Glipizide film-controlled slow-release pellet capsule

A technology of glipizide film and sustained-release pellets, which is applied in the field of pharmaceutical preparations and can solve the problems of film aging and release decline

Active Publication Date: 2013-07-24
内蒙古天衡医院管理有限公司
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problem of release decline caused by membrane aging of glipizide membrane-controlled sustained-release pellets prepared by water dispersion coating, the present invention provides a membrane-controlled membrane-controlled pellet that can maintain stable release performance throu...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glipizide film-controlled slow-release pellet capsule
  • Glipizide film-controlled slow-release pellet capsule
  • Glipizide film-controlled slow-release pellet capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The glipizide sustained-release pellet capsule of the common pellet core of embodiment 1

[0029] 1. Prescription

[0030] 1. Pill core prescription (1000 capsules)

[0031]

[0032]

[0033] 2. Prescription of sustained-release film coating solution

[0034]

[0035] 3. No. 0 stomach-dissolving gelatin capsule shells, 1,000 capsules.

[0036] Second, the preparation process:

[0037] 1. Ball core preparation process:

[0038] (1) Glipizide is passed through an 80-mesh sieve;

[0039] (2) Take glipizide, microcrystalline cellulose PH101, lactose, sodium lauryl sulfate of prescription quantity, put in the wet granulator and mix uniformly;

[0040] (3) make soft material with 2% carboxymethylcellulose sodium 10% ethanol solution;

[0041] (4) Extrude on the extruder, the screen aperture is 1.0mm, and the extrusion speed is 20-30rpm;

[0042] (5) spheronization, the spheronization speed is 900~1000rpm, drying in the fluidized bed;

[0043] (6) Sieve, and tak...

Embodiment 2

[0071] Example 2 Glipizide Sustained-release Pellet Capsules Containing 5% Sodium Carboxymethyl Starch

[0072] 1. Prescription

[0073] 1. Pill core prescription (1000 capsules)

[0074]

[0075] 2. Prescription of sustained-release film coating solution: same as in Example 1

[0076] 3. No. 0 stomach-soluble gelatin capsule shell 1000 capsules

[0077] Second, the preparation process:

[0078] 1. Ball core preparation process:

[0079] (1) Glipizide is passed through a 60-mesh sieve;

[0080] (2) Glipizide, microcrystalline cellulose PH101, lactose, carboxymethyl starch sodium, sodium lauryl sulfate are taken by weighing prescription quantity, put in the wet granulator and mix uniformly;

[0081] (3) make soft material with 2% carboxymethylcellulose sodium 10% ethanol solution;

[0082] (4) Extrude on the extruder, the screen aperture is 1.0mm, and the extrusion speed is 20-30rpm;

[0083] (5) spheronization, the spheronization speed is 900~1000rpm, drying in the f...

Embodiment 3

[0100] Example 3 Glipizide Sustained-release Pellet Capsules Containing 10% Sodium Carboxymethyl Starch

[0101] 1. Prescription

[0102] 1. Pill core prescription (1000 capsules)

[0103]

[0104] 2. Prescription of sustained-release film coating solution: same as in Example 1.

[0105] 3. No. 0 stomach-dissolving gelatin capsule shells, 1,000 capsules.

[0106] Second, the preparation process:

[0107] 1. Ball core preparation process: with embodiment 2.

[0108] 2. The preparation process of the slow-release film coating solution: the same as in Example 1.

[0109] 3. Coating (sustained release film):

[0110] The ball core is placed in a fluidized bed for coating, and the weight gain of the coating film is controlled, and the weight gain of the coating is 22.1% and 26.8%.

[0111] 4, heat treatment: with embodiment 1

[0112] 5. Capsule filling: same as in Example 1.

[0113] 3. Release, content determination and results

[0114] Assay method: with embodiment 1, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a glipizide film-controlled slow-release pellet capsule. A slow-release film of the glipizide film-controlled slow-release pellet utilizes Eurdragit RL 30D as a film-formation material. A pellet core of the glipizide film-controlled slow-release pellet contains sodium carboxymethyl starch having high expansibility, and also contains pharmaceutically-acceptable common excipients for the slow-release pellet, wherein preferably, the excipients comprise microcrystalline cellulose, lactose and sodium dodecyl sulfate, and the pellet core comprises 5 to 20wt% of sodium carboxymethyl starch. The slow-release film comprises Eurdragit RL 30D, triethyl citrate as a plasticizer and talcum powder as an antiplastering aid, wherein preferably, a ratio of Eurdragit RL 30D to triethyl citrate to talcum powder is 30: 3: 4 and a film weight increasing ratio is in a range of 17 to 36%. The glipizide film-controlled slow-release pellet comprises the pellet core containing sodium carboxymethyl starch having high water expansibility and thus after absorbing water, the glipizide film-controlled slow-release pellet obviously expands so that the slow-release film is stretched; the thickness of the slow-release film is reduced; the water-permeable micropore size is increased; and permeability is improved and the permeability reduction caused by film aging is counteracted. Therefore, in middle and later stages, the glipizide film-controlled slow-release pellet release rate is basically constant; in the last stage, residues are less; and stable release performances can be kept in the period of validity.

Description

technical field [0001] The invention relates to a glipizide membrane-controlled sustained-release pellet capsule, in particular to a glipizide membrane-controlled sustained-release pellet capsule whose pellet core contains sodium carboxymethyl starch, and belongs to the field of pharmaceutical preparations. Background technique [0002] Glipizide is an oral hypoglycemic drug of the sulfonylurea class, which can promote the secretion of insulin by pancreatic β cells and enhance the effect of insulin on target tissues; it can also stimulate pancreatic α cells to inhibit the secretion of glucagon, as well as inhibit glycogen Protolysis, promoting muscle utilization and consumption of glucose, for the treatment of type 2 diabetes. [0003] Glipizide is almost insoluble in water, and the earliest common preparation on the market needs to be taken 3 times a day, the blood concentration fluctuates greatly, the peak concentration is too high, and the adverse reactions are serious. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/52A61K31/64A61K47/32A61K47/36A61K47/38A61P3/10
Inventor 姜庆伟狄媛吕玉珠唐亚坤刘俊轶
Owner 内蒙古天衡医院管理有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap