71 results about "Capsule drugs" patented technology

The invention relates to the technical field of medicine quality detection, in particular to a capsule medicine multi-mode defect detection system and a multi-dimensional detection method, and the detection system comprises a detection container filled with an intelligent response type medicinal silicone oil composition, a transmission system, a detection mechanism, a control system and a rejection mechanism. Through density adjustment, temperature-sensitive-fluorescence response and multi-mode detection technologies, accurate detection of defects such as capsule liquid leakage, cracks and poor sealing can be realized. The detection method adjusts the silicone oil density according to the capsule type, and collects, fuses and analyzes buoyancy signals and optical image data to judge defects. According to the invention, the detection precision is high, and 0.02 [mu] L-level leakage and 0.1 mm-level cracks can be detected; the compatibility is strong, and the method is suitable for 95% of commercially available capsules; the cost is low, the equipment and maintenance cost is greatly reduced, and silicone oil can be recycled; the medicine production specifications are met.

The invention discloses a capsule medicament for endoscopic treatment of ulcerative colitis and a preparation method thereof, and belongs to the technical field of biological medicine, the capsule medicament is composed of a capsule matrix and a drug matrix; by adopting a dual control mechanism of an enteric layer coating and a pH response layer coating, accurate release of a medicine at a colon diseased region is ensured, medicine waste of the stomach and the small intestine is reduced, the medicine concentration at a focus is improved, mesalazine or budesonide is combined with the composite composition for treatment, inflammatory response is rapidly inhibited, acute symptoms are controlled, and the curative effect is good. A multi-mechanism synergistic treatment mode is adopted, the anti-inflammatory and repairing effects are enhanced, the clinical remission rate and the mucous membrane healing rate are remarkably improved, the pH response layer is dissolved in a colon alkaline environment, and the MMP-9 peptide cross-linking agent is subjected to enzymolysis at an inflammation part, so that the medicine is continuously released at a focus, the administration frequency is reduced, the compliance of a patient is improved, and the curative effect is good. In addition, the spherical gel particles in the medicament can prevent the medicament from being disintegrated too early in the intestinal tract, and the long-acting effect can be maintained.

The invention discloses capsule medicine production equipment based on an intelligent temperature control and constant humidity environment and a process thereof. The capsule medicine production equipment comprises an operation table, a medicine capsule shell placing mechanism, an intelligent rotating disc, a control unit, a powder stirring mechanism, a rotating disc with holes and a long column. A control unit is fixedly connected to one side of the top of the operation table, and a powder stirring mechanism is arranged on one side of the outer portion of the control unit. The interior of the powder stirring mechanism is fixedly connected with a long column; the long column comprises a stirring column, a movable rod, a mounting seat and a fixing ring, the top of the stirring column is fixedly connected with an intelligent temperature control ring, the exterior of the stirring column is rotatably connected with the movable rod, and the end, away from the stirring column, of the exterior of the movable rod is rotatably connected to the exterior of the long column; the control unit is matched with the temperature display instrument, the temperature sensor and the intelligent temperature control ring, so that the temperature of the production environment can be monitored and adjusted in real time, deliquescence, caking or component deterioration of capsule powder due to temperature and humidity fluctuation is avoided, the drug activity and quality stability are ensured, and the adaptability is high.

The invention relates to the technical field of medicine capsule production, and particularly discloses a preparation process for improving the filling quality of a Xinan capsule, which comprises the following six steps: weighing 4-5kg of hawthorn leaf extract powder and 0.5 kg of corn starch, then taking 95% ethanol, preparing a soft material, granulating, drying, crushing, adding auxiliary materials during total mixing, and filling. The auxiliary materials for improving the flowability of the medicine powder are added into the crushed medicine powder, and the auxiliary materials are mixed to cover the surface of the powder to form a hydrophobic layer and directly block water contact, so that the flowability of the medicine powder is realized, the difference between the medicine loading amount and the standard amount can be very small during filling, and the safety of the prepared capsule medicine is ensured.

