81 results about "Peripheral nerve injury" patented technology

The invention relates to the technical field of artificial intelligence assisted medical rehabilitation, in particular to a peripheral nerve injury personalized rehabilitation system and method based on a multi-modal large model, and the method comprises the steps: a feature fusion module employs space-time attention to fuse multi-modal time series data, and constructs an evaluation map; the personalized generation module is combined with historical data and reinforcement learning to generate a scheme containing virtual scene parameters; the interaction feedback module collects data through mixed reality and calculates action deviation; and the adaptive adjustment module adopts a meta-learning optimization model and a distributed iterative output scheme. According to the method, the cross-modal association precision of the motion features and the mechanical parameters is improved, dynamic matching of the training scene and the motion ability of the user is achieved, the virtual environment and the mechanical feedback threshold are optimized by dynamically adjusting the rehabilitation scheme parameters, the scheme optimization period is shortened based on an online iterative optimization mechanism, and the training efficiency is improved. The core defects of personalized adaptation lagging and low utilization efficiency of multi-modal data are overcome.

The invention relates to the technical field of plant extracts, and provides a plant extract composition with synergistic hypoglycemic activity and application thereof, and the plant extract composition comprises a mulberry leaf extract, a white kidney bean extract and bitter gourd powder in a mass ratio of 8: (1-24): (1-64). By optimizing the mass ratio of the mulberry leaf extract, the white kidney bean extract and the bitter gourd powder, the blood sugar reducing effect of the plant extract taking the mulberry leaf extract, the white kidney bean extract and the bitter gourd powder as main raw materials is remarkably superior to that of a plant extract in the prior art. Meanwhile, the plant extract composition also has the effects of synergistically reducing the number of neutrophils around nerves, improving peripheral neuroinflammation, synergistically enhancing the fluorescence intensity of the peripheral nerves, improving peripheral nerve injury and inhibiting the enzymatic activity of a bacterium source dipeptidyl peptidase-4.

The invention relates to a nerve repair guide catheter, a preparation method and application, an electrostatic spinning technology is adopted to construct a nanofiber membrane which is directionally and orderly arranged so as to guide nerve axons to directionally grow, and cell energy metabolism is promoted and tissue repair and regeneration are accelerated through metabolism and conversion of degradation products. Therefore, the nerve injury repairing effect better than that of traditional matrix materials without biological activity, such as PCL, is achieved. According to the invention, a novel solution is provided for solving the problem of insufficient biological activity of a traditional nerve conduit material by constructing a degradable high polymer material with biological activity. Therefore, the regeneration efficiency of peripheral nerve injury repair is improved, and the application prospect of the bioactive material in the fields of tissue engineering and regenerative medicine is expanded.

The application belongs to the field of medical biological materials, and relates to a preparation method of a hierarchical nanofiber composite film for nerve repair and application thereof. The method comprises the following steps: preparing multilayer nanofibers with different internal stresses through continuous multiple electrostatic spinning units, stacking the multilayer nanofibers with different internal stresses to form a composite nanofiber film with an internal stress gradient; chemically crosslinking the composite nanofiber film; performing adhesion molecule adhesion treatment on the upper surface of the composite nanofiber film; and preparing the hierarchical nanofiber composite film with an internal stress gradient and capable of self-deforming under the action of liquid to wrap nerves. The film provided by the application has excellent flexibility, biocompatibility and degradation performance, can efficiently and quickly adhere to the surface of damaged nerves, provides a good support microenvironment for nerve cell growth, promotes nerve regeneration and repair, and has a wide application prospect in the field of peripheral nerve injury repair.

The present invention relates to compounds, compositions and methods for deinhibiting a RE1 silencing transcription factor (REST) target gene. In particular, disclosed is a peptide having the sequences TEDLEPPEPPLPKEN (SEQ ID NO: 1) and EDLEPPEPPLPK (SEQ ID NO: 15) or a reverse sequence (reverse inversion, RI) consisting of D-amino acids nekplppeppeldet (SEQ ID NO: 16) and kplppeppelde (SEQ ID NO: 17), for use in the inhibition of REST activity. The peptides can be used for treating, preventing or alleviating diseases such as traumatic brain injury, epilepsy, dementia, Huntington's disease (HD), chronic pain, brain cancer (including glioblastoma multiforme), pancreatic cancer, diabetes and peripheral nerve injury.

