The invention relates to the papermaking field and aims to provide a making process of leather-like paper with high wet strength. The process comprise the following steps: firstly, selecting 30-80 percent by mass of long fiber paper pulp and 20-70 percent by mass of softwood pulp to prepare into mixed paper pulp; then, adding 1-1.5 percent of wet-strength agent relative to the fiber quantity to the paper pulp, wherein the wet-strength agent is any one of PPE (Poly-Phenylene Ether)) and melamine or urea-formaldehyde resin; adding 10-30 percent of latex relative to the fiber quantity to the paper pulp, wherein the latex is any one of silicon oxide, carboxylic styrene-butadiene latex, styrene-acrylic emulsion, water-based polyurethane emulsion and acrylic emulsion; pulping the paper pulp, papermaking by using a round mesh, long mesh or inclined mesh machine, drying and coating; and finally, drying, coiling and forming. The leather-like paper with high wet strength has the advantages of high strength, water absorption, soft paper, leather-like quality and capability of printing characters and patterns, thereby being suitable for high-grade paper capable of printing jean marks, hanging marks, leather marks, name cards, and the like.