Application of extracellular vesicles derived from mesenchymal stem cells in cerebral ischemia-reperfusion injury

A technology with purpose and right and wrong, applied in the application field of extracellular vesicles in cerebral ischemia-reperfusion injury, can solve problems such as incompletely clear mechanisms, and achieve the effect of reducing neurological deficits, tissue damage, and apoptosis
CN111297898BActive Publication Date: 2022-01-25SHANDONG UNIV QILU HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG UNIV QILU HOSPITAL
Publication Date
2022-01-25

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Abstract

The invention provides the application of extracellular vesicles derived from mesenchymal stem cells in cerebral ischemia-reperfusion injury. The present invention discovers and confirms that extracellular vesicles (MSCs-EVs) derived from mesenchymal stem cells can treat brain dysfunction and neuroprotection through neurogenesis and angiogenesis after stroke. The results of the study showed that MSCs-EVs could significantly alleviate the neurological deficit at 24h and 48h after MCAO in rats, reduce the volume of cerebral infarction and brain water content, improve the pathological damage of the cortex of the brain tissue, and attenuate the apoptosis of cortical neurons and significantly up-regulate p‑AMPK, while p‑JAK2, p‑STAT3 and p‑NF‑κB were downregulated. The present invention provides essential support for the use of MSCs‑EVs as a potential therapeutic strategy for MCAO treatment.
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Description

technical field

[0001] The invention belongs to the technical field of crude drugs and medicine, and in particular relates to the application of extracellular vesicles derived from mesenchymal stem cells in cerebral ischemia-reperfusion injury. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] Cerebrovascular disease is the third leading cause of death in the world and one of the leading causes of death among Chinese residents. Its morbidity and mortality are increasing year by year, bringing heavy burden to society and economy. Ischemic stroke accounts for 75-80% of all strokes, and the incidence rate is significantly higher than that of hemorrhagic stroke. The pathologi...

Claims

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