153 results about "Capsule drugs" patented technology

The present invention discloses amoxicillin capsules and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The amoxicillin capsules comprise, by mass, 100 parts of amoxicillin, 0.1-1 part of sodium lauryl sulfate, 0.1-3 parts of talc powder, and 0.25-2.0 parts of magnesium stearate. According to the present invention, the raw material amoxicillin particle size and the proportion of the auxiliary material are adjusted so as to ensure the high amoxicillin dissolution, avoid the use of sodium carboxymethyl starch, cross-linked povidone and other disintegrating agents, and reduce the amoxicillin capsule volume; and the production preparation steps of the amoxicillin capsule drug are simplified, the production cost is reduced, the polymer impurity content in the amoxicillin capsules is reduced, and the production efficiency is improved.

The invention relates to a machine vision based two section type capsule drug plate quality detection device and method. The device comprises a first conveyor belt, a drug plate detection mechanism, arejected product sorting mechanism, a second conveyor belt, and a controller, wherein the drug plate detection mechanism and the rejected product sorting mechanism are arranged in sequence along theconveying direction, the drug plate detection mechanism comprises a back image collector for collecting the back images of a drug plate, a front image collector for collecting the front images of thedrug plate, a mechanical arm mechanism for fetching the drug plate and turning over the back of the drug plate, and an image processor for identifying rejected products, and the controller is connected to the first conveyor belt, the image processor, the rejected product sorting mechanism, and the second conveyor belt. Compared with the prior art, the provided device and method are suitable for identifying and sorting the defects of two section type capsule drug plates usually used in medicine, can replace artificial visual detection, which has the disadvantages of low efficiency and bad precision, to some degree, and satisfy the large scale and standard production requirements of enterprises.

The invention relates to a nano-micro drug delivery system and a preparation method of a slightly soluble drug of 10-hydroxyl camptothecin (HCPT). The invention makes use of alginate to dissolve HCPT under alkalic condition; then acidic calcium chloride miniemulsion is added to the prepared uniform HCPT-containing emulsion to have crosslinking and curing reactions; at the time when the emulation droplets cure, the HCPT constellation is partially transformed, so that the HCPT crystallize; and then, an acidic chitosan solution or an acidic chitosan derivative is used for secondly curing so as to let the HCPT to crystallize further more. The product prepared through the method is a composite alginate chitosan microsphere or a micro-capsule drug delivery system loaded with HCPT with uniform size and stable dispersion. The nano microspheres of the system have uniform grain size and stable dispersion and the drugs in the nano microspheres exist in the form of closed-loop medicinal nanocrystalline. The invention can realize the increase of solubility of indissolvable drugs and the improvement of bioavailability and effectively improves the encapsulation rate of the indissolvable drugs.

This invention provides capsules containing an emetic, which capsules can encapsulate a drug, wherein the amount of emetic and the amount of drug is such that the number of capsules needed to be ingested to cause emesis is fewer than the number of capsules needed to be ingested to cause overdose of the drug, so that if a person takes an overdose of the emetic encapsulated drug, he or she will vomit before the drug is absorbed by the body.

The invention discloses a Qianliexin capsule quality evaluation method based on multi-index active ingredient measurement. The Qianliexin capsule quality evaluation method is characterized by comprising the following steps: on the basis of an efficient liquid chromatography-electrospray time of flight mass spectrum technology, measuring eight active ingredients in the Qianliexin capsule, and constructing a Qianliexin capsule HPLC (High Performance Liquid Chromatography) fingerprint chromatogram, wherein the eight active ingredients are respectively gallic acid, chlorogenic acid, caffeic acid, vaccarin, isoquercitrin, salvianolic acid B, salvianolic acid A and cryptotanshinone. The efficient liquid chromatography-electrospray time of flight mass spectrum technology is simultaneously adopted to measure the eight active ingredients in the Qianliexin capsule and construct the Qianliexin capsule HPLC fingerprint chromatogram, and meanwhile, the Qianliexin capsule quality evaluation method is used for evaluating the quality of a Qianliexin capsule medicine, and the eight active ingredients and the chromatogram realize mutual corroboration so as to more comprehensively reflect the quality of the Qianliexin capsule medicine to be favorable for researching and guaranteeing the quality of Qianliexin capsule medicine raw materials and preparations.

The invention discloses a capsule filling and cleaning integration device. The capsule filling and cleaning integration device comprises a filling mechanism, a cleaning mechanism, a collecting mechanism, a control mechanism and a base, wherein the filling mechanism comprises a capsule drug injector, a capsule upper-half shell installation device and a first conveying belt, and a plurality of capsule lower-half shell installation grooves are evenly distributed in the first conveying belt; the cleaning mechanism comprises a receiving port, a vibration conveying plate, a second conveying belt, dust removers and ion draught fans; and the collecting mechanism comprise a vibration collecting plate, drying lamps and ultraviolet sterilization lamps. The capsule filling and cleaning integration device accurately fills capsules, through cooperation of the filling mechanism and the cleaning mechanism and cooperation of the dust removers and the ion draught fans, not only are large particle dust on the surfaces of the capsules removed, but also tiny dust adsorbed on the surfaces of the capsules can be effectively removed, and the hygiene and cleanliness of the capsules are guaranteed; and theeffects of drying and sterilizing the dedusted capsules falling onto the vibration collecting plate are realized under the irradiation of the drying lamps and the ultraviolet sterilization lamps.

The invention relates to a method for treating a capsule drug for surface anesthesia of anesthesiology department. The method comprises the following steps: 1) taking out a capsule treatment device and disinfecting, wherein the capsule treatment device comprises a clamping shell and an adsorbing head; the clamping shell comprises a rectangular base plate, a lateral plate, a vertical insert strip, a horizontal insert slot and a front baffle; the adsorbing head comprises an accommodating slot, an air vent, a piston chamber, a driving chamber, a threaded rod, a piston, a driving nut, a driving worm and a rear through hole; 2) placing the capsule; 3) adsorbing the capsule; 4) collecting drugs. The method has the advantages of high reliability, high operation precision and convenience in operation; the structure of the capsule can be kept complete; the method is especially suitable for the splitting of independent capsule.

It has a complex shaped hollow body with front mouthpiece (2) covered by dust cap. Drug strip (1) is held in channel (7) with a drug hole (6). Handle (4) with a sharp piercing rod (5) moves on a pivot (10) at the body back. The pierced powder falls through drug hole (6) into drug chamber (23) with a bottom sliding drug release plate (11) having a knob (8), a spring (14) enclosed in sleeves (15,17) and having a drug hole (12). The hollow body has the back air hole (3) with a dust filter (22), then narrows to a jet hole (19) & continues as hollow mouthpiece. A baffle mesh (16) breaks falling powder into a spray. To use, drug strip (1) is pierced by handle (4), inhaler kept in mouth, and knob (8) pressed and inhaled. Plate (11) slides drug hole (12), drug falls on baffle (16), air jet breaks and forms drug spray for more lung deposit. For drugs in capsule, the inhaler is modified with middle placed capsule (26) with a back piercing rod (25).

The invention relates to a method for collecting capsule drugs, the method comprises the following steps that (1), a drug treatment device are taken out, sterilized and disinfected, specifically the drug treatment device comprises a handheld outer shell, a double-row gear, a negative pressure control switch, a negative pressure generating device and a displacement control switch; the handheld outer shell comprises a first jack, a second jack, a displacement sliding hole, a horizontal cutting and a vertical cutting; the double-row gear comprises a driving gear disk and a driven gear disk; the negative pressure control switch comprises a horizontal rack, a limiting bolt, an elastic component and a pressing plate; the negative pressure generating device comprises a vertical rack, a piston, a piston barrel, a fixed sucking head and a movable sucking head; the displacement control switch comprises a push rod, an upper pressing plate, compression springs and a connecting rod; (2), capsules are stored; (3), the capsules are absorbed; (4), the capsules are broken up; and (5), the drugs are collected. The method for collecting the capsule drugs is easy to operate and efficient and quick, does not destroy the capsule structure and is suitable for the situation that a single capsule is broken up.

The invention discloses an equal division device for capsule drugs and an equal uniform method thereof. The equal division device for the capsule drugs comprises a controller, a screening dividing andcounting mechanism, a push mechanism, a circulating feed mechanism, and a conveying mechanism which are arranged at a machine box; the controller is arranged the bottom of the machine box, a push endof the push mechanism is perpendicular to the side surface of the screening dividing and counting mechanism, the conveying mechanism is arranged at a residual feed scavenging end of the screening score mechanism, the conveying direction of the conveying mechanism and the push direction of the push mechanism are separately perpendicular to the residual feed scavenging direction of the screening score mechanism, and the conveying direction of the conveying mechanism is opposite to the push direction of the push mechanism; and the positions of the push mechanism, the screening score mechanism, the conveying mechanism, and the circulating feed mechanism in the machine box form a U-shaped track. According to the equal division device for the capsule drugs and the equal division method thereof,the capsule drugs can be uniformly divided according to the number of the capsule drugs, the working efficiency is high, and convenient promotion is achieved.

The invention discloses a quality control method of a Shuganjieyu capsule, which can measure a Shuganjieyu capsule fingerprint atlas through a high efficiency liquid chromatography method and can effectively monitor the medicine quality. The method comprises the steps of firstly establishing a Shuganjieyu capsule contrast fingerprint spectrogram, measuring a product fingerprint atlas to be detected of the Shuganjieyu capsule, finally comparing the product fingerprint atlas to be detected of the Shuganjieyu capsule with the comparison fingerprint atlas of the Shugan jieyu capsule, recognizing the quantity of the same absorption peak, and determining whether the product quality is qualified. The method provided by the invention has the advantages that information of main chemical components in the fingerprint atlas is compared, so that the quality control of a medicine is preformed from the substance group entirety of the medicine and a macroscopical angle, and the medicine quality of the Shuganjieyu capsule is reasonably reflected.

The invention relates to a precision regulating pediatric capsule drug treatment device for splitting capsules. The device comprises a hand-held housing, a fixing clamp plug for clamping a front halfportion of a capsule, a movable suction tube for clamping a rear end of the capsule, a central pull rod for pulling the movable suction tube to move backward and a rest pressure spring for pushing themovable suction tube forward to rest; the fixing clamp plug comprises a soft plug body and a hard plug handle; the movable suction tube comprises a suction tube housing, a fixed sealing ring, a suction tube nut, a spacing inner ring and a first side rod; the central pull rod comprises a pull rod body, a movable sealing ring, an adjusting core rod, a pull rod nut and a rest pressure spring. According to the precision regulating pediatric capsule drug treatment device, the structure is reasonable and the operation is simple; it is also possible to adjust the degree of sealing between the movable sealing ring and the suction tube housing; it is also possible to adjust the maximum suction force of the movable suction tube to the rear end of the capsule.

The invention relates to a venlafaxine hydrochloride slow-release capsule and a preparation method thereof. A drug-containing core of the slow-release capsule comprises venlafaxine hydrochloride, microcrystalline cellulose, gas phase silica, Tween-80, and hydroxypropyl methylcellulose; a slow-release coating comprises polyacrylic resin, talcum powder, polyethylene glycol and lauryl sodium sulfate. The invention realizes a pure water system for the capsule production by the addition of gas phase silica to change material flowing, and the selection of slow-release coating. The venlafaxine hydrochloride slow-release capsule prepared by the system is stable in drug release, has effective continuous release time of 24 hours, and is taken only once a day. The method is simple in process, mild in condition, free of any organic solvent, low in equipment requirements, and suitable for industrial production.

The invention relates to an azithromycin capsule which comprises azithromycin capsule comprises azithromycin, a filling agent, an adhesive and a glidant, and further relates to a preparation method of the azithromycin capsule. In the technical scheme, raw materials are made into a micropill capsule, and medicines are uniformly dispersed, so that the problem that the main medicine has low probability of absorbing water is solved, the product quality is improved, and the medicine stability is guaranteed. The capsule has the advantages of high dissolution speed and high bioavailability, and the preparation method provided by the invention is simple to operate, is under mild conditions and is suitable for large-scale industrial production.

