10 results about "Peripheral nerve injury" patented technology

The application discloses application of an inhibitor targeting NLRP3 gene in promoting axon regeneration after sciatic nerve injury. It is found for the first time that NLRP3 expression in DRG is significantly up-regulated after sciatic nerve injury. Further, by interfering with the expression of NLRP3 through siRNA targeting NLRP3, the protein level of NLRP3 can be significantly inhibited, and the increase of the number of DRG neuron axons, the total length of axons and the longest axon length can be obviously promoted. The in-vitro and in-vivo experimental results show that NLRP3 is a negative regulation factor of axon regeneration after sciatic nerve injury, and targeted inhibition of NLRP3 expression can effectively promote axon regeneration. Based on this, the application provides an siRNA sequence targeting NLRP3 and application of the siRNA sequence in preparation of a drug for promoting axon regeneration after sciatic nerve injury. The application provides a new molecular target and intervention strategy for peripheral nerve injury repair, and has important theoretical research value and clinical application prospect.

The invention relates to compounds, compositions, and methods for derepressing RE1 silencing transcription factor (REST) target genes are provided. In particular, a peptide having the sequence TEDLEPPEPPLPKEN (SEQ. ID NO: 1) and EDLEPPEPPLPK (SEQ. ID NO: 15), or the reversed sequences made of D-amino acids (retro inverted, RI) nekplppeppeldet (SEQ ID NO: 16) and kplppeppelde (SEQ ID NO: 17), are disclosed for inhibiting REST activity. The peptides are useful to treat, prevent, or ameliorate conditions such as traumatic brain injury, epilepsy, dementia, Huntington's Disease (HD), chronic pain, brain cancer (including glioblastoma multiforme), pancreatic cancer; diabetes, and peripheral nerve injury

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

This invention discloses a non-invasive targeted electrical stimulation device for peripheral nerve injury based on coherent electrical signals, comprising: a flexible electrode array module, an impedance monitoring and sensing module, a flexible fixation adapter module, a coherent electrical signal generation module, a main control chip processing module, and a human-computer interaction control module. Each module is wirelessly connected via medical-grade flexible wires or Bluetooth, forming a wearable stimulation unit and a control and analysis unit. The flexible fixation adapter module adapts to different limbs, the coherent electrical signal generation module generates multiple synchronous carrier signals, and the main control chip processing module realizes functions such as targeted positioning and impedance feedback. This device locks the nerve target site using external imaging data, utilizes the superposition of coherent electrical signals to form a targeted difference frequency signal, and combines impedance monitoring data with dynamic adjustment signals based on multi-dimensional environmental and device-related parameters to achieve non-invasive, precise, and stable targeted electrical stimulation of peripheral nerve injury, improving stimulation specificity and safety.

This invention provides a method for preparing plant nanovesicles derived from pepper. The method involves: crushing washed pepper fruits, enzymatically hydrolyzing them, and then sequentially filtering the crude extract of pepper nanovesicles obtained from the enzymatic hydrolysis through a coarse filter, a microfiltration membrane, and a microporous membrane to obtain a filtrate. The filtrate is then centrifuged to obtain the plant nanovesicles derived from pepper. This invention also provides an application of the prepared plant nanovesicles derived from pepper for the preparation of drugs to improve peripheral nerve injury. The plant nanovesicles derived from pepper of this invention possess anti-inflammatory, analgesic, and nerve-repairing activities, easily penetrate tissue barriers, and promote the absorption and targeted delivery of active ingredients.

This invention discloses a magnetron piezoelectric composite hydrogel and a method for preparing the composite hydrogel, comprising: modifying barium titanate with tannic acid to prepare tannic acid-functionalized barium titanate nanoparticles; modifying superparamagnetic Fe3O4 nanoparticles with carboxyl-terminated polyethylene glycol to obtain carboxylated superparamagnetic nanoparticles; uniformly dispersing the tannic acid-functionalized barium titanate nanoparticles and carboxylated superparamagnetic nanoparticles in deionized water to form a suspension, and then adding polyvinyl alcohol and glycerol to react and obtain the magnetron piezoelectric composite hydrogel. This invention also discloses the application of the above hydrogel in promoting the repair of peripheral nerve injuries. The composite hydrogel of this invention can remotely, non-invasively, and precisely convert mechanical stress into electrical signals that promote nerve regeneration, and can also exert anti-inflammatory and antioxidant stress-regulating microenvironment functions, providing a powerful intelligent platform for the functional regeneration of peripheral nerves.

This invention relates to the field of electromyography (EMG) signal technology, specifically to a method for analyzing and evaluating EMG signals in peripheral nerve injury. The method includes the following steps: acquiring raw EMG signals and environmental noise reference signals. This invention discretizes the intrinsic mode function (IMF) components and the environmental noise reference signal, calculates the length of the discrete signal; calculates the cross-correlation coefficient based on the length, sorts the components to obtain the correlation coefficient of the largest component and determines a threshold, filters effective IMF components according to the threshold, and then integrates them into a set of effective components; processes the IMF components within the set to obtain denoised components, and superimposes the denoised components to obtain a pure EMG signal, effectively removing power frequency interference and patient jitter artifacts, avoiding the accidental deletion of weak EMG signals from early, minor nerve injuries by traditional fixed thresholds, improving the purity of EMG signals with low signal-to-noise ratios, and preserving effective component characteristics even at low signal-to-noise ratios, thus improving the integrity of preserved effective features.

The application discloses application of a compound INF195 in treatment of diseases related to nerve axon injury. 17 H 22 ClNO3.The application proves through research that the compound INF195 can significantly promote axon regeneration of DRG neurons at a concentration of 5 muM, and has no significant effect on neuron activity at the concentration.Further based on an axon injury model of Xona microfluidic chip, it is proved that the INF195 can promote regeneration and extension of axons after injury.Therefore, the compound INF195 can inhibit NLRP3 inflammasome activity, and is an important compound molecule for promoting axon regeneration and repair after nerve injury, and has a good application prospect in preparation of drugs for treating diseases related to nerve axon injury, including peripheral nerve injury and central nerve injury.

The application discloses a preparation method of a functional bacterial cellulose-based nerve conduit with anti-inflammatory and nerve repair promoting functions, and belongs to the field of microbial medical materials and tissue engineering. The application adds polyvinyl alcohol into a characteristic culture medium, co-cultures with Acetobacter xylinum, and adds curcumin in the culture system, to obtain a bacterial cellulose film containing polyvinyl alcohol and curcumin through in-situ synthesis, and then the bacterial cellulose film is purified, freeze-dried, flattened, curled, sutured and shaped to prepare the nerve conduit with a hollow tubular structure. The application utilizes the tackifying and hydrogen bond anchoring effects of polyvinyl alcohol to realize efficient and stable loading of curcumin in the three-dimensional network of bacterial cellulose. The infrared spectrum, X-ray diffraction, animal implantation experiment and cell experiment verify that the nerve conduit has good biocompatibility, significant anti-inflammatory performance and nerve repair promoting function. The method is simple and green, and the prepared nerve conduit has wide application prospects in the field of peripheral nerve injury repair.