The invention discloses preparation of an anti-chronic pharyngitis microcapsule medicine and application of the anti-chronic pharyngitis microcapsule medicine in tipping paper for cigarettes, the medicine is MF-GA / IL (at) MPN, and the medicine is composed of an ionic liquid (IL) as an internal carrier and a microcapsule carrier with a metal phenol network (MPN) as a shell; wherein the metal phenol network is formed by aluminum ions and mangiferin through a coordination reaction, and the ionic liquid is CAGE ILs formed by vanillin and choline. The combination of mangiferin and glycyrrhizic acid is used as a strategy for treating chronic pharyngitis, it is found that the effective loaded MF-GA / IL-coated MPN microcapsule preparation is obtained by packaging the two drugs including mangiferin and glycyrrhizic acid with the ionic liquid as the core and the metal phenol network as the shell, the tissue permeability of the drugs is improved, a certain slow release effect is achieved, and the effect of treating chronic pharyngitis is achieved. The bioavailability of mangiferin and glycyrrhizic acid is improved, and the anti-inflammatory activity effect is better achieved.

The utility model discloses an anti-blocking filling machine for capsule medicine preparation and belongs to the technical field of medicine production. A medicine inlet is formed in the upper end of the shell, a stirring mechanism is arranged in the shell and fixedly connected with an anti-blocking mechanism, the anti-blocking mechanism is arranged in a conveying pipe, the conveying pipe is fixedly communicated with the upper end of the shell, a discharging port is formed in the lower end of the conveying pipe, an electronic valve is arranged on the discharging port, and the outer wall of the lower end of the conveying pipe is fixedly connected with a connecting frame. The connecting frame is fixedly connected with the fixing plate, the fixing plate is provided with a filling mechanism, and the filling mechanism corresponds to the discharging port. By means of the unique design and working principle, the capsule medicine preparation device has the remarkable advantages of being efficient in stirring, excellent in anti-blocking performance, accurate in filling, easy and convenient to operate, wide in application and the like, and efficient, reliable and automatic capsule medicine preparation equipment is provided for the pharmaceutical industry.

The utility model relates to capsule medicine powder filling mechanism, its stock bin stirring filling device is installed on stock bin support swing arm, and the transmission connection between filling transmission mandrel and stirring transmission hollow shaft is by linkage part, and hollow support stand column is arranged on the mesa panel of frame, and hollow pivot connection configuration is in hollow support stand column, and power mandrel connection configuration is in hollow pivot, and the upper end of power mandrel is with the upper end transmission connection of filling transmission mandrel, and the lower end of power mandrel is with mandrel drive motor transmission connection, and stock bin support swing arm is connected in hollow pivot, and stock bin support swing arm is located the top of hollow support stand column, and the lower end of hollow pivot is with pivot drive part transmission connection. Hollow support stand column and other structures on the column are supported by the mesa panel of frame, and the load of stock bin support swing arm is relatively reduced, and operation is relatively more stable, and the support structure and power transmission structure help to promote the operation stability and service life of optimization filling mechanism.

The utility model discloses a soft capsule pill forming machine, and belongs to the technical field of capsule forming machines. A soft capsule pill forming machine comprises a rotationally-arranged rolling cage, a feeding port is formed in one end of the rolling cage, the rolling cage comprises a drying cage close to one end of the feeding port and a cooling cage far away from one end of the feeding port, a spiral channel is arranged between the drying cage and the cooling cage, a vortex tube is arranged below the drying cage, and the spiral channel is communicated with the spiral channel. A hot air outlet of the vortex tube faces the drying cage; the soft capsule pill drying device has the advantages that the heating mechanism is simple in structure, and dried soft capsule pills can be conveniently and rapidly cooled.

The utility model relates to a medicine powder filling mechanism for capsule medicine processing, which comprises an adjusting mechanism, the left side of the adjusting mechanism is fixedly provided with a support, the top of the adjusting mechanism is provided with a feeding mechanism, the inside of the feeding mechanism is provided with a maintenance mechanism, and the maintenance mechanism comprises a fixing column. And the fixing column is fixedly installed in the feeding mechanism, a heating rod is fixedly installed outside the fixing column, and a scraping plate is fixedly installed outside the fixing column and located below the heating rod. According to the medicine powder filling mechanism for capsule medicine processing, through the arrangement of the maintenance mechanism, the adjusting mechanism and the feeding mechanism, the feeding mechanism and the adjusting mechanism can be conveniently separated and cleaned, meanwhile, the temperature can be changed according to different types of medicine powder, the overall use range of the mechanism is widened, and the flexibility of the mechanism is improved; and through the arrangement of the adjusting mechanism and the feeding mechanism, quantitative feeding of the medicine powder is achieved, the medicine powder filling efficiency and precision are improved, and the capsule medicine quality is guaranteed.