The invention discloses a capsule stability quick-detection device, and relates to the technical field of capsule medicines. The invention aims to provide the capsule stability quick-detection devicewhich can detect the qualification of size and dimension of a capsule and can detect the stability between two sections of the capsule. The capsule stability quick-detection device comprises a supporting seat, a motor, a fan-shaped gear, a rotary shaft, a pinion and a rotary disc; the motor is installed on one side face of the upper part of the supporting seat; the fan-shaped gear is installed onan output shaft of the motor via a rotating shaft; the rotary shaft is installed at one end of the upper part of the supporting seat via a bearing and penetrates the supporting seat; the pinion is installed at one end of the rotary shaft; and the rotary disc is installed at the other end of the rotary shaft. According to the device, the capsule can be conveyed via a circular blocking plate and size of the capsule can be detected; and stability of the capsule can be detected via a clamping detection mechanism.

The invention discloses a Febuxostat capsule drug combination and a preparation method thereof. The Febuxostat capsule drug combination is characterized in that: ingredients for preparing 1000 capsules are as follows: 80-120g of Febuxostat, 120-180g of lactose (MeggleC80), 20-30g of microcrystalline cellulose (JRS12), 10-15g of croscarmellose sodium, and 1-1.5g of magnesium stearate. The invention also relates to the preparation method of the Febuxostat capsule drug combination, comprising the steps of: respectively drying the raw materials and the auxiliary materials at 80 DEG C for 3 hours, evenly mixing in equal proportion, and filling in capsules. The Febuxostat capsule prepared by the prescription and the preparation method provided by the invention has the advantages of good fluidity, good dissolution, small quality difference, high bioavailability, and good curative effect.

A natural carotin soft capsule for improving immunity and disease resistance, delaying senility and preventing and treating cancer is prepared from Halophila extract, refined corn oil, VE and span-80through grinding the mixture of Halophila extract and 80% of the refined corn oil in a colloidal mill, mixing with others and die pressing.

The invention discloses a method for identifying components of capsule medicine for treating hemorrhoids. Thin layer chromatography is used to respectively identify Chinese fevervine, Gerbera piloselloides and bushy knotweed root of capsule particles, and then high-efficiency liquid chromatography is adopted to quantify archen and polydatin in bushy knotweed root. The method not only can accurately identify the components such as Chinese fevervine, Gerbera piloselloides, bushy knotweed root and the like in the capsule medicine, but also can quantify the content of archen and polydatin in bushy knotweed root, so the quality control of the medicine is facilitated and the safety and the reliability of the medicine are improved.

The invention relates to a boxing device, in particular to a capsule medicine plate boxing device for medical production. The technical problem to be solved is to provide the capsule medicine plate boxing device which improves the working efficiency and reduces unnecessary losses and is used for medical production. According to the technical scheme, the capsule medicine plate boxing device for medical production comprises a bottom plate, a motor, an incomplete bevel gear, a supporting table, a baffle and a first supporting block. The motor is arranged at the top of the bottom plate. The incomplete bevel gear is arranged at the upper part of an output shaft of the motor. The supporting table is arranged at the top of the bottom plate. The baffle is arranged at the top of the supporting table. The first supporting block is arranged in the middle of the top in the supporting table. By arranging a discharging mechanism, capsule medicine plates can be intermittently discharged onto a conveying belt. By arranging a fixing mechanism, people do not need to manually rotate a fried dough twist rod. By arranging a collecting mechanism, people can conveniently collect medicine boxes, filled with the capsule medicine plates, in a collecting box.

A capsule drug for treatment of the intestinal ascariasis relates to a Chinese herb formulation for the therapy of the intestinal ascariasis. The medicine comprises the following raw material, which comprises 80g to 100g JunZi meat and 80g to 100g rhubarb as well as 70g to 80g brown sugar. The present invention has the advantages of convenient material selection, convenient preparation, low cost and quick effect.

