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Perceptual training methods for inducing plasticity in the auditory cortex for non-therapeutic purposes

A training method and plastic technology, applied in the field of life science/medicine, to achieve the effect of improving dysfunction, improving auditory cortex dysfunction, and improving frequency selectivity

Active Publication Date: 2022-04-05
EAST CHINA NORMAL UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the current frequency perception training paradigm can only strengthen the task-related frequency representative area limitedly, which is manifested in the expansion of the area of ​​the task-related representative area and the strengthening of the function of the frequency representative area, while the frequency of neurons outside the task-related representative area Selectivity disappears or does not change

Method used

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  • Perceptual training methods for inducing plasticity in the auditory cortex for non-therapeutic purposes
  • Perceptual training methods for inducing plasticity in the auditory cortex for non-therapeutic purposes
  • Perceptual training methods for inducing plasticity in the auditory cortex for non-therapeutic purposes

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Experimental program
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Embodiment 1

[0048] The training process is generally divided into four stages. In the first stage, the rats gradually learn to trigger the photoelectric sensor (Nose-poke) during free activities in the experimental device, so as to obtain food rewards (Bio-Serve, 45mg). When the rat successfully triggers the sensor 100 times, it can enter the next stage. stage training. In the second stage, the horn gives a pure tone with a frequency of 6.5kHz (target frequency), and the rat needs to learn to touch the sensor after hearing the sound to obtain food rewards. Within 3 seconds after the target sound is given, if the rat triggers the sensor, it will be defined as Hit (Go), and a food reward will be obtained at the same time; otherwise, it will be defined as Miss (No-go), and it will be prompted to turn off the light for 12 seconds, waiting for recovery Lighting into the next training session. Every 100 training sessions is recorded as one round, and 10 rounds of training are performed every ...

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Abstract

The invention belongs to the field of life science / medical technology, and discloses a non-therapeutic perceptual training method for inducing the plasticity of the auditory cortex, which includes a training device, which is located in a sound-proof shielding box, including a controller, a sound generator, Loudspeaker, food feeder, infrared nose detector and lighting lamp. The invention also discloses the application of the training device in induction of auditory cortical plasticity and perception training. The invention has the characteristics of non-invasiveness and broad spectrum, improves the frequency selectivity of auditory cortex neurons, and has wide application prospects.

Description

technical field [0001] The invention belongs to the field of life science / medical technology, and relates to a technical solution for improving the plasticity of the brain sensory system and maintaining brain health, in particular to a sensory training device, method and application based on the plasticity of the auditory cortex without pain training stimulation. Background technique [0002] After birth in mammals, the brain undergoes a rapid maturation process. During the critical period of development, the structure and function of the brain are easily affected by factors such as environment and experience, and have great plasticity. However, for post-critical period (Post-critical period) adult animals, the induction, expression and regulation mechanism of brain plasticity are significantly different from those of juvenile animals in the critical period. For example, in the critical period, dynamic sound exposure can induce the auditory cortex of the brain to undergo st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K15/02
CPCA01K15/029
Inventor 程远安鹏颖张贵敏周晓明
Owner EAST CHINA NORMAL UNIV
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