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Venlafaxine hydrochloride pellet capsule and preparation method thereof

A technology of venlafaxine hydrochloride and sustained-release pellets, applied in capsule preparations, venlafaxine hydrochloride sustained-release pellets capsules and their preparation fields, can solve the problems of venlafaxine hydrochloride being released too quickly and the like

Inactive Publication Date: 2015-05-27
TIANJIN YIYAO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing method adopts aqueous dispersion to carry out coating, because the high water solubility of venlafaxine hydrochloride causes venlafaxine hydrochloride to migrate when coating, under the situation that coating film thickness is not enough, venlafaxine hydrochloride Sine may act as a pore-reaching agent, causing too rapid release of venlafaxine hydrochloride

Method used

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  • Venlafaxine hydrochloride pellet capsule and preparation method thereof
  • Venlafaxine hydrochloride pellet capsule and preparation method thereof
  • Venlafaxine hydrochloride pellet capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A venlafaxine hydrochloride sustained-release pellet capsule, comprising a capsule shell and drug-containing pellets placed in the capsule shell, said drug-containing pellets comprising a drug-containing pellet core and a sustained-release capsule wrapped outside the drug-containing pellet core. layer, where:

[0035] Prescription with pill core:

[0036]

[0037] Sustained release layer prescription:

[0038]

[0039] The preparation method is as follows:

[0040] Mix water, cellulose, sucrose and venlafaxine hydrochloride evenly, and extrude the soft material into an extruder (screen diameter: 0.7mm, extrusion speed: 40rpm), and put the extruded material into a spheronizer ( The rotating speed is 300-2200rpm, and the spheronization time is 2 minutes). The spheronized extruded material is dried in a forced air drying oven at 40°C-60°C for 2-4 hours, sieved, and 16-35 mesh pellet cores are taken.

[0041] Coating solution preparation method: add talc and sodium...

Embodiment 2

[0044] A venlafaxine hydrochloride sustained-release pellet capsule, comprising a capsule shell and drug-containing pellets placed in the capsule shell, said drug-containing pellets comprising a drug-containing pellet core and a sustained-release capsule wrapped outside the drug-containing pellet core. layer, where:

[0045] Prescription with pill core:

[0046]

[0047] Sustained release layer prescription:

[0048]

[0049]

[0050] The preparation method is as follows:

[0051] Mix water, cellulose, lactose, sucrose and venlafaxine hydrochloride evenly. The soft material is extruded in an extruder (screen diameter: 0.7mm, extrusion speed: 40rpm), and the extruded material is spheronized in a spheronizer (rotating speed: 300-2200rpm, spheronization time: 2 minutes). Dry the material in a blast drying oven at 40°C-60°C for 2-4 hours, sieve, and take 16-35 mesh pellet cores.

[0052] Coating solution preparation method: Add talc and hydroxypropyl methylcellulose t...

Embodiment 3

[0055] A venlafaxine hydrochloride sustained-release pellet capsule, comprising a capsule shell and drug-containing pellets placed in the capsule shell, said drug-containing pellets comprising a drug-containing pellet core and a sustained-release capsule wrapped outside the drug-containing pellet core. layer, where:

[0056] Prescription with pill core:

[0057]

[0058] Sustained release layer prescription:

[0059]

[0060] The preparation method is as follows:

[0061] Mix water, cellulose, starch, sucrose and venlafaxine hydrochloride evenly. The soft material is extruded in an extruder (screen diameter: 0.7mm, extrusion speed: 40rpm), and the extruded material is spheronized in a spheronizer (rotating speed: 300-2200rpm, spheronization time: 2 minutes). Dry the material in a blast drying oven at 40°C-60°C for 2-4 hours, sieve, and take 16-35 mesh pellet cores.

[0062] Coating solution preparation method: add talc and polyethylene glycol to water and stir evenly...

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Abstract

The invention relates to a venlafaxine hydrochloride slow release capsule and a preparation method thereof. The capsule comprises a capsule shell and a medicated pellet placed in the capsule shell, and the medicated pellet comprises a medicated pellet core and a slow release layer wrapped outside the medicated pellet core. The venlafaxine hydrochloride slow release capsule is an oral administration slow release pellet capsule preparation with venlafaxine hydrochloride as an active medicine component, can be administrated once a day to realize 24h slow release and maintain the therapeutic plasma concentration, and accords requirements of stability, industrial scale production and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and relates to capsule preparations, in particular to a venlafaxine hydrochloride sustained-release pellet capsule and a preparation method thereof. Background technique [0002] Venlafaxine hydrochloride is a new type of antidepressant, and it is the first clinically applied drug that has both serotonin and norepinephrine reuptake inhibitory effects. Its immediate-release dosage form has a higher blood concentration due to the rapid release of the drug, causing a considerable number of patients to experience nausea, vomiting and other adverse reactions. The venlafaxine hydrochloride sustained-release preparation, through the slow release of the drug, obtains a stable blood drug concentration, reduces the incidence of adverse reactions, reduces the number of times of taking the drug, and increases the patient's compliance. Venlafaxine Hydrochloride Sustained-release Capsules were developed by Wy...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/137A61P25/24
Inventor 权超杨晓津
Owner TIANJIN YIYAO SCI & TECH
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