Disclosed is a novel synthesis and cross-linking method which can completely degrading intraosseous fixed polymer. The invention adopts 1, 2-propylene glycol (or ethylene glycol ), dineopentyl alcohol neopentyl glycol, maleic anhydride, phthalic anhydride, glycin (or caprolactam) and cyclohexanol as raw material to synthesize an adjustable, innocuous, low-cost unsaturated polyesteramide, by a method of melt phase polycondensation and molecular chain end capping. By adding an amount of crosslinking agent (vinyl acetate or vinyl pyrrolidone) and initiating heat treatment after the accelerant crosslinking at room temperature, the completely degradable intraosseous fixed material with high strength can be produced. The unsaturated polyesteramide can also be developed into completely-degradable disposable tablewares, packing materials, flowerpots, medical supplies, drug-coating or basis materials such as delayed (controlled) release materials for capsules and drugs, glass fiber reinforced plastics etc.

The invention discloses a drug for treating acquired immune deficiency syndrome. The drug is prepared from dozens of Chinese medicinal herbs; and calculus bovis, musk, daemonorops draco, tianlong (Chinese character), venenum bufonis, centipede, borneol, leech, turtle shell, turtleback, ginseng, scorpio, manis pentadactyla and the like are combined, crushed and grinded, so as to prepare a capsule drug. The traditional Chinese medicines are traditional medicines, accord with the mandatory standard, have hundreds of years or thousands of years of history in China, and are prepared into the drug according to the compatibility principles of 'monarch, minister, assistant and guide'. The drug disclosed by the invention does not have incompatibilities such as eighteen incompatibilities, nineteen counteraction and the like and is not chemically processed; and the pure traditional Chinese medicines are taken as the materials in the entire formula. Therefore, the targets of being nutrient but not greasy, attacking but not damage, nursing in efficacy, overall treatment and a plurality of ways are achieved by the entire formula; and multi-target regulation is an ideal prescription.

The invention relates to a capsule medicine breaking device for the anesthesiology department. The capsule medicine breaking device for the anesthesiology department comprises a fixed supporting box,an L-shaped fixing rod, a base, a collecting cylinder, a first springs and a rectangular supporting pipe, wherein the fixed supporting box is fixed onto the base through the L-shaped fixing rod; the collecting cylinder is arranged on the upper end face of the base; the rectangular supporting pipe is arranged below the fixed supporting box; and a plurality of first springs are arranged. According to the capsule medicine breaking device for the anesthesiology department, in the using process, complete dismantling of capsules can be achieved, subsequent continuous use is facilitated, and internalanesthetic agents can be automatically taken out through slight vibration in the dismantling process, so that the working efficiency is improved, meanwhile, the labor cost can be saved, the time-saving and labor-saving effects are achieved, and in the actual use process, a higher application value is achieved.

The invention relates to a method for controlling the quality of a corydalis tuber paregoric capsule and belongs to the technical field of quality control of drug preparations. The method for controlling the quality of the corydalis tuber paregoric capsule is based on character identification of the prior capsule drug material, adopts a thin layer chromatography method to carry out content mensuration on tetrahydropalmatine, precisely extracts solutions of a test sample and a reference substance, drops the solutions on the same silica gel G plate and uses n-hexane-acetic ether-ammonia (6:4:0.2, volume ratio) as a developing agent; the drops are developed, colored, taken out and scanned by the chromatography method; the wavelength lambda s is equal to 345 nm; and lambda R is equal to 307 nm; and the integral quantity of absorbance of the test sample and the absorbance of the reference substance are measured and calculated to obtain the content of the tetrahydropalmatine in a content of the corydalis tuber paregoric capsule. The method for the quality control has simple operation, an accurate result, precision, stability and good repeatability so as to accurately and effectively control the quality of the corydalis tuber paregoric capsule, so the method is favorable for ensuring the exertion of clinical treatment effect.

The invention discloses a dutasteride soft capsule medicine composition. Contents of the dutasteride soft capsule medicine composition comprise dutasteride, an oil phase and an antioxidant. A capsulecase comprises gelatin, glycerin, a surfactant, an opacifier and a pigment, wherein the surfactant is one or two kinds of materials of lauryl sodium sulfate or sodium stearate. The dutasteride soft capsule medicine composition using the recipe provided by the invention has the advantage that the migration of the dutasteride in the contents towards the capsule case can be effectively prevented.