7 results about "Self-assembling peptide" patented technology

[Problem] The present invention provides a hemostatic composition and a hemostatic method using the hemostatic composition, and specifically provides a composition for hemostasis that can be uniformly applied to a bleeding site and exert a high hemostatic effect. [Solution] A composition to be applied as a spray to a subject is provided, wherein the composition is characterized in that the spray is for hemostasis, and the composition comprises a self-assembling peptide that gels due to self-assembly when the composition is applied to a bleeding site of the subject, and the self-assembling peptide is contained in the composition at a concentration with an improved hemostatic ability compared to direct application.

The present invention relates to a liquid, positively charged, responsive self- assembling peptide, a liquid scaffold material formed from the self-assembling peptide, and applications of the liquid scaffold material.

The application discloses a kind of peptide micropipe / In2O3 / Au composite gas-sensitive materials, its preparation method and application, belong to gas-sensitive material technical field.The material is self-assembled peptide micropipe (SPMFs) as three-dimensional support skeleton, by solution mixing and functional modification, make In2O3 nanoparticle uniform dispersion, Au nanoparticle surface load, form ternary composite system.SPMFs porous structure provides stable load platform for nanoparticle and accelerates gas diffusion, the LSPR effect of Au nanoparticle can enhance visible light absorption and surface reactivity, the heterojunction formed by In2O3 and SPMFs regulates electron transport.Under the synergistic effect of the three, material can detect ethanol at room temperature under visible light excitation, with high selectivity, high sensitivity and fast adsorption and desorption characteristics, detection lower limit is as low as 1 ppm, meet the demand of trace ethanol real-time monitoring.

There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and / or a cation.

The scheme discloses the field of biomedical materials and bone tissue engineering technology, and discloses a composite drug-loaded hydrogel and a preparation method and application thereof.The composite drug-loaded hydrogel comprises a self-assembled peptide hydrogel base, hollow mesoporous dopamine nanoparticles and simvastatin, the simvastatin is loaded in the hollow mesoporous structure of the hollow mesoporous dopamine nanoparticles to form SIM@H-MPDA drug-loaded nanoparticles, and the drug-loaded nanoparticles are stably dispersed in the three-dimensional network structure of RADA16-I.The preparation method of the composite drug-loaded hydrogel is also disclosed, and the preparation method comprises H-MPDA preparation, SIM@H-MPDA drug-loaded nanoparticle preparation and composite hydrogel assembly.The composite drug-loaded hydrogel has good injectability and in-situ gelation, can realize smooth and slow release of simvastatin, significantly promotes osteogenic differentiation and new bone formation, effectively repairs non-infectious bone defects, and has no adverse effects on main organs of the body.

The application discloses an enzyme-triggered self-assembly peptide hydrogel, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The hydrogel comprises a peptide precursor Nap-YY(p)Y, an antibacterial compound daphnodorin and alkaline phosphatase; the peptide precursor is dephosphorylated under the action of the alkaline phosphatase, self-assembled to form a nanofiber network structure, and encapsulates the daphnodorin in the network structure. The hydrogel has a short gelation time (3-10 minutes), a moderate mechanical strength (a storage modulus G' of 130-170 Pa), a high encapsulation rate (greater than or equal to 75%), presents a biphasic release characteristic in a simulated wound liquid, and can maintain an effective therapeutic concentration for more than 7 days. The hydrogel has a significant synergistic killing effect on methicillin-resistant Staphylococcus aureus and a biofilm thereof, can effectively reduce a bacterial load of a wound and accelerate wound healing.

The present application relates to a kind of detection method of self-assembled peptide hydrogel hexadecapeptide content, belong to biological material detection technical field.The method includes the following steps: first instrument preparation, using high performance liquid chromatography (HPLC) as detection equipment;Secondly, preparation of test solution, about 0.2 g self-assembled peptide hydrogel test sample is placed in centrifugal tube, after being dissolved with 2 mL primary water, drying is carried out in vacuum freeze-drying box;The dry powder obtained is added to 0.2 mL formic acid, extracts 30 min under the condition of 37.0 ℃, then add primary water to constant volume to 10 mL, and vortex mixing, obtain test solution;Finally, the test solution is detected by HPLC and the content of hexadecapeptide is calculated.The method is simple in operation, good in repeatability, accurate in detection result, can effectively realize the quantitative detection of self-assembled peptide hydrogel hexadecapeptide content, and has good application value.