9 results about "Axon growth" patented technology

The invention discloses an application of a CDKN1A interaction zinc finger protein 1 in neuronal axon regulation and control. The invention proposes and verifies that the CDKN1A interaction zinc finger protein 1 can effectively regulate and control the growth behavior of neuron axons for the first time, the growth of the neuron axons and the regeneration of damaged axons can be promoted by inhibiting the expression of the CDKN1A interaction zinc finger protein 1, and a new direction is provided for research and development of drugs for treating diseases caused by neurodegenerative diseases and nerve injuries.

The invention discloses application of a deubiquitinating enzyme inhibitor and an OTUD7A-HINT1-mTOR axis in regeneration of a central nervous system, and belongs to the technical field of biology. The technical problem to be solved by the invention is how to promote the regeneration of the central nervous system. The invention finds that the deubiquitinating enzyme inhibitor PR-619 can promote the growth of axons in neuron cultures and retina explants, protect the survival of RGCs and enhance the regeneration of axons after ONC. The PR-619 can also promote CNS regeneration by down-regulating expression of HINT1, HINT is one of main targets of the PR-619 and plays a role through an mTOR signal channel, and OTUD7A serves as an upstream regulation factor of the HINT1. The PR-619 can be used for treating the CNS injury, the OTUD7A-HINT1-mTOR axis can be used as a CNS injury treatment target, and the PR-619 and the OTUD7A-HINT1-mTOR axis can be combined for treating the CNS injury.

The application discloses a nerve regeneration guide conduit for promoting nerve cell differentiation and a preparation method and application thereof. The nerve regeneration guide conduit can realize stable and long-acting release of bioactive factors, effectively reduce the risk of tissue adhesion, efficiently induce nerve cell differentiation, promote axon growth and function recovery, and provides a novel and effective solution for nerve regeneration and repair. In addition, the nerve regeneration guide conduit has excellent conductivity, biocompatibility, mechanical adaptability and the like, and therefore has a wide application prospect in the field of nerve regeneration and repair.

The invention relates to a neural stem cell-parathymosin composite cell preparation and application thereof in treatment of nerve injury diseases. According to the invention, it is found for the first time that neural stem cells overexpressing parathymosin (PTMS) can effectively promote neuron neogenesis and axon growth in in-vitro and in-vivo experiments; animal experiment results show that the traditional Chinese medicine composition can also be used as a treatment means for promoting nerve regeneration to resist dyskinesia related to nerve injury diseases.

The invention relates to the technical field of microbial medicines, and particularly discloses application of intestinal golden thread bacteria in preparation of a medicine for preventing or treating peripheral nerve injury. A mouse model proves that the intestinal golden thread bacteria can regulate the injury microenvironment in the peripheral nerve injury repair process, guide nerve axons to extend in the expected direction and reduce uncontrolled axon growth and wrong dominance, so that the structural accuracy of nerve regeneration is improved.

The application discloses application of an ACSS2 gene in preparation of a medicine for treating or repairing nerve injury, and belongs to the technical field of biological medicines. The application finds, through transcriptome sequencing results of spinal cord injury and sciatic nerve pinch injury, that the expression of ACSS2 presents a gradually decreasing trend after spinal cord injury and sciatic nerve pinch injury, and then the application adopts an adeno-associated virus to overexpress ACSS2 in neuron primary cells, and the result shows that the length of neuron axons is significantly increased after overexpression of ACSS2. Therefore, a substance for promoting the expression of the ACSS2 gene can realize treatment or repair of nerve injury by promoting the growth of neuron axons.

A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.

This invention discloses a neurofilament light chain protein derivative, biomaterial, and its applications. The neurofilament light chain protein derivative is a protein based on the neurofilament light chain protein or its homologous protein with the sequence shown in SEQ ID NO: 1, wherein one or more amino acid residues in the Coil 2B region have pharmaceutically acceptable modifications or mutations. This invention designs and constructs a neurofilament light chain protein K316Q mutant by acetylation-mimicking mutation of the neurofilament light chain protein, which exhibits significant effects in promoting nerve growth and regeneration. This mutant can enhance the stability and function of neurofilament networks, promote the expansion of axonal growth cones, and directly target the intrinsic growth capacity of neurons, demonstrating excellent clinical translational potential.