3 results about "Axon growth" patented technology

The application discloses application of an ACSS1 gene in preparation of a drug for promoting growth of neuron axons in vitro, and belongs to the technical field of biological medicines. The application knows that expression of the ACSS1 protein presents a progressive downward trend with time passing after injury through construction of a spinal cord injury model and collection of spinal cord tissues, and then the adeno-associated virus is used to overexpress the ACSS1 in neuron primary cells, and the result shows that the length of neuron axons is significantly increased after overexpression of the ACSS1. Therefore, a substance for promoting expression of the ACSS1 gene can be used as a reagent for preparing a drug for promoting growth of neuron axons in vitro.

The application discloses a nerve regeneration guide conduit for promoting nerve cell differentiation and a preparation method and application thereof. The nerve regeneration guide conduit can realize stable and long-acting release of bioactive factors, effectively reduce the risk of tissue adhesion, efficiently induce nerve cell differentiation, promote axon growth and function recovery, and provides a novel and effective solution for nerve regeneration and repair. In addition, the nerve regeneration guide conduit has excellent conductivity, biocompatibility, mechanical adaptability and the like, and therefore has a wide application prospect in the field of nerve regeneration and repair.

This invention discloses a neurofilament light chain protein derivative, biomaterial, and its applications. The neurofilament light chain protein derivative is a protein based on the neurofilament light chain protein or its homologous protein with the sequence shown in SEQ ID NO: 1, wherein one or more amino acid residues in the Coil 2B region have pharmaceutically acceptable modifications or mutations. This invention designs and constructs a neurofilament light chain protein K316Q mutant by acetylation-mimicking mutation of the neurofilament light chain protein, which exhibits significant effects in promoting nerve growth and regeneration. This mutant can enhance the stability and function of neurofilament networks, promote the expansion of axonal growth cones, and directly target the intrinsic growth capacity of neurons, demonstrating excellent clinical translational potential.