The invention discloses a medicine smashing device, and belongs to the technical field of medicine smashing. Comprising a crushing storage cavity used for crushing stored particles, a crushing device used for crushing particle medicines, a driving device used for driving the crushing device to operate, a capsule medicine storage cavity used for storing capsule medicines for taking, and a stirring and mixing device used for carrying out mixing operation on the interior of the capsule storage cavity. The transmission device is used for driving the stirring and mixing device in a transmission manner; the capsule separating device is used for separating capsules; according to the device, granular medicine can be crushed, so that a patient with dysphagia or a patient with digestive absorption capacity can take the medicine conveniently, the medicine can be better received and absorbed to be effectively treated conveniently, meanwhile, capsule medicine can be separated and then mixed with warm water to be taken, and the medicine taking efficiency is improved. And the capsule can be taken without being separated and mixed with warm water, so that the medicine taking of patients with dysphagia or digestive absorption capability is effectively improved.

The utility model provides an automatic capsule aluminum plastic packaging device, which relates to the technical field of capsules and comprises an integral structure and supporting structures, and the supporting structures are positioned at the front and rear positions of the two sides of the bottom of the integral structure; the whole structure comprises a bottom plate, one side of the top of the bottom plate is fixedly connected with a box body, a feeding pipe is arranged at the front position and the rear position of the top of the box body in a penetrating mode, an electromagnetic valve is fixedly installed on the outer surface of the feeding pipe, and a first conveying belt is fixedly installed at the position, close to the center, of one side of the inner surface of the box body. After a user pours capsule medicine into a feeding pipe, the user can put an aluminum-plastic packaging box on a second conveying belt, and through cooperation of a second conveying pipeline and an infrared sensor, the position of the aluminum-plastic packaging box can correspond to the position of a conveying piece; through mutual cooperation of the electromagnetic valve, the control panel, the first conveying belt and the conveying piece, quantitative feeding operation can be automatically carried out.

The present invention belongs to the technical field of medical devices, and particularly relates to a dry powder inhalation device with a rotating multi-capsule channel that is sequentially opened for inhalation, which is mainly used for administering in the form of a dry powder inhalant, and includes: a mouthpiece; a housing, a chamber is formed inside the housing; a plurality of capsule compartments are formed in the chamber and can be communicated with the mouthpiece; a diversion part is movably arranged between the mouthpiece and the plurality of capsule compartments to communicate the mouthpiece with one capsule compartment; a driving part is connected to the housing and the diversion assembly, and the driving part can rotate relative to the housing to drive the diversion assembly to move between the mouthpiece and the plurality of capsule compartments, so that different capsule compartments are communicated with the mouthpiece, solving the problem that: in the existing multi-capsule powder inhaler, when the user inhales the drug through the mouthpiece, the mouthpiece is communicated with each capsule compartment, resulting in the user's suction being dispersed into each capsule compartment, making it difficult for the user to inhale the drug, and thus reducing the inhalation efficiency.

1. Name of the product of this design: Packaging box series (capsule medicine). 2. Purpose of this design product: a packaging box for medicines. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: Design 1 3D drawing. 5. Designate Design 1 as the base design.

The application belongs to the technical field of quality detection of traditional Chinese medicine preparation, and provides a method for establishing volatile / liposoluble component fingerprint spectrum of Xinnaoning capsules. The method comprises establishing volatile component fingerprint spectrum of Xinnaoning capsules and establishing liposoluble component fingerprint spectrum of Xinnaoning capsules, and is to take Xinnaoning capsule drug preparation as a detection object, and to establish a fingerprint spectrum method for the drug preparation by using gas chromatography and mass spectrometry. The method for establishing volatile / liposoluble component fingerprint spectrum of Xinnaoning capsules has the advantages of high stability, high precision and good repeatability. Moreover, the method can evaluate the similarity of liposoluble compounds of Xinnaoning capsules, and provide technical support for realizing more comprehensive and effective control of product quality.

