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miR-25-3p, application and application method thereof

An application method and neuron technology, applied in the field of biomedicine, can solve the problems of difficult recovery of functions and limited speed of nerve regeneration.

Pending Publication Date: 2022-02-25
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problem in the prior art that the regeneration speed is limited after nerve damage, which ultimately leads to difficult recovery of function

Method used

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  • miR-25-3p, application and application method thereof
  • miR-25-3p, application and application method thereof
  • miR-25-3p, application and application method thereof

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Embodiment Construction

[0030] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to specific embodiments.

[0031] Many specific details are set forth in the following description to facilitate a full understanding of the present invention, however, the present invention may also be implemented in other ways than those described herein, and therefore, the present invention is not limited to the specific embodiments disclosed in the following description. limit.

[0032] The present application provides a miR-25-3p, as a molecular intervention target, overexpressing miR-25-3p to promote the growth of DGR neurons and cortical neuron axons.

[0033] The present application also provides an application of miR-25-3p, which participates in peripheral nerve injury repair by regulating DGR neuron axon growth, and participates in central nerve injury repair by regulating cortical ...

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Abstract

The invention provides miR-25-3p as well as application and an application method thereof, and relates to the technical field of biomedicine, the miR-25-3p is used as a molecular intervention target, and overexpresses the miR-25-3p so as to promote growth of DGR neuron and cortical neuron axons. The miR-25-3p participates in peripheral nerve injury repair by adjusting the growth of DGR neuron axons. The miR-25-3p participates in central nervous system injury repair by adjusting cortical neuron axon growth. According to the invention, firstly, a small RNA, that is, miR-25-3p is found through screening, and is found can play an important role in nerve injury repair. The miR-25-3p mimic is transfected in the in-vitro DRG neuron, so that the growth of the DRG neuron subjected to primary culture and cortical neuron axons can be obviously promoted. The miR-25-3p can participate in peripheral nerve injury repair by adjusting DRG neuron axon growth, and can also participate in central nerve injury repair by adjusting cortical neuron axon growth. The important effect of miRNA in the nerve injury repair process can be better understood, and a new target spot is provided for treatment after nerve injury.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a miR-25-3p, an application and an application method thereof. Background technique [0002] The repair of nerve injury is a common clinical problem, which causes a great burden to the society and family. Peripheral nerves can regenerate spontaneously after injury, but due to the limited regeneration speed, it will eventually lead to difficult recovery of function. At the same time, spinal cord injury is one of the devastating diseases that lead to impaired neurological function and reduced quality of life, with high morbidity and mortality, economical and a heavy burden on society. Therefore, fully exploring the cellular and molecular mechanisms of nerve injury regeneration will help to promote nerve function repair and provide a theoretical basis for clinical treatment. [0003] MicroRNA (miRNA) is an endogenous non-coding small RNA with a length of about 21-23 nucleoti...

Claims

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Application Information

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IPC IPC(8): C12N15/113C12N15/87C12N5/10A61K31/7088A61P25/02A61P25/28
CPCC12N15/113C12N15/87C12N5/0619A61K31/7088A61P25/02A61P25/28C12N2320/30C12N2510/00
Inventor 周松林丁斐从猛张琦沈宓刘畅
Owner NANTONG UNIVERSITY
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