The invention discloses siRNA capable of knocking down Pr18a9 gene expression and application of the siRNA, and relates to the technical field of biological medicine. The invention provides a positive-sense strand sequence and an antisense strand sequence of the siRNA, and the siRNA is used for preparing a preparation for promoting Schwann cell survival. According to the invention, the Prl8a9 gene of SCs is knocked down by virtue of a small interfering RNA technology; by improving the proliferation and migration capabilities of the Schwann cells, the apoptosis rate of the Schwann cells is reduced, and the survival rate of the Schwann cells is further improved. Meanwhile, a transcriptome sequencing technology is applied, key genes and pathways of Schwann cells treated by siPr18a9 are deeply excavated, and a theoretical support is provided for research on a repair mechanism after peripheral nerve injury.

The invention belongs to the technical field of injection auxiliary fixing devices, and particularly relates to a peripheral nerve injury drug delivery auxiliary injection device which comprises a fixing seat, the fixing seat comprises a clamping plate, an adjusting belt is arranged on the clamping plate, an injection position is formed in one side of the clamping plate, and the clamping plate is connected with a bearing table through a connecting plate; a palm groove and a thumb groove are formed in the bearing table, a bearing groove is formed in the top of the bearing table, an adjusting table is installed in the bearing groove, a bearing frame is installed in the adjusting table, an assembly fixing groove is formed in the bearing frame, and a screw joint ring is installed in the assembly fixing groove. The invention aims to provide the auxiliary injection device for peripheral nerve injury drug delivery, the problems that existing manual injection is inaccurate in positioning, poor in stability and inconvenient to operate are solved, accurate alignment of injection positions, stable fixation of limbs of a patient and flexible adjustment of injection angles and heights are achieved, the operation intensity of medical staff is reduced, and the operation efficiency is improved. The drug delivery effect is improved.

The present invention relates to a composition for preventing, ameliorating, or treating neuropathic pain, comprising syringaresinol or a pharmaceutically acceptable salt thereof as an active ingredient. The composition of the present invention may be administered to a subject for which administration of an anticancer agent is scheduled or to which an anticancer agent has been administered, or to a subject which has suffered peripheral nerve damage, to thereby prevent, ameliorate, or treat neuropathic pain.

The present invention discloses a walnut oligopeptide powder with the functions of promoting peripheral nerve regeneration and repairing peripheral nerve injuries and a preparation method thereof, belonging to the technical field of walnut oligopeptide production. The walnut oligopeptide powder uses walnut cake as a raw material, is enzymatically hydrolyzed by an enzyme preparation, and is prepared by fermentation with Kluyveromyces marxianus and Lactobacillus helveticus. The enzyme preparation is trypsin and ficin. Compared with the prior art, the yield of the walnut oligopeptide powder of the present invention is higher. Moreover, it has been proven by experiments that the walnut oligopeptide powder prepared by the present invention can effectively extend the length of peripheral motor nerves and has a good effect on nerve repair.

The application discloses application of an inhibitor targeting NLRP3 gene in promoting axon regeneration after sciatic nerve injury. It is found for the first time that NLRP3 expression in DRG is significantly up-regulated after sciatic nerve injury. Further, by interfering with the expression of NLRP3 through siRNA targeting NLRP3, the protein level of NLRP3 can be significantly inhibited, and the increase of the number of DRG neuron axons, the total length of axons and the longest axon length can be obviously promoted. The in-vitro and in-vivo experimental results show that NLRP3 is a negative regulation factor of axon regeneration after sciatic nerve injury, and targeted inhibition of NLRP3 expression can effectively promote axon regeneration. Based on this, the application provides an siRNA sequence targeting NLRP3 and application of the siRNA sequence in preparation of a drug for promoting axon regeneration after sciatic nerve injury. The application provides a new molecular target and intervention strategy for peripheral nerve injury repair, and has important theoretical research value and clinical application prospect.

The application discloses application of NSUN3 in promoting peripheral nerve injury repair. The application adopts intermittent hypoxia induction to promote peripheral nerve injury repair, and for the first time finds that intermittent hypoxia promotes peripheral nerve injury repair by inducing protein expression of a key protein NSUN3. The application discloses that NSUN3 can be used as a brand-new treatment target, and provides a new research angle and theoretical basis for expanding clinical treatment of peripheral nerve injury.

