Pharmaceutical composition as well as preparation method and application of pharmaceutical composition

A technology of composition and pharmaceutical preparation, applied in the field of pharmaceutical composition, can solve the problems of Fasudil hydrochloride and nucleotide derivatives, etc., and achieve the goal of improving microcirculation, improving vasospasm, and enhancing anti-hypoxia ability Effect

Inactive Publication Date: 2014-11-12
HAINAN HERUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] There is no pharmaceutical composition of fasudil hydrochloride and nucleotide derivatives in the prior art, in view of this, the present invention is proposed

Method used

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  • Pharmaceutical composition as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, the injection containing fasudil hydrochloride and nucleotide derivatives

[0042] prescription:

[0043]

[0044] Preparation:

[0045] After dissolving the prescribed amount of fasudil hydrochloride, adenosine triphosphate disodium and sodium chloride in a small amount of water for injection, add 80% of the full amount of water for injection, stir, mix well, and then add water for injection to the full amount to obtain a total mixed solution; then use Appropriate amount of 0.1mol / L NaOH solution or 0.1mol / L hydrochloric acid solution to adjust the pH value of the resulting mixed solution to 5.8-6.2, add 0.02% (w / v) of activated carbon to the total preparation volume, and then fully circulate and stir for 20 minutes , turn on the sanitary pump, decarburize through a titanium rod filter (or neutral filter paper), circulate in the buffer tank for 5 minutes, return the sample to check the pH value and content, and start the sanitary pump to pass the liqu...

Embodiment 2

[0046] Embodiment 2, the injection containing fasudil hydrochloride and nucleotide derivatives

[0047] prescription:

[0048]

[0049] Preparation method: with embodiment 1.

Embodiment 3

[0050] Embodiment 3, the injection containing fasudil hydrochloride and nucleotide derivatives

[0051] prescription:

[0052]

[0053] Preparation method: with embodiment 1.

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PUM

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a pharmaceutical composition. The pharmaceutical composition contains fasudil hydrochloride and nucleotide derivatives, wherein the content of the nucleotide derivatives in the pharmaceutical composition is 0.1-25 times of the content of the fasudil hydrochloride. The invention also discloses a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the effects of improving the activity of myosin light chain phosphatase to expand blood vessels, reducing the tensions of endothelial cells, improving microcirculation of brain tissues, protecting nerve to avoid apoptosis and promoting nerve regeneration so as to prevent and reduce cerebral vasospasm caused by various reasons and selectively expand the spasmodic blood vessels; and the pharmaceutical composition can also be used for inhibiting the damage of cerebral neurons, promoting the axon growth of neural cells and relieving the inflammatory response of involved brain cells.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, its preparation method and application, in particular, to a pharmaceutical composition composed of fasudil hydrochloride and nucleotide derivatives, its preparation method and its application in improving and preventing arachnoid Cerebral vasospasm after inferior cavity hemorrhage and the cerebral ischemia symptoms caused by it are used to treat the sequelae of cerebral hemorrhage. Background technique [0002] Subarachnoid hemorrhage (SAH) is a type of hemorrhagic cerebrovascular disease, which can be divided into primary and secondary. Primary subarachnoid hemorrhage is caused by rupture and bleeding of blood vessels on the surface and base of the brain, and blood flows directly into the subarachnoid space. Also known as spontaneous SAH. Cerebral parenchymal or ventricular hemorrhage, traumatic subdural or epidural hemorrhage into the subarachnoid space are secondary SAH. The most comm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P9/00A61P9/10A61K31/551
Inventor 钟正明潘正斐
Owner HAINAN HERUI PHARMA
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