The invention discloses a method for analyzing a pharmacodynamic material basis and metabolites of Longqing capsules. According to the method, an UPLC-Q-Exactive-Orbitrap MS technology is adopted, under the same chromatographic condition and mass spectrum condition, the pharmacodynamic material basis and metabolites of the Longqing capsules are measured and analyzed, 128 compounds are analyzed from the Longqing capsules, 144 exogenous compounds including 61 prototype components and 83 metabolites are analyzed from plasma, urine and excrement of rats in total, and the pharmacodynamic material basis and the metabolites of the Longqing capsules are analyzed to form the Longqing capsules with the pharmacodynamic material basis and the metabolites of the Longqing capsules with the pharmacodynamic material basis and the metabolites of the Longqing capsules with the pharmacodynamic material basis and the metabolites of the Longqing capsules. The main metabolic pathways comprise oxidation, reduction, hydrolysis, methylation, sulfation, glucuronization, composite reactions of various reaction types and the like. The invention provides a scientific basis for quality control and clinical reasonable medication of Longqing capsule medicines.

The utility model provides a multifunctional soft capsule packaging machine which comprises a fixing bottom plate, a containing groove is formed in the upper end of the fixing bottom plate, a conveying belt is fixedly connected to the lower inner wall of the containing groove, a mounting frame is fixedly connected to the upper end of the fixing bottom plate, and an adjusting assembly is arranged at the upper end of the mounting frame. The adjusting assembly comprises a second air cylinder, a butt joint frame, a supporting frame, a sliding rod, a limiting disc, a spring, a pressing head, a rotating shaft and a sealing roller, and the second air cylinder is fixedly connected to the left side end of the mounting frame. The soft capsule medicine packaging device is reasonable in structure and good in practicability, when different kinds of soft capsule medicine are packaged, the height of the limiting strip can be adjusted, so that the sealing roller can seal different soft capsule medicine plates and tinfoil, and the application range of the device is widened.

1. Name of the Design Product: Medicine Packaging Box (Shenruling Capsules). 2. Use of the Design Product: For packaging Shenruling Capsules. 3. Design Key Points of the Design Product: Lies in the combination of shape, pattern and color. 4. Picture or Photograph Most Indicating the Design Key Points: Front View. 5. The claimed design includes color.

This utility model relates to the field of pharmaceutical packaging technology, specifically to a capsule pharmaceutical packaging machine. This device, through precise mechanical coordination, ensures that each capsule enters its designated position independently and vertically during the packaging process. Under the continuous action of the vibrating block, the capsules are effectively dispersed and fall one by one into the first through-hole, achieving automatic and neat arrangement. This effectively avoids problems such as capsule tipping or sticking that may occur during manual operation. Subsequently, the capsules accurately fall into the second through-hole of the feeding plate. Each hole is strictly limited to accommodating only a single capsule. The feeding plate is driven by a lead screw to perform precise and controllable step-by-step movement, ensuring that only when the second through-hole moves to the predetermined position will the capsule be released due to the loss of base support. This combination of physical isolation and precise displacement fundamentally guarantees the absolute accuracy and consistency of the packaging quantity each time, greatly reducing packaging errors and achieving a high degree of automation and continuous operation.

The present invention relates to the technical field of pharmaceutical quality inspection, specifically a multi-modal defect detection system and multi-dimensional detection method for capsule drugs. The detection system includes a detection container filled with an intelligent-responsive pharmaceutical-grade silicone oil composition, a transmission system, a detection mechanism, a control system, and a rejection mechanism. Through density adjustment, temperature-sensitive-fluorescent response, and multi-modal detection technologies, precise detection of defects such as capsule liquid leakage, cracks, and poor sealing can be achieved. The detection method adjusts the silicone oil density according to the capsule type, and collects and fuses and analyzes buoyancy signals and optical image data to judge defects. The invention has high detection accuracy, can detect liquid leakage at the level of 0.02 μL and cracks at the level of 0.1 mm; has strong compatibility, is applicable to more than 95% of commercially available capsules; has low cost, with significantly reduced equipment and maintenance costs, and the silicone oil can be recycled; and complies with pharmaceutical production specifications.