The invention relates to compounds, compositions, and methods for derepressing RE1 silencing transcription factor (REST) target genes are provided. In particular, a peptide having the sequence TEDLEPPEPPLPKEN (SEQ. ID NO: 1) and EDLEPPEPPLPK (SEQ. ID NO: 15), or the reversed sequences made of D-amino acids (retro inverted, RI) nekplppeppeldet (SEQ ID NO: 16) and kplppeppelde (SEQ ID NO: 17), are disclosed for inhibiting REST activity. The peptides are useful to treat, prevent, or ameliorate conditions such as traumatic brain injury, epilepsy, dementia, Huntington's Disease (HD), chronic pain, brain cancer (including glioblastoma multiforme), pancreatic cancer; diabetes, and peripheral nerve injury

The utility model provides a fixing device for venipuncture, which relates to the technical field of medical instruments and comprises a U-shaped device plate, a fixing plate mounted on the inner side of the U-shaped device plate, memory foam mounted on the fixing plate, a lower fixing cylinder mounted on the inner side of the U-shaped device plate, and an upper fixing cylinder mounted on the lower surface of the fixing plate. The lower fixing cylinder and the upper fixing cylinder are connected through a spring, plug connectors are installed at the two ends of the inner side of the U-shaped device plate, plug connectors are formed in the plug connectors, and a movable plate is installed on the lower portion of the fixing plate. When the soft memory pillow surface is used by a patient with skin laxity, the skin at the laxity part is tensioned and then fixed on the lower side of an arm, the skin at the puncture part is relatively compact, and blood vessels are not easy to slide and are convenient to puncture. The memory pillow is made of soft and comfortable materials, a patient does not feel uncomfortable when making contact with the skin, and especially for a patient with peripheral nerve injury caused by chemotherapy, due to the fact that the patient cannot make contact with a cold object, the soft surface well solves the problem.

The invention provides a device for preventing peripheral nerve injury caused by chemotherapy. The device is used for at least solving the technical problem of peripheral nerve injury caused by chemotherapy in the prior art. The invention provides a device for preventing peripheral nerve injury caused by chemotherapy, which comprises a first heat exchange area which has a first temperature, can be in direct or indirect contact with skin and covers one or more positions close to an artery position, a palm position and a sole position, and a second heat exchange area which has a second temperature and can be in direct or indirect contact with the skin and covers one or more positions close to the artery position, the palm position and the sole position. The second heat exchange area can make direct or indirect contact with the skin and cover at least one position of the positions not in the first heat exchange area, the heat exchange assembly exchanges heat with the first heat exchange area and the second heat exchange area, the first heat exchange area is kept at the first temperature, and at least part of the second heat exchange area is kept at the second temperature. The first heat exchange area for cooling and the second heat exchange area for heating are arranged according to the blood flow direction of the blood vessel, the blood flow can be reduced, neurotoxicity or complications can be reduced, and the body temperature is kept.

The invention discloses siRNA (small interfering Ribonucleic Acid) targeting BACH1 and application of the siRNA in preparation of chronic pain treatment medicines, belongs to the field of biological medicines, and discloses a compound, a composition and a method for regulating BACH1 gene expression, regulating response of activity and regulating characters, diseases or conditions of a BACH1 gene expression pathway. A behavioral result shows that the group of siRNAs can significantly inhibit mechanical hyperalgesia generated by peripheral nerve injury induction; the siRNA is injected into the trigeminal ganglion of a neuropathic pain model mouse, molecular biology experiments show that the siRNA can remarkably reduce expression of BACH1 in the trigeminal ganglion of the mouse in vivo, a new target and a new method are provided for research and development of chronic pain treatment drugs, non-chemical modification and chemical modification nucleic acid molecules of the targeted BACH1 gene are provided, and the application prospect is wide. The traditional Chinese medicine composition has a good medicine effect on chronic pain, lays a foundation for medicine preparation for treating chronic pain, and has great application and popularization value.

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

The present application relates to the technical field of plant extract, and provides a plant extract composition with synergistic hypoglycemic activity and application thereof, wherein the plant extract composition comprises mulberry leaf extract, white kidney bean extract and balsam pear powder with a mass ratio of 8:(1-24):(1-64). The present application optimizes the mass ratio of the mulberry leaf extract, the white kidney bean extract and the balsam pear powder, so that the plant extract with the mulberry leaf extract, the white kidney bean extract and the balsam pear powder as main raw materials has a significantly better effect on reducing blood sugar than the plant extract in the prior art. Meanwhile, the plant extract composition also has the effects of synergistically reducing the number of peripheral nerve neutrophils, improving peripheral nerve inflammation, synergistically enhancing the fluorescence intensity of peripheral nerves, improving peripheral nerve injury, and inhibiting the enzyme activity of bacteria-derived dipeptidyl peptidase-4.

