The invention relates to a conductive
parallel fiber membrane which is capable of promoting rapid repair of
peripheral nervous tissues and is connected to an
extracellular matrix, wherein the thin film (the
fiber membrane) can serve as a biofunctional nerve
scaffold. The conductive
parallel fiber membrane which is connected to the
extracellular matrix and is of a core-shell structure is prepared by virtue of a three-
step method, namely preparing parallel fibers through electrostatic
spinning, covering conductive
polypyrrole through electrochemical oxidation, and conducting
human skin fibroblast culture and splitting cells by virtue of a triton x-100 /
ammonia water
mixed solution. According to the invention, the composite
fiber membrane, by virtue of the parallel structure, can guide the growth of nerve fibers in a directional mode, by virtue of the
extracellular matrix, adhesion of the
nerve cells and
axon thereof is improved, and by virtue of the
conductive polymer (the conductive
polypyrrole), the growth of the
nerve axon is promoted through electric stimulation; and with a synergistic effect among the three means, the regeneration and repair of nerves are promoted. A preparation device adopted by the invention is simple and easy, simple to operate, wide in material source and low in cost; and the prepared nerve
scaffold is good in
biocompatibility and functionality, and the nerve
scaffold is expected to be applied to clinical field in the future.