1. Name of the designed product: medicine package box (Rhododendron simsi oil capsule). 2. Use of the designed product: the designed product is used for the package of capsule medicine. 3. Design points of the designed product: the combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The utility model discloses a radioactive capsule medicine subpackaging device which comprises a shell, and a first material storage barrel, a second material storage barrel and a third material storage barrel which are used for storing different kinds of radioactive capsules are sequentially installed at the top end of the shell from left to right. A first discharging mechanism, a second discharging mechanism and a third discharging mechanism which are used for discharging materials from the first storage barrel, the second storage barrel and the third storage barrel are respectively arranged at the bottom ends of the first storage barrel, the second storage barrel and the third storage barrel; the first discharging mechanism, the second discharging mechanism and the third discharging mechanism are each provided with an annular discharging plate, and the inner side walls of the annular discharging plates are connected with the octagonal prism through connecting rods. According to the utility model, different types of radioactive capsule medicines can be singly discharged and sub-packaged, and different types of radioactive capsule medicines can be discharged and sub-packaged according to different proportions, so that the radioactive capsule medicine discharging and sub-packaging device is convenient for workers to use.

The utility model relates to a medicine bottle technical field, concretely is a kind of sealed moisture-proof medicine bottle, including bottle body, the upper end of bottle body is threadedly connected with bottle cap, the bottom inner wall of bottle body is fixedly connected with sealing box, sealing box is filled with drying agent, the inner wall of sealing box is fixedly connected with permeable membrane, the outer circumferential surface of sealing box is fixedly connected with extension ring, extension ring is fixedly connected with bottle body, the inner circumferential surface of extension ring is equipped with several air holes, the inner wall of sealing box is fixedly assembled with baffle, baffle is located above permeable membrane, baffle is polypropylene material quality.The utility model, by setting sealing box, extension ring and air hole etc. component, by extension ring and air hole cooperation, can in the case where sealing box is covered by capsule medicine, make the air in bottle body pass through extension ring and enter sealing box, then be dried by drying agent, to ensure the drying effect of drying agent, improve the moisture-proof performance of medicine bottle.

The utility model relates to the technical field of capsule detection equipment, in particular to soft capsule appearance flaw detection equipment. The utility model provides soft capsule appearance flaw detection equipment which comprises a flaw detector body and a device frame, and a supporting table is fixed to the top of the device frame. By arranging the discharging mechanism, the collecting box, the material blocking frame, the first discharging opening and the second discharging opening, during detection, a medicine plate for packaging a plurality of capsules is placed in a placing area in the discharging mechanism, and two driving motors drive a moving plate to move to the position below the defect detector body to stop; then the air cylinder and the flaw detector body are started to detect flaws of a plurality of capsules, after detection is completed, the driving motor continues to be started to enable the moving plate to move to the first discharging opening and the second discharging opening, and therefore capsule medicine plates fall into the collecting box to achieve the rapid discharging function, manual discharging is avoided, manpower is saved, and the working efficiency is improved. And the detection efficiency is improved.

The utility model belongs to the technical field of pharmacy, and particularly relates to a capsule medicine racking machine which comprises a machine box and further comprises a conveying device fixedly installed on the top of the machine box. The number of the electric push rods is two, and the bottom ends of the two electric push rods are fixedly installed on the top of the machine box; the bottom of the hopper and output shafts of the two electric push rods are fixedly installed, and the bottom of the hopper fixedly communicates with a discharging pipe; the fixed circular plate is fixedly mounted on the inner wall of the hopper, and an opening is formed in the fixed circular plate; the rotary circular plate is placed at the top of the fixed circular plate; by means of the simple structure, when capsule medicine is bottled, the number of the medicine can be accurately controlled, deviation of the bottling number is avoided, unqualified medicine packaging finished products are reduced, secondary packaging is carried out, time and labor are saved, the production cost is reduced, and the packaging efficiency is improved.

Capsule pharmaceutical compositions of MRTX1133 (4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1Hpyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol) in suspension; methods for preparing these compositions, and methods of their use for the treatment of 5 various diseases and disorders.

