength, good slow release effect
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Embodiment 1
[0022] Embodiment 1: Preparation of Huangyangning Sustained-release Pellet Capsules
[0023] 1. Composition and formula of Huangyangning Sustained-release Pellet Capsules:
[0024] Cyclovitamin D 3.0g
[0025] Blank ball core 1 10.0g
[0026] Acrylic resin RS100 1.34g
[0027] Ethylcellulose 9.15g (dry weight)
[0028] Dibutyl sebacate 2.20g
[0030]
[0031] Make 1000 capsules
[0032] 2. Preparation method:
[0033] 1) Take 1.34g of adhesive acrylic resin RS100, add ethanol until it is completely dissolved, take 110.0g of blank pellet core and put it in a coating pan, and spray the prepared binder solution evenly on the blank pellet core with a spray gun; 3.0g of Huanwei Buxiculus D (powder) was evenly sprayed on the above-mentioned blank ball cores containing binders around the above-mentioned surroundings by spraying liquid and powdering method, sieved, and dried with hot air for 8 hours to prepare ...
Embodiment 2
[0037] Embodiment 2: Preparation of Huangyangning Sustained-release Pellet Capsules
[0038] 1. Composition and formula of Huangyangning Sustained-release Pellet Capsules:
[0039] Cyclovitamin D 1.5g
[0040] Blank ball core 130.0g
[0041] Acrylic resin RS100 1.95g
[0042] Ethyl cellulose 10.0g (dry weight)
[0043] Dibutyl sebacate 1.50g
[0044] Talc powder 0.8g
[0045]
[0046] Make 1000 capsules
[0047] 2. Preparation method: with embodiment 1.
Embodiment 3
[0048] Embodiment 3: Preparation of Huangyangning Sustained-release Pellet Capsules
[0049] 1. Composition and formula of Huangyangning Sustained-release Pellet Capsules:
[0050] Cyclovitamin D 5.0g
[0051] Blank ball core 100.0g
[0052] Acrylic RS100 3.8g
[0053] Ethyl cellulose 6.5g (dry weight)
[0054] Dibutyl sebacate 3.00g
[0055] Talc powder 0.95g
[0056]
[0057] Make 1000 capsules
[0058] 2. Preparation method: with embodiment 1.
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