Tamsulosin hydrochloride sustained-release pellets and preparation method thereof
A technology of tamsulosin hydrochloride and pellets, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, drug combinations, etc., can solve the problems of unstable coating efficiency with drug content and no release situation.
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Embodiment 1
[0027] Weigh 170 g of microcrystalline cellulose and 10 g of croscarmellose sodium, mix them uniformly, add 180 g of water (containing 269 mg of medicine) to make a soft material, and use a Mini250 extrusion spheronizing fluidized coating machine to prepare medicine-containing pills.
[0028] The drug-containing pills were dried at 50°C for 1 hour, took out and weighed 100g, put them into a Mini250 extruding spheroid fluidized coating machine to preheat for 10min, 60% Su Lisi (ie 15% aqueous ethylcellulose dispersion) coated with 105 g, taken out, and dried at 50° C. for 40 min. Then place the Mini250 type extrusion tumbling fluidized coating machine, Kolicoat MAE 30DP Formula coating liquid (containing 14.5% of polymer, 2.2% of talc, 1.3% of polyethylene glycol 60001.3%) coated 12g, took out, and dried at 50°C for 2 hours to obtain tamsulosin hydrochloride sustained-release pellet preparation.
Embodiment 2
[0030] Weigh 180g of microcrystalline cellulose, 20g of croscarmellose sodium, mix well, add water 210g (containing 371mg of medicine) to make a soft material, and a Mini250 type extrusion spheronizing fluidized coating machine prepares medicine-containing pills.
[0031] The drug-containing pills were dried at 50°C for 1 hour, took out and weighed 100g, put them into a Mini250 extruding spheroid fluidized coating machine to preheat for 10min, 60% Su Lisi (ie 15% ethylcellulose aqueous dispersion) coated with 108g, taken out, and dried at 50°C for 40min. Then place the Mini250 type extrusion tumbling fluidized coating machine, Kolicoat MAE 30DP Formula coating liquid (containing 14.5% of polymer, 2.2% of talc, 1.3% of polyethylene glycol 60001.3%) was coated with 15g, taken out, and dried at 50°C for 2 hours to obtain tamsulosin hydrochloride sustained-release pellet preparation.
Embodiment 3
[0033] Weigh 190 g of microcrystalline cellulose and 30 g of croscarmellose sodium, mix them uniformly, add 210 g of water (containing 371 mg of medicine) to make a soft material, and use a Mini250 extrusion spheronizing fluidized coating machine to prepare medicine-containing pills.
[0034] The drug-containing pills were dried at 50°C for 1 hour, took out and weighed 100g, put them into a Mini250 extruding spheroid fluidized coating machine to preheat for 10min, 60% Su Lisi (ie 15% aqueous ethylcellulose dispersion) coated 110 g, taken out and dried at 50° C. for 40 min.
[0035] Take it out and place it in a Mini250 extrusion spheroid fluidized coating machine, Kolicoat MAE 30DP Formula coating liquid (containing 14.5% of polymer, 2.2% of talc, 1.3% of polyethylene glycol 60001.3%) coated 18g, took out and dried at 50°C for 2 hours to obtain tamsulosin hydrochloride sustained-release pellet preparation.
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