The application provides application of guanine and isoguanine in preparation of drugs for treating or repairing peripheral nerve injury, and relates to the technical field of biomedicine, and the technical scheme is characterized in that the application provides application of guanine Guanine and / or isoguanine Isoguanine in preparation of drugs for treating or repairing peripheral nerve injury.In the application, it is verified through specific examples that adding guanine and isoguanine in resuspended DRG neurons in vitro can significantly promote the growth of DRG neuron axons, and in the application, guanine and isoguanine can regulate DRG neuron cell axon growth in the process of peripheral nerve injury and regeneration, which helps better understand the important role of Guanine and Isoguanine in the process of nerve injury repair, and meanwhile, the effectiveness of the drugs for repairing or treating peripheral nerve injury is verified; and a new target point is provided for treatment of related nervous system diseases.

The invention discloses hydrogel containing 7-amino acid phosphorylated peptide and application of the hydrogel in neural restoration. The hydrogel comprises acellular matrix hydrogel, 7-amino acid phosphorylated peptide, 7-amino acid phosphorylated peptide, 7-amino acid phosphorylated peptide and 7-amino acid phosphorylated peptide, and a 7-amino acid phosphorylated peptide supported in the acellular matrix hydrogel. The 2, 7-amino acid phosphorylated peptide can play a multi-dimensional regulation role in nerve injury microenvironment remodeling, realizes dynamic targeted regulation of peripheral nerve injury microenvironment, and promotes rapid regeneration and recovery of injured peripheral nerves.

The present invention relates to the technical field of peripheral nerve injury suturing, and specifically discloses a radio-stimulated surgical suture for promoting peripheral nerve healing, and its preparation method and application. The radio-stimulated surgical suture comprises a Mo core layer and a PLGA coating. The preparation method of the radio-stimulated surgical suture is as follows: using metallic Mo to form the core layer, ejecting a PLGA spinning solution through a spinneret, and curing it in a coagulation bath to form a film, and forming a uniformly coated PLGA coating on the Mo core layer by wet spinning technology to obtain a radio-stimulated surgical suture for promoting peripheral nerve healing. The radio-stimulated surgical suture prepared by the present invention obtains energy from an external electromagnetic field through electromagnetic induction and capacitive coupling, and forms a stable electric field locally between the suture and the wound, thereby acting on the damaged tissue. The suture can promote neuronal axon growth, Schwann cell migration, etc., and improve the efficiency of nerve tissue regeneration.

The invention provides hydrogel for repairing peripheral nerve injury as well as a preparation method and application of the hydrogel, and belongs to the field of biomedical engineering materials. The hydrogel disclosed by the invention is good in biocompatibility, has degradability, contains a double-layer cross-linked network structure, has the wetting characteristic of common hydrogel, and also has the advantages of collagen antigenicity, biodegradability, high biocompatibility, cell adaptability, tissue regeneration promotion and the like. The hydrogel can effectively promote regeneration and remyelination of nerve fibers, can promote gastrocnemius muscle recovery and promote motor function recovery, and has a good application prospect.

The application belongs to the field of medicine and health technology, and particularly relates to preparation and application of a novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair, which comprises the following steps: (1) grafting acetylcysteine and dopamine on chitosan to prepare modified chitosan gel with self-crosslinking performance as an adhesive layer; (2) preparing sodium alginate and polyacrylamide covalent / non-covalent double crosslinked gel with high strength and toughness as a substrate layer; and (3) uniformly coating the adhesive layer on the substrate layer, and cutting the adhesive layer into blocks of different sizes according to the requirements of use, so that the novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair is obtained.

The invention discloses a medicine for relieving pain. The medicine contains a compound which is used for acupoint administration and is used for targeted excitation of Piezo1 protein. The invention further discloses application of the Piezo agonist in preparation of the medicine for relieving pain. The invention relates to application of a Piezo agonist in relieving neuropathic pain after peripheral nerve injury, and provides a novel non-central analgesic treatment choice for neuropathic pain through a targeted peripheral mechanism. Micro-injection only needs to be carried out at the acupuncture point, systemic side effects of a traditional analgesic medicine are effectively avoided, the central safety is high, the addiction risk is avoided, compared with 20-30 minutes of needle retaining time generally needed by traditional acupuncture treatment of a single acupuncture point, the time consumed by acupuncture point injection is remarkably shortened, and the clinical efficiency requirement is better met.

This invention discloses a non-invasive targeted electrical stimulation device for peripheral nerve injury based on coherent electrical signals, comprising: a flexible electrode array module, an impedance monitoring and sensing module, a flexible fixation adapter module, a coherent electrical signal generation module, a main control chip processing module, and a human-computer interaction control module. Each module is wirelessly connected via medical-grade flexible wires or Bluetooth, forming a wearable stimulation unit and a control and analysis unit. The flexible fixation adapter module adapts to different limbs, the coherent electrical signal generation module generates multiple synchronous carrier signals, and the main control chip processing module realizes functions such as targeted positioning and impedance feedback. This device locks the nerve target site using external imaging data, utilizes the superposition of coherent electrical signals to form a targeted difference frequency signal, and combines impedance monitoring data with dynamic adjustment signals based on multi-dimensional environmental and device-related parameters to achieve non-invasive, precise, and stable targeted electrical stimulation of peripheral nerve injury, improving stimulation specificity and safety.