The utility model provides a high-speed rotary tablet press for isosorbide mononitrate sustained-release capsule medicaments, belongs to the technical field of pharmaceutical production, and aims to solve the problem that a rotary processing part is easy to hurt people when the rotary processing part is operated by the people at present. Comprising a tabletting main body, a tabletting rotating plate, an operation panel, an emergency stop switch, a protective rotating shaft, a shutdown pressing block, a protective plate switching mechanism and a maintenance shutdown mechanism, the tablet pressing part is arranged in the tablet pressing main body; the operation panel is fixedly connected to the right end face of the pressing piece body. The emergency stop switch is fixedly connected to the front side of the operation panel; the protective rotating shaft is rotationally connected to the interior of the pressing sheet main body; the shutdown pressing block is connected to the interior of the pressing sheet main body in a sliding manner; the protective plate switching mechanism is arranged in the tablet pressing main body; and the maintenance shutdown mechanism is arranged on the right side in the tabletting main body. By means of the protection plate opening and closing mechanism, personnel can maintain the tablet pressing part conveniently, and by means of the maintenance stopping mechanism, the safety of the personnel for maintaining the tablet press is guaranteed.

A soft capsule medicament premixing device comprises a barrel and a barrel cover on the upper side of the barrel, a premixing mechanism is arranged on the lower side of the barrel cover and comprises a main rod horizontally and rotatably arranged and a motor capable of driving the main rod to rotate, sliding seats are slidably arranged at the two ends of the main rod in the length direction of the main rod, stirring units are arranged on the lower sides of the sliding seats, and the premixing mechanism further comprises an adjusting unit. The motor is in transmission connection with the two sliding seats, the distance between the two sliding seats can be adjusted, the motor can work to drive the main rod to rotate, stirring and mixing work of the medicament is completed through the stirring units on the lower sides of the two ends of the main rod, the stirring effect is guaranteed, and in the stirring process, even if the medicament flows in the stirring direction due to stirring work, the stirring effect is good. Meanwhile, the two groups of stirring units can move along the direction perpendicular to the stirring axis through the action of the adjusting unit, finally, a stirring effect is generated on the flowing medicament in the barrel body, and the stirring effect is ensured by changing the stirring positions of the stirring units.

The invention discloses a method for detecting chemical components in Kujin collateral dredging capsules based on a UPLC-Q-Orbitrap HRMS (High Resolution Mass Spectrometry) technology. The method comprises the steps of preparation of a test solution, detection and analysis of the chemical components, identification of the chemical components and the like. According to the method, pretreatment of the sample solution is simple, detection is accurate and sensitive, consumed time is short, the chemical components in the Kujin collateral dredging capsules can be effectively separated and identified within 25 min, high-throughput analysis and identification of the chemical components in the Kujin collateral dredging capsules are achieved, the chemical components in the Kujin collateral dredging capsules are rapidly and comprehensively analyzed, and the method is suitable for large-scale popularization and application. The basis is provided for further researching the pharmacodynamic material basis and the comprehensive quality control of the Kujin collateral dredging capsule.

The utility model relates to the technical field of capsule medicine disassembling, in particular to a capsule medicine disassembling device which comprises a supporting frame, the supporting frame is of an L-shaped structure, a collecting device is fixedly connected to the upper end of the front side of the supporting frame, a sliding groove is formed in the rear portion of the upper end of the supporting frame, and a disassembling mechanism is movably connected into the sliding groove. According to the capsule medicine disassembling device, the disassembling mechanism is arranged, a capsule is placed in the arc-shaped grooves in the two sliding clamping pieces, the capsule is pressed so that the capsule can be clamped and limited through a plurality of anti-skid protruding strips in the arc-shaped grooves, then the rotating wheel is rotated, the rotating wheel drives the two-way screw to rotate, and the capsule medicine is disassembled through the two-way screw. Due to the fact that the two-way screw is in threaded connection with the two sliding clamping pieces, and the two sliding clamping pieces slide in the sliding groove, when the two-way screw rotates, the two sliding clamping pieces are made to be far away from each other under the action of the sliding groove, and therefore the two sliding clamping pieces are made to disassemble the capsule.