The invention provides an application of a nitrogen-containing heterocyclic ring compound in preparation of a medicine for treating peripheral neuropathy. The nitrogen-containing heterocyclic ring compound is SB203580. The peripheral neuropathy refers to diseases or injuries involving a peripheral nervous system, and comprises peripheral nerve trauma, adverse drug reaction and axonal dysfunction caused by one or more pathogenic factors of chemical reagents and diabetes mellitus. Researches show that recovery of a sciatic nerve function index (SFI) after peripheral nerve physical injury (sciatic nerve truncation) of a mouse is remarkably improved, the recovery degree of the signal transduction rate of the injured sciatic nerve is improved, myelin sheath regeneration of the injured sciatic nerve is promoted, and the proportion of abductive myelin sheaths in newly formed myelin sheaths is reduced. The invention provides a new potential medicine for treating the peripheral nerve injury. The structure of the SB203580 is shown in the specification.

The present invention relates to the field of medical tissue wrappers for internal anatomy and uses and methods of using the medical tissue wrappers to treat nerve injury. In particular, the present invention relates to a medical tissue wrap for nervous tissue to support repair of peripheral nerve injury by promoting secure application of the medical tissue wrap. Thus, a medical tissue wrap (10) for a mammalian internal anatomy is proposed wherein the medical tissue wrap (10) is formed by a curled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thus defines a longitudinal through-hole (16) for receiving a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced from the circumferential inner end portion (20) by a discontinuous pitch in the circumferential direction. According to other aspects, a medical tissue wrap includes structural outer surface modifications at opposite longitudinal end portions of a wall thereof.

The invention discloses an application of NSUN3 in promotion of peripheral nerve injury repair. Intermittent hypoxia induction is adopted to promote peripheral nerve injury repair, and it is found for the first time that intermittent hypoxia affects peripheral nerve injury repair by inducing lactylation of key protein NSUN3. The NSUN3 disclosed by the invention can be used as a brand-new treatment target, and a new research angle and a theoretical basis are provided for expanding clinical treatment of peripheral nerve injury.

The invention discloses a lignin electrostatic spinning material for neural restoration and a preparation method of the lignin electrostatic spinning material. Aiming at peripheral nerve injury repair, a biological affinity nerve conduit material taking lignin-based electrostatic spinning as a carrier is constructed; the method comprises the following steps: by taking alkaline lignin as a raw material and PAN as a spinning aid, carrying out electrostatic spinning on a solution in which the content of lignin to PAN is 6: 4 to prepare a lignin-based electrostatic spinning material; the composite material has excellent mechanical and mechanical properties. Compared with a PCL spinning material prepared under the same condition, the lignin electrostatic spinning material prepared by the invention has better mechanical properties and better biological activity, and shows a good nerve repairing effect in an animal nerve defect model, so that the lignin electrostatic spinning material provides a high-quality material with high potential for nerve repairing, and has a wide application prospect. The material disclosed by the invention has a good clinical application prospect.

This invention provides a method for preparing plant nanovesicles derived from pepper. The method involves: crushing washed pepper fruits, enzymatically hydrolyzing them, and then sequentially filtering the crude extract of pepper nanovesicles obtained from the enzymatic hydrolysis through a coarse filter, a microfiltration membrane, and a microporous membrane to obtain a filtrate. The filtrate is then centrifuged to obtain the plant nanovesicles derived from pepper. This invention also provides an application of the prepared plant nanovesicles derived from pepper for the preparation of drugs to improve peripheral nerve injury. The plant nanovesicles derived from pepper of this invention possess anti-inflammatory, analgesic, and nerve-repairing activities, easily penetrate tissue barriers, and promote the absorption and targeted delivery of active ingredients.

The present invention relates to the use of botulinum toxins for the treatment of peripheral neuropathic pain (PNP) by topical administration of botulinum toxins. The administration includes subcutaneously injecting an effective amount of botulinum toxin into a region of the skin of the patient affected by pain according to a specific administration regimen. The peripheral neuropathic pain may be, for example, post-herpes zoster neuralgia, peripheral nerve injury (e.g., due to surgery or trauma), trigeminal neuralgia, painful polyneuropathy (e.g., diabetic neuropathic pain), and painful nerve root disease.